The modern view on the problem of the surgical treatment of patients with pathology of the pancreas accompanied by obstructive jaundice

Catedra de chirurgie nr.2, Curs de chirurgie pediatrică, Universitatea Națională de Medicină, Odessa, Ucraina, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Rezultatele tratamentului chirurgical la pacienții cu patologie pancreatică pe un fundal de icter mecanic depind nu numai de cauza bolii de bază, dar de asemenea de diagnosticul oportun, durata icterului și volumul tratamentului chirurgical realizat. Scopul studiului a fost îmbunătățirea rezultatelor tratamentului chirurgical al pacienților cu sindrom de icter mecanic prin crearea unei metode de diagnostic diferențiat al patologiei de bază, cu determinarea ulterioară a volumului intervenției chirurgicale. Material și metode: Pe parcursul perioadei 2010-2015 în Clinica noastră au fost supuși tratamentului chirurgical 114 pacienți cu sindrom de icter mecanic. Algoritmul de diagnostic a inclus obigatoriu ultrasonografia, CT, MRI, FEGDS și ERCP. În unele cazuri a fost efectuată analiza genetică pentru prezența unor tipuri de mutații genice specifice. Evident pentru leziunile maligne ale pancreasului cefalic au fost verificați marcherii specifici oncogenici (CEA, CA 19-9). Cancerul de pancreas a fost confirmat la 42 (36,8%) pacienți, diferite forme de pancreatită cronică a fost găsite la 72 (63,2%) pacienți. Rezultate: Decompresia asistată laparoscopic sau cu ghidaj ultrasonografic a arborelui biliar a fost efectuată la 96 (84,2%) pacienți. La 17 pacienți cu pancreatită cronică s-a efectuat intervenție chirurgicală economă – procedeul Beger în volumul Bernese. La pacienții rămași (55) s-a efectuat rezecția pancreatoduodenală (RPD) prin metode proprii. RPD pentru cancer s-a efectuat la 42 pacienți, 7 pacienți au decedat. Rata de mortalitate a constituit 6.1%.The results of surgical treatment of patients with pathology of the pancreas on a background of jaundice is not only due to the nature of the underlying disease, but also its timely diagnosis, length of jaundice and volume of performed surgery. The aim of the study was to improve the results of surgical treatment of patients with obstructive jaundice syndrome by creating a new approach to the differential diagnostics of underlying disease with subsequent determining of the surgical intervention volume. Materials and methods_ From 2010 to 2015 in our clinic the surgical treatment of 114 patients with the obstructive jaundice syndrome was performed. The diagnostic algorithm includes the mandatory implementation of ultrasound, CT, MRI, FEGDS,ERCP. In certain cases, a genetic analysis for the presence of type-specific gene mutations was carried out. Obviously, for malignant lesions of the head of the pancreas verification of specific oncomarkers (CEA, CA 19-9) levels were estimated. Pancreatic cancer was verified in 42 (36.8%) patients, different forms of chronic pancreatitis were found in 72 (63.2%) patients. Results_ Ultrasound-guided or laparoscopy-assisted decompression of the biliary tree was performed in 96 (84.2%) patients. In17 patients with chronic pancreatitis sparing surgery in the volume of Bernese type of Beger’s procedure was done. In the rest patients (55) pancreatico-duodenal resection (PDR) by own methods was performed. PDR for cancer is performed in 42patients, 7 patients died. The mortality rate was 6.1%

Structural, electronic, and magneto-optical properties of YVO3_3

Optical and magneto-optical properties of YVO$_3$ single crystal were studied in FIR, visible, and UV regions. Two structural phase transitions at 75 K and 200 K were observed and established to be of the first and second order, respectively. The lattice has an orthorhombic $Pbnm$ symmetry both above 200 K as well as below 75 K, and is found to be dimerized monoclinic $Pb11$ in between. We identify YVO$_3$ as a Mott-Hubbard insulator with the optical gap of 1.6 eV. The electronic excitations in the visible spectrum are determined by three $d$-bands at 1.8, 2.4, and 3.3 eV, followed by the charge-transfer transitions at about 4 eV. The observed structure is in good agreement with LSDA+$U$ band structure calculations. By using ligand field considerations, we assigned these bands to the transitions to the $^4A_{2g}$, $^2E_{g} + ^2T_{1g}$, and $^2T_{2g}$ states. The strong temperature dependence of these bands is in agreement with the formation of orbital order. Despite the small net magnetic moment of 0.01 $\mu_B$ per vanadium, the Kerr effect of the order of $0.01^\circ$ was observed for all three $d$-bands in the magnetically ordered phase $T_{\text{N\'eel}}<116 K$. A surprisingly strong enhancement of the Kerr effect was found below 75 K, reaching a maximum of $0.1^\circ$. The effect is ascribed to the non-vanishing net orbital magnetic moment.Comment: Submitted to Phys. Rev.

The latest advances in chemistry of 1,2,4-oxadiazines (microreview)

[Figure not available: see fulltext.] [Figure not available: see fulltext.]This microreview covers recently published data (2011–2016) on the methods of synthesis and chemical properties of 1,2,4-oxadiazines and their hydrogenated derivatives.[Figure not available: see fulltext.]. © 2017, Springer Science+Business Media, LLC

The latest advances in chemistry of 1,2,4-oxadiazines (microreview)

[Figure not available: see fulltext.] [Figure not available: see fulltext.]This microreview covers recently published data (2011–2016) on the methods of synthesis and chemical properties of 1,2,4-oxadiazines and their hydrogenated derivatives.[Figure not available: see fulltext.]. © 2017, Springer Science+Business Media, LLC

НОВЫЙ ПОДХОД К СИНТЕЗУ АЗОТ- И КИСЛОРОДСОДЕРЖАЩИХ МАКРОЦИКЛИЧЕСКИХ СОЕДИНЕНИЙ

Alkylation of difuryl-substituted piperidones with 3-benzyl-1,5,3-dioxazepane in the presence of trimethylsilyl chloride leads to the formation of a wide range of new macrocycles.Алкилирование дифурилзамещенных пиперидонов 3-бензил-1,5,3-диоксазепаном в присутствии триметилхлорсилана приводит к получению ряда новых макроциклических соединени

First synthesis of 6-spiro[5-aza-2-oxatricyclo[6.2.1.03,9]Undec-3-ene-6, 1′-cyclohexane] [2]

[No abstract available

Product structure in the reaction of dimethyl acetylenedicarboxylate with 2-furyl-1,2,3,4-tetrahydroquinolines

Dimethyl acetylenedicarboxylate reacts with 4-substituted and 3,4-fused 2-furyl-1,2,3,4-tetrahydroquinoline derivatives at the furan fragment according to the [4 + 2]-cycloaddition pattern. The reaction is not stereoselective, and it yields two diastereoisomeric 7-oxabicyclo[2.2.1]hepta-2,5-dienes whose structure was determined by X-ray analysis and NMR spectroscopy. © 2007 Pleiades Publishing, Ltd