Studies on mosquito density in urban Kano: a study to calculate larval indices in municipal area of Gwale, Kano, Nigeria

The study is carried out to standardize larval indices namely House Index, Container Index and Breteau Index and also to identify the major breeding sources of mosquitoes in the residential environment in and around the Gwale Local government area of  Kano, Nigeria. A cross-sectional study by selecting 50 houses randomly from the 6 wards of Municipality was employed. Every water holding container indoors and outdoors were counted and searched for larval presence and noted on a pretested format. In this study, 300 houses were surveyed in 21 days out of which 94.33% (283 houses) were found to have potential sources for mosquito breeding. All the entomological indices were found to be above the critical level. House Index = 28.67%; Container Index = 12.14%; Breteau Index = 64.00% showing high chances for outbreaks of mosquito borne diseases. The area is prone to mosquito borne disease like malaria and therefore warrants interventions from the competent

Impact of Aisami Solid Waste dumping site, Kano Metropolis, Nigeria on the quality of ground water of the neighbouring environment

Open dumping and uncontrolled landfilling of solid wastes are the most widely practiced waste disposal methods in many cities of the less-developed regions, especially those in sub Saharan Africa. These practices are unsustainable and pose a major threat to the environment and public health. Of particular concern is the leachate produced at the disposal sites, which is concentrated with biological and chemical substances that could contaminate the soil, surface and groundwater sources in the environment. The effects of leachate percolation on the quality of groundwater sources is of great concern especially in sub Saharan Africa, where untreated self-supply groundwater options represent a major source of water supply for many inhabitants. Given this perspective, the physicochemical characteristics of some groundwater samples from wells around a major waste disposal site; Aisami in Kano metropolis, Nigeria, were examined. The samples were collected from the north, east, south and west directions around the disposal site and analysed for parameters that include: pH, turbidity, total dissolved solids, electrical conductivity, total alkalinity, total hardness, Ca+2, Mg+2, Na+, K+, NO3-, SO4(2-), Cl-, Cu+2, Fe+2 ,Mn+2, Pb, Zn, and Cr. Significant concentrations of most parameters were revealed, often above the WHO recommended thresholds. Accordingly, some measures were highlighted towards protecting, preserving and sustaining groundwater quality as a strategic source of water supply in the area and beyond

Assessment of phytoremediation potential of Telfaira occidentalis in the removal of Cu, Cd, and Pb in contaminated soil along River Salanta

A Field study was carried out to examine the phytoremediation potential of some plants metals (Cd, Cu and Pb) in contaminated soils along Sallanta river, Kano. A total of one hundred and eighty (100) samples comprising of 40 (soils), 20 (effluents), and 40 (plant parts) of T. 0ccidentalis were analyzed. 0.50g of the plant tissue and 1.0g of soil sample and 50mL of the effluent sample were digested using triacid digestion method and the levels of the metals were determined by the use of atomic absorption spectrophotometry. The mean levels of the metals in plants and soils from contaminated and control sites were found to be in the sequence of Cu (27.08±3.15)> Cd (24.57±8.25)>Pb (3.00±0.52) and Cu (10.10±2.50)> Cd (2.80±0.05)>Pb (2.00±0.63) respectively. The contamination factor (CF) of all the metals in the plants were found to be in the sequence of Cd (8.35±1.53)> Cu (2.52±1.20)>Pb (1.50±0.21). The results showed that these plants can be used for the phytoextraction of the metals from contaminated soils. The values of bioaccumulation and translocation factors were also found to be more than one in almost all cases. From these results it could be recommended that the three plants investigated would be ideal for phytoremediation in multi-metal contaminated soils

Study of starch degrading bacteria from kitchen waste soil in the production of amylase by using paddy straw

The starch degrading amylolytic enzymes are of crucial importance in biotechnology industries with huge application in food, fermentation, textile and paper production. They are universally distribution in bacteria and fungus. Present study aimed at production of pure form of α-amylase from kitchen waste soil with optimization of raw material such as carbon and nitrogen source of the culture media for it. Objective: To evaluate the kitchen waste soil for production of α-amylase with optimization of carbon and nitrogen source required for culture media. Method: The starch degrading bacteria was isolated from the kitchen waste soil environment and was used for production of α-amylase through submerged. The paddy straw extract was shown the best source of carbon and potassium nitrate as the best source of nitrogen with optimum pH 7.0 and temperature of 30ºC. The fermentor parameters were set with the agitator at speed 200rpm with 100% dissolved O2 at fixed temperature and pH. After completion of the fermentation process, the activity of the enzyme was checked by the DNS method. Results: Enzyme produced and purified by this method, was found to have an enzymatic activity of 0.51 mg/ml after column chromatography by nanodrop spectrophotometer and coincide with standard in SDS-PAGE. Here, we have shown the cheap method of commercial production of economically valuable amylase by utilizing paddy straw

Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)

SummaryBackground Apremilast, an oral phosphodiesterase 4 inhibitor, regulates immune responses associated with psoriasis. Objectives ESTEEM 2 evaluated the efficacy and safety of apremilast 30 mg twice daily for moderate-to-severe plaque psoriasis. Methods This phase III, double-blind, placebo-controlled trial randomized adults to apremilast or placebo (2 : 1). At week 16, placebo patients switched to apremilast. At week 32, apremilast patients achieving ≥ 50% reduction in Psoriasis Area and Severity Index (PASI 50) were rerandomized (1 : 1) to continue apremilast or receive placebo. Upon loss of 50% of PASI improvement obtained at week 32, patients rerandomized to placebo resumed apremilast. Results The modified intention-to-treat population (full analysis set) included 137 placebo and 274 apremilast patients. At week 16, significantly more apremilast patients achieved PASI 75 (28·8%), PASI 50 (55·5%) and static Physician's Global Assessment score of 0 or 1 (20·4%) vs. placebo (5·8%, 19·7%, 4·4%, respectively; P < 0·001). Most patients rerandomized to apremilast at week 32 had a PASI 50 response at week 52 (80%). Patients treated with apremilast showed significant improvements in quality of life (as assessed by the Dermatology Life Quality Index) and pruritus at week 16 compared with placebo (P < 0·001). The exposure-adjusted incidence of adverse events did not increase with continued apremilast treatment for up to 52 weeks. The most common adverse events were nausea, diarrhoea, nasopharyngitis and upper respiratory tract infection. Conclusions Apremilast was effective in the treatment of moderate-to-severe plaque psoriasis over 52 weeks

Instability, Intermixing and Electronic Structure at the Epitaxial LaAlO3/SrTiO3(001) Heterojunction

The question of stability against diffusional mixing at the prototypical LaAlO3/SrTiO3(001) interface is explored using a multi-faceted experimental and theoretical approach. We combine analytical methods with a range of sensitivities to elemental concentrations and spatial separations to investigate interfaces grown using on-axis pulsed laser deposition. We also employ computational modeling based on the density function theory as well as classical force fields to explore the energetic stability of a wide variety of intermixed atomic configurations relative to the idealized, atomically abrupt model. Statistical analysis of the calculated energies for the various configurations is used to elucidate the relative thermodynamic stability of intermixed and abrupt configurations. We find that on both experimental and theoretical fronts, the tendency toward intermixing is very strong. We have also measured and calculated key electronic properties such as the presence of electric fields and the value of the valence band discontinuity at the interface. We find no measurable electric field in either the LaAlO3 or SrTiO3, and that the valence band offset is near zero, partitioning the band discontinuity almost entirely to the conduction band edge. Moreover, we find that it is not possible to account for these electronic properties theoretically without including extensive intermixing in our physical model of the interface. The atomic configurations which give the greatest electrostatic stability are those that eliminate the interface dipole by intermixing, calling into question the conventional explanation for conductivity at this interface - electronic reconstruction. Rather, evidence is presented for La indiffusion and doping of the SrTiO3 below the interface as being the cause of the observed conductivity

Erratum to: Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines Using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry.

A high content molecular fragmentation for the analysis of phosphatidylcholines (PC) was achieved utilizing a two-stage [trap (first generation fragmentation) and transfer (second generation fragmentation)] collision-induced dissociation (CID) in combination with travelling-wave ion mobility spectrometry (TWIMS). The novel aspects of this work reside in the fact that a TWIMS arrangement was used to obtain a high level structural information including location of fatty acyl substituents and double bonds for PCs in plasma, and the presence of alkali metal adduct ions such as [M + Li](+) was not required to obtain double bond positions. Elemental compositions for fragment ions were confirmed by accurate mass measurements. A very specific first generation fragment ion m/z 577 (M-phosphoryl choline) from the PC [16:0/18:1 (9Z)] was produced, which by further CID generated acylium ions containing either the fatty acyl 16:0 (C(15)H(31)CO(+), m/z 239) or 18:1 (9Z) (C(17)H(33)CO(+), m/z 265) substituent. Subsequent water loss from these acylium ions was key in producing hydrocarbon fragment ions mainly from the α-proximal position of the carbonyl group such as the hydrocarbon ion m/z 67 (+H(2)C-HC = CH-CH = CH(2)). Formation of these ions was of important significance for determining double bonds in the fatty acyl chains. In addition to this, and with the aid of (13)C labeled lyso-phosphatidylcholine (LPC) 18:1 (9Z) in the ω-position (methyl) TAP fragmentation produced the ion at m/z 57. And was proven to be derived from the α-proximal (carboxylate) or distant ω-position (methyl) in the LPC. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13361-011-0172-2) contains supplementary material, which is available to authorized users