180,669 research outputs found
Kinetics of the local cellular response in the gastric lymph of immune and susceptible sheep to infection with Teladorsagia circumcincta
Effect of oxygen concentration on the structural and magnetic properties of LaRh1/2Mn1/2O3 thin films
Epitaxial LaRh1/2Mn1/2O3 thin films have been grown on (001)-oriented LaAlO3
and SrTiO3 substrates using pulsed laser deposition. The optimized thin film
samples are semiconducting and ferromagnetic with a Curie temperature close to
100 K, a coercive field of 1200 Oe, and a saturation magnetization of 1.7muB
per formula unit. The surface texture, structural, electrical, and magnetic
properties of the LaRh1/2Mn1/2O3 films was examined as a function of the oxygen
concentration during deposition. While an elevated oxygen concentration yields
thin films with optimal magnetic properties, slightly lower oxygen
concentrations result in films with improved texture and crystallinity
Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes
Extended Emission from Cygnus X-3 Detected with Chandra
We have discovered extended X-ray emission from the microquasar Cyg X-3 in
archival Chandra X-ray Observatory observations. A 5" wide structure lies
approximately 16" to the NE from the core point source and may be extended in
that direction. This angular scale corresponds to a physical extent of roughly
0.8 lyr, at a distance of 2.5 lyr from Cyg X-3 (assuming a 10 kpc distance).
The flux varied by a factor of 2.5 during the four months separating two of the
observations, indicating significant substructure. The peak 2-10 keV luminosity
was about 5e34 ergs/s. There may also be weaker, extended emission of similar
scale oppositely directed from the core, suggesting a bipolar outflow. This
structure is not part of the dust scattering halo, nor is it caused by the
Chandra point spread function. In this Letter we describe the observations and
discuss possible origins of the extension.Comment: Submitted to ApJ Letters. 5 pages, 2 figures (1 color). Uses
emulateap
Performance of the distributed central analysis in BaBar
The total dataset produced by the BaBar experiment at the Stanford Linear Accelerator Center (SLAC) currently comprises roughlydata events and an equal amount of simulated events, corresponding to 23 Tbytes of real data and 51 Tbytes simulated events. Since individual analyses typically select a very small fraction of all events, it would be extremely inefficient if each analysis had to process the full dataset. A first, centrally managed analysis step is therefore a common pre-selection (‘skimming’) of all data according to very loose, inclusive criteria to facilitate data access for later analysis. Usually, there are common selection criteria for several analysis. However, they may change over time, e.g., when new analyses are developed. Currently,$cal
Asking the experts : developing and validating parental diaries to assess children's minor injuries
The methodological issues involved in parental reporting of events in children's everyday lives are discussed with reference to the development and validation of an incident diary, collecting concurrent data on minor injuries in a community study of children under eight years old. Eighty-two mothers participated in a comparison over nine days of daily telephone interviews and structured incident diaries. Telephone methods resulted in more missing data, and participants in both groups expressed a preference for the diary method. This diary was then validated on a sample of 56 preschool and school-aged children by comparing injury recording by a research health visitor with that of their mothers. Each failed to report some injuries, but there was good agreement overall, and in descriptive data on injuries reported by both. Parental diaries have the potential to provide rich data, of acceptable validity, on minor events in everyday life
Local cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta
<b>Background</b><p></p>
The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions. Infection is particularly detrimental to lambs, in which it can cause pronounced morbidity and severe production losses. Due to the spreading resistance of this parasite to all classes of anthelmintic drugs, teladorsagiosis is having an increasingly severe impact on the sheep industry with significant implications for sheep welfare. Protective immunity develops slowly, wanes rapidly and does not appear to be as effective in young lambs. To investigate the development of immunity to T. circumcincta in sheep and lambs, we used cytokine transcript profiling to examine differences in the abomasal mucosa and gastric lymph node of naïve and previously infected sheep and lambs following challenge.<p></p>
<b>Results</b><p></p>
The results of these experiments demonstrated that the abomasal mucosa is a major source of cytokines during abomasal helminth infection. A local Th2-type cytokine response was observed in the abomasal mucosa and gastric lymph node of the previously infected sheep and lambs when compared with those of the naïve during the early stages of infection. In contrast, a pro-inflammatory component more was evident in the abomasal mucosa and gastric lymph node of the naïve sheep when compared with those of the previously infected, which was not observed in the lambs.<p></p>
<b>Conclusions</b><p></p>
The greater levels of Th2-type cytokine transcripts in both the abomasum and gastric lymph node of the previously infected compared with naïve sheep and lambs emphasises the importance of these mechanisms in the immune response to T. circumcincta infection. Younger lambs appear to be able to generate similar Th2-type responses in the abomasum suggesting that the increased morbidity and apparent lack of resistance in younger lambs following continuous or repeated exposure to T. circumcincta is unlikely to be due to a lack of appropriate Th2-type cytokine production
Spectrometric study of condensed phase species of thorium and palladium-based modifiers in a complex matrix for electrothermal atomic absorption spectrometry
The chemical and morphological transformations of condensed phase species of a thorium-based modifier were studied over the temperature range 200–2500 °C, without and with the presence of aluminium and silicon as matrix components, and in some instances, arsenic as an analyte element. A similar study was also conducted with palladium as the modifier, for comparison. Results were derived using scanning electron microscopy (SEM), energy dispersive (ED) X-ray spectrometry, Raman microanalysis and attenuated total reflectance (ATR) Fourier transform-infrared (FT-IR) spectrometry. Comparable results were found using pyrolytic and non-pyrolytic graphite platforms, with processes occurring at slightly higher temperatures on the pyrolytic graphite platform. With thorium as the modifier, metal oxides were the predominant species on the platform surface at relatively low temperatures (<1500 °C), whereas metal phases became prevalent at high temperatures, when thorium and aluminium tended to behave independently from one other. Some spatial variations in the composition of the salt residues on different regions of the platform were observed (from the region closest to the slot in the tube, to the region furthest from the slot). Nonetheless, thorium metal remained on the graphite platform to higher temperatures than did aluminium metal. In the presence of arsenic, the existence of mixtures of thorium and arsenic oxides, just before the appearance temperature of gas phase arsenic atoms, was confirmed by SEM studies, ED X-ray spectra and Raman microanalysis. This suggests that any modifying effect of thorium on arsenic occurs while the modifier is in the oxide phase rather than in the metal phase. The presence of silicon added as silica, did not influence significantly the thermochemical behaviour of mixtures of thorium and aluminium. However, coexistence of silicon and arsenic oxides at the appearance temperature of the atomic absorption signal of arsenic was obtained, confirming that silicon can act as an internal modifier for arsenic. In the presence of palladium, aluminium exhibited greater interaction with the modifier; consequently, aluminium metal was retained on the platform surface to higher temperatures than thorium, which could explain how interference effects of aluminium on e.g. arsenic are avoided or reduced. Similarly, there was evidence for interaction of palladium and arsenic in the reduced state. However, when aluminium and silicon were present, the transformation of the palladium oxide to the metallic state was affected, which could diminish the modifying benefits of palladium for arsenic in the presence of aluminium
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