38 research outputs found
ΠΠ°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·ΠΎΠ±Π΅Π΄ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²ΠΎΠ²: ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ Π΄ΠΎΠΊΠ»Π°Π΄ ΠΎ ΠΏΠΈΠ»ΠΎΡΠ½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ΅ ΠΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ ΠΈΠΌ. Π .Π . ΠΡΠ΅Π΄Π΅Π½Π°
Background. Today in our country, the follow-up of patients after arthroplasty is carried out in accordance with clinical guidelines, the wording of which is based on monographs from 2006, 2008, and 2014, in addition, clinical guidelines for follow-up do not take into account the results of treatment assessed by the patient himself.
The purpose of this study was to examine existing systems and develop a proprietary follow-up system for patients after hip and knee arthroplasty.
Results. A review of the literature revealed that follow-up of patients after arthroplasty is an unsolved problem, within which there is low coverage, reluctance or forgetfulness of the asymptomatic patient, the problem of accessibility of medical examinations, and an excessive financial burden on the health care system. Since 2022, fixed recommendations for follow-up after arthroplasty have been used in the clinical practice of our center in discharge epicrisis. Recommendations for the frequency of follow-up were formulated by experts based on a comprehensive review of the literature and their own experience. In the first three months, 221 hip and 235 knee evaluation questionnaires were collected through the proposed mechanism, with a progressive increase in the number of questionnaires based on weekly monitoring data.
Conclusion. Unfortunately, the outpatient clinic system is not always able to provide qualitative monitoring of patients after arthroplasty due to various reasons, therefore, in our opinion, the implementation of the mechanism of remote monitoring of patients will allow detecting various complications at the stage of early diagnosis, which will contribute to prompt solution of these problems. The remote monitoring system is also an important source of scientific data.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠ° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ Π² Π ΠΎΡΡΠΈΠΈ Π΄ΠΈΡΠΏΠ°Π½ΡΠ΅ΡΠ½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΡΡΡ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌΠΈ, ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²ΠΊΠΈ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
ΠΎΡΠ½ΠΎΠ²Π°Π½Ρ Π½Π° ΠΌΠΎΠ½ΠΎΠ³ΡΠ°ΡΠΈΡΡ
2006, 2008 ΠΈ 2014 Π³Π³. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π΄ΠΈΡΠΏΠ°Π½ΡΠ΅ΡΠ½ΠΎΠΌΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π½Π΅ ΡΡΠΈΡΡΠ²Π°ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΠΎΡΠ΅Π½Π΅Π½Π½ΡΠ΅ ΡΠ°ΠΌΠΈΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΌ.
Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·ΠΎΠ±Π΅Π΄ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²ΠΎΠ².
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ Π²ΡΡΠ²ΠΈΠ», ΡΡΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠΌΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ ΡΠ²Π»ΡΡΡΡΡ Π½ΠΈΠ·ΠΊΠΈΠΉ ΠΎΡ
Π²Π°Ρ, Π½Π΅ΠΆΠ΅Π»Π°Π½ΠΈΠ΅ ΠΈΠ»ΠΈ Π·Π°Π±ΡΠ²ΡΠΈΠ²ΠΎΡΡΡ Π°ΡΠΈΠΌΠΏΡΠΎΠΌΠ½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΎΡΠΌΠΎΡΡΠΎΠ², ΠΈΠ·Π±ΡΡΠΎΡΠ½Π°Ρ ΡΠΈΠ½Π°Π½ΡΠΎΠ²Π°Ρ Π½Π°Π³ΡΡΠ·ΠΊΠ° Π½Π° ΡΠΈΡΡΠ΅ΠΌΡ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ. Π‘ 2022 Π³. Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΠΠΠ¦ Π’Π ΠΈΠΌ. Π .Π . ΠΡΠ΅Π΄Π΅Π½Π° Π² Π²ΡΠΏΠΈΡΠ½ΡΡ
ΡΠΏΠΈΠΊΡΠΈΠ·Π°Ρ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ½ΠΎΡΡΠΈ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΉ Π±ΡΠ»ΠΈ ΡΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΊΡΠΏΠ΅ΡΡΠ°ΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π²ΡΠ΅ΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΠΎΠ±Π·ΠΎΡΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ°. ΠΠ° ΠΏΠ΅ΡΠ²ΡΠ΅ ΡΡΠΈ ΠΌΠ΅ΡΡΡΠ° ΡΠΎΠ±ΡΠ°Π½Π° 221 Π°Π½ΠΊΠ΅ΡΠ° ΠΏΠΎ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠ°Π·ΠΎΠ±Π΅Π΄ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° ΠΈ 235 ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π°, ΠΏΡΠΈΡΠ΅ΠΌ ΡΠΈΡΠ»ΠΎ Π°Π½ΠΊΠ΅Ρ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π΅ΠΆΠ΅Π½Π΅Π΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π ΡΠΎΠΆΠ°Π»Π΅Π½ΠΈΡ, ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π½Π΅ Π²ΡΠ΅Π³Π΄Π° ΠΌΠΎΠΆΠ΅Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΡΠΈΠ»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΡΠΈΡΠΈΠ½, ΠΏΠΎΡΡΠΎΠΌΡ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ, Π½Π° Π½Π°Ρ Π²Π·Π³Π»ΡΠ΄, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π²ΡΡΠ²Π»ΡΡΡ Π½Π° ΡΡΠ°ΠΏΠ΅ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ, ΡΡΠΎ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΌΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. Π’Π°ΠΊΠΆΠ΅ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π²Π°ΠΆΠ½ΡΠΉ ΠΈΡΡΠΎΡΠ½ΠΈΠΊ Π½Π°ΡΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΡΡΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·ΠΎΠΌ: ΡΠ°Π·ΡΡΠ² ΠΌΠ΅ΠΆΠ΄Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΠΎΠΉ ΠΈ ΠΌΠ½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠ°ΠΊΡΠΈΠΊΡΡΡΠ΅Π³ΠΎ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠ°
Background. For many decades arthroscopy considered to be the least invasive procedure among all surgical interventions for treatment of knee osteoarthritis (OA). In the beginning of XXI century several randomized clinical studies (RCS) demonstrated inefficiency of lavage and debridement for knee OA. The evidence regarding partial meniscectomy for this category of patients remained uncertain. Therefore the published clinical guidelines are either controversial or inconclusive.
The aim of this study was to critically review the current RCS and meta-analyses of RCS as well as actual clinical guidelines of international orthopedic societies and compare them to expert opinions.
Methods. We searched PubMed and eLIBRARY databases for high evidence research and analyzed the current clinical guidelines dedicated to partial meniscectomy for knee OA. Sixty orthopedic surgeons specialized in this field interviewed anonymously to clarify the decision making process in real clinical practice.
Results. More than patients with knee 2/3 OA of with degenerative meniscal tear benefit from non-surgical treatment therefore indication for arthroscopic partial meniscectomy is limited. The majority of current clinical guidelines consider surgery as an second option if conservative treatment failed and only for non-advanced knee OA. On the contrary experts interview demonstrated the lack of standardized approach as well as a lot of controversies in clinical decision making.
Conclusion. The future research dedicated to partial meniscectomy in knee OA should be appropriately designed to clearly differentiate the sub-population of patient who may benefit from arthroscopy in the long-term without carrying the risk of rapid disease progression with premature conversion to arthroplasty.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΡΡΠΎΡΠΊΠΎΠΏΠΈΡ ΠΌΠ½ΠΎΠ³ΠΈΠ΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ ΡΡΠΈΡΠ°Π»Π°ΡΡ Π½Π°ΠΈΠΌΠ΅Π½Π΅Π΅ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠΌ ΠΈΠ· Π²ΡΠ΅Ρ
ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·ΠΎΠΌ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ Π² Π½Π°ΡΠ°Π»Π΅ XXI Π². ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ (Π ΠΠ) ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Π±Π΅ΡΠΏΠΎΠ»Π΅Π·Π½ΠΎΡΡΡ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π°Π²Π°ΠΆΠ° ΠΈ Π΄Π΅Π±ΡΠΈΠ΄ΠΌΠ΅Π½ΡΠ° Ρ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΠΈ ΠΏΡΠΈ Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·Π΅ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠ°Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½Π°Ρ Π±Π°Π·Π° ΠΎΡΡΠ°Π΅ΡΡΡ Π²Π΅ΡΡΠΌΠ° ΡΠ°Π·Π½ΠΎΡΠΎΠ΄Π½ΠΎΠΉ, ΡΡΠΎ ΠΎΡΡΠ°ΠΆΠ°Π΅ΡΡΡ Π² ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΠΎΡΡΠΈ ΠΈΠ»ΠΈ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ², ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅.
Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·ΠΎΠΌ Π΄Π»Ρ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΌΠ½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠ°ΠΊΡΠΈΠΊΡΡΡΠΈΡ
ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠΎΠ² ΠΏΠΎ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΠΌΠΈ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π ΠΠ ΠΈ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·Ρ Π ΠΠ Π² Π±Π°Π·Π°Ρ
Π΄Π°Π½Π½ΡΡ
eLIBRARY ΠΈ PubMed, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ Π²Π΅Π΄ΡΡΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ², ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·ΠΎΠΌ. ΠΠ»Ρ Π΄Π΅ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΡΠΈΠ½ΡΡΠΈΡ ΡΠ΅ΡΠ΅Π½ΠΈΠΉ Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΈ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΠ»ΠΈ ΠΌΠ½Π΅Π½ΠΈΡ ΡΠΊΡΠΏΠ΅ΡΡΠ° Π² ΠΈΠ΅ΡΠ°ΡΡ
ΠΈΠΈ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ Π±ΡΠ» ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ Π°Π½ΠΎΠ½ΠΈΠΌΠ½ΡΠΉ ΠΎΠΏΡΠΎΡ 60 ΠΏΡΠ°ΠΊΡΠΈΠΊΡΡΡΠΈΡ
ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ²-ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΎΠ², ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·ΠΈΡΡΡΡΠΈΡ
ΡΡ Π½Π° Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π½Π°ΡΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ, ΡΡΠΎ Π±ΠΎΠ»Π΅Π΅ 2/3 Π±ΠΎΠ»ΡΠ½ΡΡ
Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·ΠΎΠΌ Ρ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅Π½ΠΈΡΠΊΠ° Π΄ΠΎΡΡΠΈΠ³Π°ΡΡ ΠΊΡΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΠΏΠΎΡΡΠΎΠΌΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ ΠΊ Π°ΡΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΏΡΠΈ Π΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° Π½ΠΎΡΡΡ Π²Π΅ΡΡΠΌΠ° ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ. ΠΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΡΠΊΠ»ΠΎΠ½ΡΡΡΡΡ ΠΊ Π°ΡΡΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΠΈ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ΅ΡΠΎΠ΄Π° Π²ΡΠ±ΠΎΡΠ° Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ ΠΏΠΎΡΠ»Π΅ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·Π°. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠΉ Π½Π°ΠΌΠΈ ΠΎΠΏΡΠΎΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ Π΅Π΄ΠΈΠ½ΠΎΠ³ΠΎ ΠΌΠ½Π΅Π½ΠΈΡ ΠΎ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΡΡΠ΅Π΄ΠΈ ΠΏΡΠ°ΠΊΡΠΈΠΊΡΡΡΠΈΡ
ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠΎΠ².
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠ½ΠΎΠ²ΡΠ²Π°ΡΡΡ Π½Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
, ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΊΠΎΠ½ΡΡΠ°ΡΠΈΡΠΎΠ²Π°ΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΌΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡ Π²ΡΡΠ²ΠΈΡΡ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠΌ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΎΠΌ Π³ΠΎΠ½Π°ΡΡΡΠΎΠ·Π°, Ρ ΠΊΠΎΡΠΎΡΡΡ
Π°ΡΡΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠ΅Π½ΠΈΡΠΊΡΠΊΡΠΎΠΌΠΈΡ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π² Π΄ΠΎΠ»Π³ΠΎΡΡΠΎΡΠ½ΠΎΠΉ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅, Π½Π΅ ΡΡΠΊΠΎΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡΡ ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
Correlated Interball/ground-based observations of isolated substorm: The pseudobreakup phase
International audienceWe study the isolated substorm that occurred after a long quiet period, which showed all of the substorm signatures except for the first half hour of the expansion phase, which could be characterized as a pseudobreakup sequence, rather than a full-scale substorm onset. During the considered event, the substorm's instability leads to a current disruption, which starts at the near-Earth plasma sheet and then propagates tailward. Based on auroral observations, the analysis of geosynchronous plasma injections, and the plasma sheet observations at ~15 RE at the meridian of auroral substorm development we show that (1) before and probably during "pseudobreakup phase", the plasma sheet stayed cold and dense, (2) during the pseudobreakup phase, particle injections at 6.6 RE were only seen in unusually low energy components, and (3) the electron precipitation into the ionosphere was very soft. We conclude that the basic difference between pseudobreakups and "real" substorm activations was found in the low energy of all manifestations. We suggest that high density and low electron temperature in the plasma sheet are the reasons for low energization in the magnetic reconnection operated on closed field lines in the plasma sheet, as well as the weak field-aligned acceleration, as predicted by the Knight's relationship. The low Hall conductivity could then be the reason for the weak ground magnetic effects observed. This explanation suggests that the role of the ionospheric conductivity is "passive" as the plasma sheet, rather than the ionosphere, controls the development of the magnetospheric instability
Π Π°Π½Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΡ ΠΌΠΎΠ΄ΡΠ»ΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ² Π΄Π»Ρ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°ΡΠΈΠ·Π°ΡΠ½ΠΎ-Π΄ΠΈΠ°ΡΠΈΠ·Π°ΡΠ½ΡΡ ΠΊΠΎΡΡΠ½ΡΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΡΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ΅ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π°
The aim of this study was the assessment of early outcomes of patient-specific three-dimensional titanium cones with specified porosity parameters to compensate for extensive metaphysical-diaphyseal bone defects in RTKA.Materials and Methods. Since 2017 till 2019 30 patient-specific titanium cones (12 femoral and 18 tibial) implanted during 26 RTKAS. Clinical outcomes evaluated using KSS, WOMAC and fjS-12 scoring systems on average 10 (2β18) months after surgery. At the same time the stability of implant fixation analyzed using frontal, lateral and axial knee roentgenograms.Results. During all procedures there were no technical difficulties in positioning and implantation of custom-made titanium cones. At the time of preparation of the publication, none of the patients had indications for further surgical intervention, as well as intra- and postoperative complications. Six months after surgery all scores improved significantly: KSS from 23 (2β42, SD 19.96) to 66.5 (62β78, SD 7.68), WOMAC from 59 (56β96, SD 28.31) to 32.25 (19β46, SD 11.76), the index FJS-12 was 29.16 points (0β68.75, SD 30.19). The average scores continued to improve up to 18 months: KSS β 97.5 (88β108, SD 9.14), WOMAC β 16.5 (9β24, SD 6.45), FJS-12 β 45.85 (25β75, SD 22.03). No radiolucent lines were noticed during this period of observation.Conclusion. The original additive technology of designing and producing patient-specific titanium cones for compensation of extensive metaphyseal-diaphyseal bone defects in RTKA is a valid solution at least in the short term. A longer follow-up period is required to assess its medium-and long-term reliability compared to existing alternative surgical solutions.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»Π°ΡΡ ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ°Π½Π½ΠΈΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅ΠΉ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡ ΠΈ ΡΠΎΠ·Π΄Π°Π²Π°ΡΡ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ΅Ρ
ΠΌΠ΅ΡΠ½ΡΠ΅ ΡΠΈΡΠ°Π½ΠΎΠ²ΡΠ΅ ΠΊΠΎΠ½ΡΡΡ Ρ Π·Π°Π΄Π°Π½Π½ΡΠΌΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ ΠΏΠΎΡΠΈΡΡΠΎΡΡΠΈ ΠΈ Π°Π΄Π³Π΅Π·ΠΈΠΈ Π΄Π»Ρ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΠΈΠ·Π°ΡΠ½ΠΎ-Π΄ΠΈΠ°ΡΠΈΠ·Π°ΡΠ½ΡΡ
ΠΊΠΎΡΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΡΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ΅ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π‘ 2017 ΠΏΠΎ 2019 Π³. Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΏΡΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΡΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ΅ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° 30 ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ (12 Π±Π΅Π΄ΡΠ΅Π½Π½ΡΡ
ΠΈ 18 Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²ΡΡ
) 26 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ°Π½Π½ΠΈΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΡΡΠΊΠΎΡΠ·ΡΡΠ½ΡΡ
Π²Π΅ΡΡΠΈΠΉ Π±Π°Π»Π»ΡΠ½ΡΡ
ΡΠΊΠ°Π» ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° KSS, WOMAC, FJS-12 Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠ΅ΡΠ΅Π· 10 (2β18) ΠΌΠ΅ΡΡΡΠ΅Π² ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ. Π Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ ΡΡΠΎΠΊΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π°Π½Π°Π»ΠΈΠ· ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·Π° ΠΏΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ³ΡΠ°ΠΌΠΌΠ°ΠΌ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° Π² ΡΡΠ΅Ρ
ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΡ
.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎ Π²ΡΠ΅Ρ
Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡΡ
Π½Π΅ Π±ΡΠ»ΠΎ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ Π² ΠΏΠΎΠ·ΠΈΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΈ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΡ
ΡΠΈΡΠ°Π½ΠΎΠ²ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ². Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ Π½ΠΈ Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ ΠΊ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠΌΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Ρ, ΡΠ°Π²Π½ΠΎ ΠΊΠ°ΠΊ ΠΈ Π½Π΅ Π±ΡΠ»ΠΎ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΈΠ½ΡΡΠ°- ΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. Π Π°Π½Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΠΈΡΡ
ΠΎΠ΄Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΎΡΠ΅Π½Π΅Π½Ρ Ρ Π²ΡΠ΅Ρ
26 ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠ΅ΡΠ΅Π· 6 ΠΈ 18 ΠΌΠ΅ΡΡΡΠ΅Π² ΠΏΠΎΡΠ»Π΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°. Π§Π΅ΡΠ΅Π· ΠΏΠΎΠ»Π³ΠΎΠ΄Π° Π±Π°Π»Π»ΡΠ½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΠ½ΠΊΡΠΈΠΈ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ»ΡΡΡΠΈΠ»Π°ΡΡ: KSS Ρ 23 (2β42; SD 19,96) Π΄ΠΎ 66,5 (62β78; SD 7,68), WOMAC c 59 (56β96; SD 28,31) Π΄ΠΎ 32,25 (19β46; SD 11,76), ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ FJS-12 ΡΠΎΡΡΠ°Π²ΠΈΠ» 29,16 Π±Π°Π»Π»Π° (0β68,75; SD 30,19). Π§Π΅ΡΠ΅Π· 18 ΠΌΠ΅ΡΡΡΠ΅Π² ΡΡΠ΅Π΄Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π±Π°Π»Π»ΡΠ½ΡΡ
ΡΠΊΠ°Π» ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ: KSS β 97,5 (88β108; SD 9,14), WOMACβ 16,5 (9β24; SD 6,45), FJS-12 β 45,85 (25β75; SD 22,03). Π Π΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠ½Π΄ΠΎΠΏΡΠΎΡΠ΅Π·Π° Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½Π°Ρ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½Π°Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ
ΡΠΈΡΠ°Π½ΠΎΠ²ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ² Π΄Π»Ρ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΠΈΠ·Π°ΡΠ½ΠΎ-Π΄ΠΈΠ°ΡΠΈΠ·Π°ΡΠ½ΡΡ
ΠΊΠΎΡΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΠΈ ΡΠ΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΡΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ΅ ΠΊΠΎΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΡΠ°Π²Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡΠΌ Π² Π±Π»ΠΈΠΆΠ°ΠΉΡΠ΅ΠΉ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π΅Π΅ ΡΡΠ΅Π΄Π½Π΅ΡΡΠΎΡΠ½ΠΎΠΉ ΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠΉ Π½Π°Π΄Π΅ΠΆΠ½ΠΎΡΡΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΠΌΠΈ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΡΠΌΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡΠΌΠΈ, Π½Π΅ΡΠΎΠΌΠ½Π΅Π½Π½ΠΎ, ΡΡΠ΅Π±ΡΠ΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ
The morphological changes of the aeroheamatic barrier of the respiratory portion of lungs at chronic hepatic insufficiency.
The purpose of the work was to determine the consequence of pathomorphological changes of the respiratory part and surfactant system of lungs at hepatic insufficiency, and also to estimate the dynamics of changes of both compensate and decompensate types in experimental model. 88 mature rats both sexes for modeling of the hepatic insufficiency by the Π‘Π°mΠ΅Π³ΠΎnβs method were used. Rat lungs were examined in 2, 4, 8 and 16 weeks after beginning of experiment. The increase of the volume of regions with emphysema, dysthelectasis and athelectasis at in the respiratory portion of the lungs were found. The increase of interstitial components with decreasing of relative thickness of epithelial layer of alveoli and the endothelial cells in capillaries were observed in aero-hematic barrier. The increase of vessel permeability, formation of hemorrhages, dysthelectasis and athelectasis are observed in the respiratory portion at chronic hepatic insufficiency. The sclerotic changes in the interalveolar septa with pneumofibrosis are determined in the terminal stages of chronic endotoxicosis
Sharp difference in the rate of formation and stability of the DielsβAlder reaction adducts with 2,3-dicyano-1,4-benzoquinone and N-phenylimide-1,4-benzoquinone-2,3-dicarboxylic acid
This work reports new studies of the activity and DielsβAlder kinetics of a series of dienophiles: tetracyanoethylene (1), 2,3-dicyano-p-benzoquinone (10), and N-phenylimide-1,4-benzoquinone-2,3-dicarboxylic acid (11). Rate differences are interpreted in terms of the donorβacceptor properties of the reagents. The relative Ο-acceptor properties of the dienophiles are probed by measuring their interaction energies with a series Ο-donor solvents: benzene, toluene, o-xylene, and chlorobenzene. The normalized interaction energies of 1, 10, and 11 are found to be 100:64:28. Despite the increased energy of the donorβacceptor interaction, dienophile 10 is 255 times less active in the reaction with 9,10-dimethylanthracene than 11. It is suggested that this is due to the significantly lower energy of Ο-bond cleavage in bicyclic dienophile 11, compared with monocyclic 10
Diels-Alder reaction rate in the solid state and the evidence of the location of molecular complexes between the reagents on the reaction pathway
The rate of reactions in the solid phase with uniform grinding of crystals of dienes, anthracene, and 9,10-dimethylanthracene, with dienophiles, tetracyanoethylene, N-phenylmaleimide, and 4-phenyl-1,2,4-triazoline-3,5-dione, has been studied. It was shown that, despite the high difference in the reaction rates in solution, the rates of these reactions in the solid phase are much closer. For anthracene-tetracyanoethylene and 9,10-dimethylanthracene-tetracyanoethylene pairs, it was concluded that their intermolecular complexes are on the reaction pathway
Towards the mechanism of DC electric field effect on flat premixed flames
The influence of a DC electric field on CH4/air flat flame characteristics was experimentally investigated. To understand the mechanism of the electric field influence on a flame a number of experiments were conducted: measurements of the flame burning velocities using the heat flux method, OH LIF measurements and measurements of the flame emission spectra. Two alternative explanations were proposed for an apparent increase in the burning rate induced by the electric field with positive polarity
Machine learning techniques for analysis of photometric data from the Open Supernova catalog
International audienceThe next generation of astronomical surveys will revolutionize our understandingof the Universe, raising unprecedented data challenges in the process. One ofthem is the impossibility to rely on human scanning for the identification ofunusual/unpredicted astrophysical objects. Moreover, given that most of theavailable data will be in the form of photometric observations, suchcharacterization cannot rely on the existence of high resolution spectroscopicobservations. The goal of this project is to detect the anomalies in the OpenSupernova Catalog (http://sne.space/) with use of machine learning. We willdevelop a pipeline where human expertise and modern machine learning techniquescan complement each other. Using supernovae as a case study, our proposal isdivided in two parts: the first developing a strategy and pipeline whereanomalous objects are identified, and a second phase where such anomalousobjects submitted to careful individual analysis. The strategy requires aninitial data set for which spectroscopic is available for training purposes, butcan be applied to a much larger data set for which we only have photometricobservations. This project represents an effective strategy to guarantee weshall not overlook exciting new science hidden in the data we fought so hard toacquire