Urethral stripping for delicate excision of dorsal accessory urethra

Duplication of the urethra is a rare anomaly. The accessory urethra may be dorsal or ventral, relative to the orthotopic urethra. Dorsal urethral duplication describes a normally located meatus and another accessory epispadiac meatus. Excision of the dorsal accessory urethra is usually curative, on the condition that the ventral  orthotopic urethra is normal. However, most reports recommend surgery only when there are significant functional or cosmetic problems, for fear of possible damage to the neurovascular bundle, or the continence mechanism during surgical excision. In this  report, we describe a modification for excising the dorsal accessory channel by stripping with minimal disturbance to the glans. With continuous refinement of the  surgical technique together with more reports confirming its safety, we believe that total excision of the dorsal accessory urethra can be offered to more patients as being the standard level of care.Keywords: accessory urethra, epispadias, urethral duplicatio

Analytical techniques in pharmaceutical analysis: A review

AbstractThe development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs. The review highlights a variety of analytical techniques such as titrimetric, chromatographic, spectroscopic, electrophoretic, and electrochemical and their corresponding methods that have been applied in the analysis of pharmaceuticals

Antidiabetic potential of Balanites Aegyptiaca kernel, flesh and their combination against streptozotocin-induced hyperglycemia in male rats

Purpose: To investigate the antidiabetic effect of Balanites aegyptiaca fruit kernel, flesh and their mixture on streptozocin (STZ)-induced diabetes in male rats.Methods: Six-week-old male Wistar rats were divided into nine groups: (1) control; (2) kernel; (3) flesh; (4) kernel + flesh; (5) STZ; (6) STZ + kernel; (7) STZ + flesh; (8) STZ + (kernel + flesh) and (9) STZ + metformin. Body weight changes, fasting blood glucose and serum insulin were assessed. Haematoxylin and Eosin (H & E) stained pancreas sections were examined microscopically for the number and status of β cells.Results: Administration of Balanites aegyptiaca kernel, flesh and their mixture significantly increased rat body weight compared to STZ-treated rats. In addition, the hypoglycemic effect of kernel, flesh and their mixture was noticed. In STZ-treated rats, administration of Balanites aegyptiaca kernel and kernel + flesh mixture significantly increased serum insulin (p < 0.05). Histopathological examination revealed a marked increase in the islets cell population with cellular activation, with superior effect in STZ + kernel group and STZ + (kernel + flesh) group.Conclusion: Balanites aegyptiaca showed a hypoglycemic effect which is comparable to metformin action. Further studies are required to determine its suitability as an anti-diabetic agent in humansKeywords: Balanites aegyptiaca, Diabetes, Histopathology, Insulin, Pancrea

On the energy-momentum tensor in non-commutative gauge theories

We study the properties of the energy-momentum tensor in non-commutative gauge theories by coupling them to a weak external gravitational field. In particular, we show that the stress tensor of such a theory coincides exactly with that derived from a theory where a Seiberg-Witten map has been implemented (namely, the procedure is commutative). Various other interesting features are also discussed.Comment: 3 page

Revue de processus ponctuels et synthèse de tests statistiques pour le choix d'un type de processus

Nous nous intéressons dans ce travail de recherche à la modélisation d'une série d'événements par la théorie des processus ponctuels temporels. Un processus ponctuel est défini comme étant un processus stochastique pour lequel chaque réalisation constitue une collection de points. Un grand nombre d'ouvrages traitent particulièrement de ces processus, cependant, il existe dans la littérature peu de travaux qui se préoccupent de l'analyse de séries d'événements. On identifie deux catégories de séries d'événements : une série d'un seul type d'événements et une série de plusieurs types d'événements.L'objectif de ce travail est de mettre en évidence les différents tests statistiques appliqués aux séries d'un seul ou de plusieurs types d'événements et de proposer une classification de ces tests. Nous présentons d'abord une revue de littérature des processus ponctuels temporels, accompagnée d'une classification de ces modèles. Par la suite, nous identifions les tests statistiques de séries d'un seul type d'événements et nous examinons leur applicabilité pour une série de deux ou de plusieurs types d'événements. Les tests statistiques identifiés sont répartis en quatre classes : analyse graphique, tests appliqués au processus de Poisson homogène et non homogène, tests appliqués au processus de renouvellement homogène et les tests de discrimination entre deux processus ponctuels. Ce travail est réalisé avec l'idée d'une application ultérieure dans le cadre de l'analyse du risque.Les résultats de cette recherche ont montré qu'il n'existe dans la littérature que des tests d'une série d'un seul type d'événements et ils sont, généralement, valables pour les processus ponctuels suivants : Poisson homogène et renouvellement homogène. L'application de ces tests aux séries de deux ou de plusieurs types d'événements est possible dans le cas où les événements sont définis par leurs nombres et leurs temps d'occurrence seulement, i.e. la durée de chaque événement n'est pas prise en considération.The design and management of hydraulic structures require a good knowledge of the characteristics of extreme hydrologic events such as floods and droughts, that may occur at the site of interest. Occurrences of such events may be modelled as temporal point processes. This modelling approach allows the derivation of various performance indices related to the design and operation of this infrastructure, as well as to the quantification and management of the associated risks. In this paper, we present statistical tests that may be applied for the modelling of a series of events by temporal point processes. A point process is defined as a stochastic process for which each realisation constitutes a series of points. Although a large body of literature dealt with temporal point processes, very few focused on the analysis of a series of events.In the present paper we identify two types of series of events: the first represents a series of only one type of event, and the second represents a series of several types of events. The main objective of this research is to comprehensively review the statistical tests applied to the series of one or several types of events and to propose a classification of these tests. This comprehensive review of statistical tests applied to point processes is carried out with the ultimate objective of applying these tests to real case studies within the framework of risk analysis. For example, an extended low-flow event constitutes a risk that may place a water resources system in a state of failure. Thus, it's important to identify and quantify this risk in order to ensure the optimal management of water resources. The modelling of the observed series of events by point processes can provide some statistical results, such as the distribution of number of events or the shape of the intensity function. These results are useful in a risk analysis framework, which includes two steps: risk evaluation and risk management. In the first part of the paper, a review and classification of the various temporal point processes are presented. These include the homogeneous and nonhomogeneous Poisson processes, the Negative Binomial process, the cluster point processes (such as the Neyman-Scott and the Bartlett-Lewis processes), the doubly stochastic Poisson processes, the self-exciting point processes, the homogeneous and nonhomogeneous renewal processes and the semi-markov processes. Also, we illustrate the various links and relationships that exist between these point processes. This classification is elaborated by considering the homogeneous Poisson process as the starting point. The simplicity and the wide use of this process in the statistical and hydrological literature justify this choice.In the second part of the paper, statistical tests of a series of one type of event are identified. A series of events may be characterised by the number of events, the occurrence times of the events or by the duration of each event. These characteristics are considered as random variables that must be represented by suitable statistical distributions. A series of events may also be characterised by the intensity function, which represents the instantaneous average rate of occurrence of an event. Clearly, the choice of the statistical distribution to model the number of events in a series or the intensity function depends on the nature of the observed data. For example, a stationary series of events may be represented by a constant intensity function. Thus, it is necessary to conduct an analysis of the observed series of the events, such as graphical analysis and statistical testing in order to select and validate the hypothesis underlying the point process model. The hypotheses that may be verified include trend analysis, homogeneity analysis, periodicity analysis, independence of intervals between events, and the adequacy of a given distribution for the number of events and for the time intervals separating events.In the third part, the applicability of the tests identified in the second part to the case of a series of two or more types of events is examined. In this part, our goal is to analyse the global point process (or the pooled output) obtained by the superposition of the p subsidiary point processes. The decomposition of the global process into p point processes necessitates an identification of each type of event, characterised generally by the number of occurrences and by the intervals between the successive events of the same type. We also examine the applicability of the statistical tests identified in the second part to the case where the global point process is characterised by the duration of each type of event. We investigate more specifically the case of two subsidiary point processes (p=2) where the two event types alternate in the time (an alternating point process). Finally, statistical tests identified in the second part are classified into four categories: tests based on graphical analysis; tests applied to the homogeneous and nonhomogeneous Poisson processes; tests applied to the homogeneous renewal process; and finally tests of discrimination between two specific processes. Theses tests of discrimination include the selection among the Poisson process and the renewal process, the Poisson process and the Binomial point process, and finally, the selection among these three point processes: Cox process, Neyman-Scott process and renewal process.The results of this research indicate that, in the past, mostly tests for a series of one type of event were presented in the literature. These tests are only valid for the following point processes: a homogenous Poisson process or a homogenous renewal process. The application of these tests to a series of two or several types of events is possible as long as these events are only described by their number and time of occurrence i.e. the duration of each event can not be taken into consideration. Otherwise, these tests are applicable to the alternating point process, which is characterised only by the number and the duration of the two types of events

Heterogeneous Catalysis to Drive the Waste-to-Pharma Concept: From Furanics to Active Pharmaceutical Ingredients

A perspective on the use of heterogeneous catalysis to drive the waste-to-pharma concept is provided in this contribution based on the conversion of furanics to active pharmaceutical ingredients (APIs). The provided overview of the concept in this perspective article has been exemplified for two key molecule examples: Ancarolol and Furosemide

Presacral tumors of the Currarino triad: teratomas or hamartomas?

Purpose: The aim was to elucidate the nature of the presacral tumors in the Currarino triad through studying their preoperative radiological anatomy and histopathology of excised specimens.Patients and methods: The study group included three operated cases of Currarino triad. All were women who presented with constipation and demonstrated the typical three components of the disease: anorectal anomaly, sacral bony defect, and presacral tumor. The histopathological slides of excised specimens (presacral tumors) were available for re-examination. For comparison, we included another ‘control’ group representing the standard sacrococcygeal teratomas (without vertebral or anorectal anomalies).Results: Histopathological examination of presacral tumors in the Currarino triad showed multicystic spaces lined by different types of epithelia mainly keratinized stratified squamous epithelium with focal areas of transitional epithelium. The underlying stroma showed fibrovascular connective tissue admixed with randomly arranged smooth muscle bundles. In contrast to the standard sacrococcygeal teratomas, neither skin adnexal structures nor heterologous mesenchymal tissues were observed; no immature elements could be detected.Conclusion: In the Currarino triad, several clinical and histopathological observations would suggest the excised presacral tumors to be developmental cysts (retrorectal hamartomas) rather than neoplastic teratomas.Keywords: Currarino triad, hamartoma, sacrococcygeal, tailgut, teratom

Knowledge Translation in Africa for 21(st) Century Integrative Biology: The "Know-Do Gap" in Family Planning with Contraceptive Use among Somali Women

Abstract An emerging dimension of 21(st) century integrative biology is knowledge translation in global health. The maternal mortality rate in Somalia is amongst the highest in the world. We set out to study the "know-do" gap in family planning measures in Somalia, with a view to inform future interventions for knowledge integration between theory and practice. We interviewed 360 Somali females of reproductive age and compared university-educated females to women with less or no education, using structured interviews, with a validated questionnaire. The mean age of marriage was 18 years, with 4.5 pregnancies per marriage. The mean for the desired family size was 9.3 and 10.5 children for the university-educated group and the less-educated group, respectively. Importantly, nearly 90% of the university-educated group knew about family planning, compared to 45.6% of the less-educated group. All of the less-educated group indicated that they would never use contraceptives, as compared to 43.5% of the university-educated group. Prevalence of contraceptive use among ever-married women was 4.3%. In the less-educated group, 80.6% indicated that they would not recommend contraceptives to other women as compared to 66.0% of the university-educated group. There is a huge gap between knowledge and practice regarding family planning in Somalia. The attendant reasons for this gap, such as level of education, expressed personal religious beliefs and others, are examined here. For primary health care to gain traction in Africa, we need to address the existing "know-do" gaps that are endemic and adversely impacting on global health. This is the first independent research study examining the knowledge gaps for family planning in Somalia in the last 20 years, with a view to understanding knowledge integration in a global world. The results shall guide policy makers, donors, and implementers to develop a sound family planning policy and program to improve maternal and child health in 21(st) century primary healthcare

Biliary duodenostomy: a safe and easier biliary drainage procedure after choledochal cyst excision

Background/purpose: The treatment of choice for choledochal cyst (CC) is complete excision followed by biliary–enteric anastomosis. Roux-en-Y biliary jejunostomy has been favored by most surgeons for decades, with satisfying results. The use of biliary duodenostomy (BD) is another simple alternative for biliary drainage after CC excision. Our intermediate-term outcomes of both biliary drainage procedures after CC excision are presented.Methods: We carried out a retrospective analysis of the outcome of CC management in children operated at the Pediatric Surgery Department of Ain-Shams University over 5 years, from January 2010.Results: A total of 23 cases (16 females) were included in this study. The mean age at operation was 4.02 ± 2.52 years. Twenty-one cases had type I and two cases had type III CC. Complete excision of the CC was performed in 22 cases, and partial excision with mucosectomy was performed in one case. Biliary–enteric anastomosis was performed with the duodenum in 18 patients (group I, BD) and with the jejunum in five cases (group II, Roux-en-Y biliary jejunostomy). The mean follow-up period was 53± 4.48 months. A patient from group II suffered from ascending cholangitis 6 months postoperatively.Conclusion: BD is a simple technique for biliary drainage after CC excision with no major complications at intermediate-term follow-up.Keywords: biliary obstruction, choledochal cyst, hepaticoduodenostomy, jaundic