Experimental investigation of pharmacokinetic properties and the accumulation of zinc when administrated nanoform of zinc hydroxide in a comparative aspect with zinc sulfate

The purpose of a preliminary assessment of the biological effect, a comparative study of nanoparticles using test cultures of bakery yeast, the results of which determined the level of inhibition, which was higher than 90%, compared with the figure for the zinc sulfate and the above 145% more compared to the zinc oxide. Investigation was performed on the pharmacokinetic characteristics of the 40 rabbits-males in comparison with that using zinc sulfate, in an enteral or intravenous administration at three dose levels: 10, 50 and 100 mg/k

Prevention as a method to ensure the health of children, adolescents and young people

This article describes the main aspects of prevention as a method to ensure the health of children, adolescents and young people. Identified the problem of lack of compliance with the requirements in preparation for sports.В данной статье рассмотрены основные аспекты профилактики как метод по обеспечению охраны здоровья детей, подростков и молодежи. Выявлена проблема отсутствия выполнения требований при подготовке к занятиям спортом

Technology economy human health, and challenges to their effectiveness

This article discusses the types of technologies saving human health and the main problems of efficiency and feasibility of their application.В данной статье рассматриваются типы технологий сберегающее здоровье человека и рассмотрены основные проблемы эффективности и целесообразности их применения

STRUCTURAL AND MORPHOLOGICAL PROPERTIES OF THE Ni – In SYSTEM

Structural and morphological changes were implemented in the Ni-In electrochemical system for the formation of structural traps in the form of indium intermetallides. The con-centration of In2(SO4)3 in the electrolyte for the synthesis of electrochemically nickel-indium composites was selected

X-ray Structural Properties of the Ni-In System

The direction of the research is the study of the relationship between structural-morphological and X-ray phase changes and the hydrogen content in the formed electrochemical systems. Indium-doped nickel is considered as a model system, as used instead of nickel to improve weldability [1]

Protective action of bienzyme conjugate of antioxidant biocatalysts in vivo

Endotoxin shock in rats led to intravenous bolus of bacterial lipopolysaccharide (LPS) was accompanied by oxidative stress and increase of NO level in livers, lungs, kidneys, hearts of animals. The intravenous administration of bienzyme superoxide dismutase - chondroitin sulphate - catalase conjugate (SOD-CHS-CAT) showed its anti-endotoxemia action in rats at preventive (before initiation of injury) and therapeutic (after start of injury) application during cytokine phase of injury and influence on further stages of the damage. The injection of antioxidant SOD-CHS-CAT conjugate in a therapeutic regime did not demonstrate significant alterations of No level in livers, lungs, kidneys, hearts of rats (as compared to indices of the rat group with LpS action only) and displayed protective action on the kidney function by altered urea and creatinine in blood. The therapeutic effect of SOD-CHS-CAT was demonstrated by increase in organism viability. The effects of intravenous injection of SOD-CHS-CAT in a rat model of endotoxin shock showed a variety in the activity of this conjugate in addition to prevention of NO conversion in peroxynitrite upon interaction with O2 superoxide radical. The results of accelerated normalization of arterial blood pressure and heart rate, a significant decrease in rat lethality because of using SOD-CHS-CAT conjugate indicate the importance of the determination of action mechanism of the cardiovascular injury models associated with other vasoactive agents besides NO. The further research of vascular damage pathogenesis and evaluation of its role in oxidative stress (time and place) are of paramount importance

Seasonal variations of the composition and structural characteristics of polysaccharides from the brown alga Costaria costata

was observed in mature alga

ПОЛИМОРФИЗМ ЛОКУСОВ ЦИТОПЛАЗМАТИЧЕСКОЙ МУЖСКОЙ СТЕРИЛЬНОСТИ ЛУКА РЕПЧАТОГО (ALLIUM CEPA L.) БЕЛОРУССКОЙ СЕЛЕКЦИИ

Studied are two DNA-markers of mitochondrial gene cob characterizing S- and N-cytoplasm, marker of mitochondrial region orfA501 with S- and T-cytoplasm, and two markers co-segregating with Ms or ms, nuclear genes which control the fertility of phenotypes with S-cytoplasm in the onion (Allium cepa L.) varieties developed in the Institute of Vegetable Growing.Изучены два ДНК-маркера митохондриального гена cob, характеризующие S- и N-типы цитоплазмы, маркер митохондриального региона orfA501, выделяющий S- и T-стерильные типы цитоплазмы и два маркера, косегрегирующие с Ms или ms, ядерными генами, контролирующими фертильность фенотипов с S-цитоплазмой, лука репчатого (Allium cepa L.) на примере сортов белорусской селекции

Novel Insights into the Diversity of Catabolic Metabolism from Ten Haloarchaeal Genomes

BACKGROUND: The extremely halophilic archaea are present worldwide in saline environments and have important biotechnological applications. Ten complete genomes of haloarchaea are now available, providing an opportunity for comparative analysis. METHODOLOGY/PRINCIPAL FINDINGS: We report here the comparative analysis of five newly sequenced haloarchaeal genomes with five previously published ones. Whole genome trees based on protein sequences provide strong support for deep relationships between the ten organisms. Using a soft clustering approach, we identified 887 protein clusters present in all halophiles. Of these core clusters, 112 are not found in any other archaea and therefore constitute the haloarchaeal signature. Four of the halophiles were isolated from water, and four were isolated from soil or sediment. Although there are few habitat-specific clusters, the soil/sediment halophiles tend to have greater capacity for polysaccharide degradation, siderophore synthesis, and cell wall modification. Halorhabdus utahensis and Haloterrigena turkmenica encode over forty glycosyl hydrolases each, and may be capable of breaking down naturally occurring complex carbohydrates. H. utahensis is specialized for growth on carbohydrates and has few amino acid degradation pathways. It uses the non-oxidative pentose phosphate pathway instead of the oxidative pathway, giving it more flexibility in the metabolism of pentoses. CONCLUSIONS: These new genomes expand our understanding of haloarchaeal catabolic pathways, providing a basis for further experimental analysis, especially with regard to carbohydrate metabolism. Halophilic glycosyl hydrolases for use in biofuel production are more likely to be found in halophiles isolated from soil or sediment

Oncofertility in women cured of hodgkin’s lymphoma as a child

The concept of risk-adapted therapy is a modern standard of choice for the treatment regimen of Hodgkin’s lymphoma in childhood.  As a rule, patients are distributed depending on the number of factors in the groups of low, intermediate and high risk with a  particular volume of the treatment program. The rational use of chemotherapy and radiation therapy can reduce the risk of gonadal  toxicity. Loss of oocytes in patients receiving Hodgkin’s lymphoma therapy in childhood is usually associated with systemic  chemotherapy and pelvic irradiation. A combination of inhibin B and FSH is proposed as a screening marker to assess the gonadotoxic  effects of chemotherapy, in both girls and boys