VLBA Imaging of NGC 4261: Symmetric Parsec-scale Jets and the Inner Accretion Region

We observed the nuclear region of NGC 4261 (3C270) with the VLBA at two frequencies (1.6 and 8.4 GHz) simultaneously. We find that the position angle of the parsec-scale radio axis agrees, within the errors, with the position angle of the VLA-scale jet. Our observations also reveal basically symmetric radio structures at both 1.6 and 8.4 GHz. Analysis of these images shows that most of the central 10 pc of this source is not significantly affected by free-free absorption, even though HST images show that the nucleus contains a nearly edge-on disk of gas and dust on larger scales. Our highest angular resolution image shows a very narrow gap in emission, which we interpret as an absorption feature, just east of the radio core. This suggests that there may be a small, dense inner accretion disk whose width is less than 0.1 pc. If the inclination of this inner disk is close to that of the larger-scale HST disk it becomes optically thin to 8.4 GHz radiation at a deprojected radius of about 0.8 pc. The brightness of the pc-scale jets falls off very rapidly on both sides of the core, suggesting that the jets are rapidly expanding during the the first several pc of their travel. It appears that there is a small dense inner disk centered on the radio core (the base of the jets; less than 1 pc), a low density bubble filling most of the the inner several pc of the nucleus (within which the radio jets expand rapidly; ~10 pc), and a surrounding cool, higher density region (of which the HST absorption disk is part; tens to hundreds of pc) within which the transverse expansion of the radio jets, as implied by the rate of decrease in jet brightness, is nearly halted.Comment: Accepted by the Astrophysical Journa

VLBI Observations of a Complete Sample of Radio Galaxies V. 3C346 and 4C31.04: two Unusual CSS Sources

We present observations at 1.7 and 8.4 GHz of two Compact Steep Spectrum (CSS) sources from a complete sample of low-intermediate power radio galaxies. 3C346 shows an asymmetric structure with a one-sided ``jet'' and ``hot spot''. Present observations suggest that the classification of this source as a CSS is inappropriate, and that it is a common radio galaxy at a small angle to the line of sight. Its properties are in agreement with the predictions of unified schemes models. 4C31.04 shows more complex structure with the possibility of a centrally located flat spectrum core in between two close lobes. We suggest that this source could be a low redshift Compact Symmetric Object.Comment: 15 pages, LATEX, uuenconde ps figures To be published in the Astrophysical Journal, October 20th issu

Optimal Design for the Passive Control of Vibration Based on Limit Cycles

The optimal design of damping parameters for passive vibration control remains a challenge for both research and industrial applications. Here, we introduce a design methodology based on limit cycle analysis in concert with design optimization. A state-space representation is used to model the vibrational behavior converged to its limit cycle. The design approach is outlined and applied to mechanical systems undergoing periodic forces. This method is applicable to both vibration mitigation and energy harvesting, and examples of both are shown. We conclude with a summary of the results and an outlook for future developments and applications

Space VLBI Observations of 3C 279 at 1.6 and 5 GHz

We present the first VLBI Space Observatory Programme (VSOP) observations of the gamma-ray blazar 3C 279 at 1.6 and 5 GHz. The combination of the VSOP and VLBA-only images at these two frequencies maps the jet structure on scales from 1 to 100 mas. On small angular scales the structure is dominated by the quasar core and the bright secondary component `C4' located 3 milliarcseconds from the core (at this epoch). On larger angular scales the structure is dominated by a jet extending to the southwest, which at the largest scale seen in these images connects with the smallest scale structure seen in VLA images. We have exploited two of the main strengths of VSOP: the ability to obtain matched-resolution images to ground-based images at higher frequencies and the ability to measure high brightness temperatures. A spectral index map was made by combining the VSOP 1.6 GHz image with a matched-resolution VLBA-only image at 5 GHz from our VSOP observation on the following day. The spectral index map shows the core to have a highly inverted spectrum, with some areas having a spectral index approaching the limiting value for synchrotron self-absorbed radiation of 2.5. Gaussian model fits to the VSOP visibilities revealed high brightness temperatures (>10^{12} K) that are difficult to measure with ground-only arrays. An extensive error analysis was performed on the brightness temperature measurements. Most components did not have measurable brightness temperature upper limits, but lower limits were measured as high as 5x10^{12} K. This lower limit is significantly above both the nominal inverse Compton and equipartition brightness temperature limits. The derived Doppler factor, Lorentz factor, and angle to the line-of-sight in the case of the equipartition limit are at the upper end of the range of expected values for EGRET blazars.Comment: 11 pages, 6 figures, emulateapj.sty, To be published in The Astrophysical Journal, v537, Jul 1, 200

Ectopic c-kit Expression Affects the Fate of Melanocyte Precursors inPatchMutant Embryos

AbstractThePatch(Ph) mutation in the mouse, a deletion that includes the gene for PDGFRα, is a recessive lethal that exhibits a dominant pigment phenotype in heterozygotes. To assess whether thePhmutation acts cell-autonomously or non-autonomously on melanocyte development, we have examined the melanogenic potential of neural crest populations from normal and mutant crest cellsin vitroand the pattern of dispersal and survival of melanocyte precursors (MPs)in vivo.We report that trunk neural crest cells from homozygousPhembryos give rise to pigmented melanocytesin vitroin response to Steel factor (SlF).In vivo,homozygousPhembryos contain a subpopulation of crest-derived cells that express c-kit and tyrosinase-related protein-2 characteristic of MPs. These cells begin to migrate normally on the lateral crest migration pathway, but then fail to disperse in the dermal mesenchyme and subsequently disappear. Although dermal mesenchyme is adversely affected inPhhomozygotes, SlF mRNA expression by the cells of the dermatome is normal inPhembryos when neural crest-derived MPs start to migrate on the lateral pathway. In contrast, mRNA for the SlF receptor, c-kit, was observed to be ectopically expressed in somites and lateral mesenchyme in embryos carrying thePhmutation. Based on this ectopic expression of c-kit inPhmutant embryos, and the observed distribution of SlF protein in normal and mutant embryos, we suggest that competition for limited amounts of SlF localized on the lateral neural crest migration pathway alters melanocyte dispersal and survival

Physical properties of the jet in 0836+710 revealed by its transversal structure

Studying the internal structure of extragalactic jets is crucial for understanding their physics. The Japanese-led space VLBI project VSOP has presented an opportunity for such studies, by reaching baseline lengths of up to 36,000 km and resolving structures down to an angular size of $\approx 0.3$ mas at 5 GHz. VSOP observations of the jet in 0836+710 at 1.6 and 5 GHz have enabled tracing of the radial structure of the flow on scales from 2 mas to 200 mas along the jet and determination of the wavelengths of individual oscillatory modes responsible for the formation of the structure observed. We apply linear stability analysis to identify the oscillatory modes with modes of Kelvin-Helmholtz instability that match the wavelengths of the structures observed. We find that the jet structure in 0836+710 can be reproduced by the helical surface mode and a combination of the helical and elliptic body modes of Kelvin-Helmholtz instability. Our results indicate that the jet is substantially stratified and different modes of the instability grow inside the jet at different distances to the jet axis. The helical surface mode can be driven externally, and we discuss the implications of the driving frequency on the physics of the active nucleus in 0836+710.Comment: Accepted for publication in Astronomy & Astrophysics Letter

Variability in the X-ray Flux of Quasar 3C345: Inverse-Compton Emission from the Parsec-Scale Jet?

We present the results of the first systematic study of variability in the X-ray emission from the 'superluminal' quasar 3C 345. Its power-law 1-keV X-ray emission varies by a factor of two on a timescale of years, but with no change in spectral index, closely following the high-frequency radio flux. Using VLBI images, we show that one of the superluminal 'knots' in the jet (at a distance of ≈ 15 pc from the nucleus), rather than the nucleus, produces most of the observed X-rays, via the synchrotron self-Compton process. We show that this knot accelerates as it moves away from the nucleus, along along a path at ≈ 10° from the line of sight

Marching at the front and dragging behind: differential αVβ3-integrin turnover regulates focal adhesion behavior

Integrins are cell–substrate adhesion molecules that provide the essential link between the actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3-integrin dynamics in migrating cells using a green fluorescent protein–tagged β3-integrin chain. At the cell front, adhesion sites containing αVβ3-integrin remain stationary, whereas at the rear of the cell they slide inward. The integrin fluorescence intensity within these different focal adhesions, and hence the relative integrin density, is directly related to their mobility. Integrin density is as much as threefold higher in sliding compared with stationary focal adhesions. High intracellular tension under the control of RhoA induced the formation of high-density contacts. Low-density adhesion sites were induced by Rac1 and low intracellular tension. Photobleaching experiments demonstrated a slow turnover of β3-integrins in low-density contacts, which may account for their stationary nature. In contrast, the fast β3-integrin turnover observed in high-density contacts suggests that their apparent sliding may be caused by a polarized renewal of focal contacts. Therefore, differential acto-myosin–dependent integrin turnover and focal adhesion densities may explain the mechanical and behavioral differences between cell adhesion sites formed at the front, and those that move in the retracting rear of migrating cells

Biochemical profile of heifers with spontaneous humeral fractures suggest that protein-energy malnutrition could be an important factor in the pathology of this disease.

CAUL Read and Publish Agreement.CASE HISTORY: Serum and liver samples from 35, 2-year-old dairy heifers that had fractured one or both humeri post-calving between July and December 2019 were submitted to a diagnostic laboratory for analysis. Serum samples were analysed for albumin, β-hydroxybutyrate (BHB), creatinine, Ca, Mg, phosphate, non-esterified fatty acids (NEFA), and serum Cu concentration. Liver samples were analysed for liver Cu concentration. Data were compared to published reference intervals. Data values for heifers that prior to fracture had grazed fodder beet were also compared to values for those that had grazed pasture. CLINICAL FINDINGS: Sixty-nine percent of heifers with humeral fracture had serum creatinine concentrations below the lower value of the reference range (55-130 µmol/L). In 3/32 (9%) heifers, serum NEFA concentrations were increased above the reference value indicating body fat mobilisation (≥1.2 mmol/L for peri-partum cows) and in 20/35 (57%) heifers BHB serum concentrations were above the reference value indicating subclinical ketosis (≥1.1 mmol/L for peri-partum cows). In 24/35 (69%) heifers, liver Cu concentration was low (≤ 44 µmol/kg) or marginal (45-94 µmol/kg). The concentration of Cu in serum was low (≤ 4.5 µmol/L) in 2/33 (6%) heifers and marginal (4.6-7.9 µmol/L) in 5/33 (15%) heifers. There was moderate positive correlation between the logged concentrations of Cu in paired liver and serum samples, r(31) = 0.43; (95% CI = 0.1-0.79; p = 0.014). One heifer had a serum phosphate concentration below the lower limit of the reference range (< 1.10 mmol/L). For all heifers, the concentrations of albumin, Ca, and Mg in serum were within the reference intervals (23-38 g/L, 2.00-2.60 mmol/L, and 0.49-1.15 mmol/L respectively). Over winter, 15/35 (43%) heifers grazed predominantly pasture, 14/35 (40%) grazed fodder beet and 6/35 (17%) had a mixed diet. CLINICAL RELEVANCE: In some of these heifers with humeral fractures, there was evidence for protein and/or energy malnutrition in the form of elevated NEFA and BHB concentrations and low creatinine concentrations in serum. Liver Cu concentrations were also reduced in most affected heifers. However, the absence of a control group means it is not possible to determine if these are risk factors for fracture or features common to all periparturient heifers. Clinical trials and molecular studies are needed to determine the true contribution of Cu and protein-energy metabolism to the pathogenesis of spontaneous humeral fractures in dairy heifers. ABBREVIATIONS: BHB: ß-hydroxybutyrate; NEFA: Non-esterified fatty acids.Publishe

Age-related effects on postural control under multi-task conditions

Changes in postural sway and gait patterns due to simultaneously performed cognitive (CI) and/or motor interference (MI) tasks have previously been reported and are associated with an increased risk of falling in older adults