110 research outputs found
The transformation of the cultural memory through a prism of the Cyberspace
The paper considers the analysis of the cultural memory, which at the beginning of the XXI century underwent essential changes. The beginning of the memory research as a special phenomenon belongs to the Russian scientist, Nikolaj Miljukov [1] who has proved the emergence of social memory with the emergence of the intellectuals. In the article βIntellectuals and Historical Traditionβ, Miljukov emphasizes the importance of social memory for the forward positive development of society. Since Halbwachs social memory gets the status of the independent research project. At the end of the XIX century the main theoretical concepts of social memory are formed: cultural and historical, semiotics, informational, psychological. The beginning of the third millennium is marked by the basic change of research trajectories of social memory. Specific research projects are put in the forefront. Such articles can be used as an example. The main research objective consists in the identification of the sociocultural bases of the transformation of social memory research. In modern investigations of the cultural memory, this phenomenon finds the new paradigmatic characteristics, which are fully submitted in the modern Internet space
Modern requirements to preparation of professional and pedagogical personnel
The relevance of the researched problem is caused by the need of providing the educational organizations of the system of professional education with specialists in projecting and implementation of educational programs of training of workers and specialists of a middle link, and formation of a personnel resource for innovative productions. The purpose of the presented article consists in consideration of the discrepancies arising while introduction of the professional standard "Teacher of Vocational Training, Vocational Education and Further Vocational Education" and changes revelation of a pedagogical personnel which are necessary for improvement of preparation quality. The leading approach to the research of this problem is the system-based approach which allows us to reveal the discrepancies arising by the comparison of the professional standard and educational programs that are developed taking into account requirements of the educational standard for the direction of preparation Vocational Training (branch-wise). According to the analysis results, the option of adjustment of educational programs for the direction of preparation Vocational Training (branch-wise) is offered; it promotes improvement of preparation quality of pedagogical personnel for the system of professional education and further vocational education, and also the corporate educational organizations and innovative productions. The materials of the publication can be useful to heads of educational organizations while forming the personnel potential in educational institutions. Β© 2016 Zyryanova et al
Probing High Frequency Noise with Macroscopic Resonant Tunneling
We have developed a method for extracting the high-frequency noise spectral
density of an rf-SQUID flux qubit from macroscopic resonant tunneling (MRT)
rate measurements. The extracted noise spectral density is consistent with that
of an ohmic environment up to frequencies ~ 4 GHz. We have also derived an
expression for the MRT lineshape expected for a noise spectral density
consisting of such a broadband ohmic component and an additional strongly
peaked low-frequency component. This hybrid model provides an excellent fit to
experimental data across a range of tunneling amplitudes and temperatures
Dynamics of Josephson junctions and single-flux-quantum networks with superconductor-insulator-normal metal junction shunts
Within the framework of the microscopic model of tunneling, we modelled the
behavior of the Josephson junction shunted by the
Superconductor-Insulator-Normal metal (SIN) tunnel junction. We found that the
electromagnetic impedance of the SIN junction yields both the
frequency-dependent damping and dynamic reactance which leads to an increase in
the effective capacitance of the circuit. We calculated the dc I-V curves and
transient characteristics of these circuits and explained their quantitative
differences to the curves obtained within the resistively shunted junction
model. The correct operation of the basic single-flux-quanta circuits with such
SIN-shunted junctions, i.e. the Josephson transmission line and the toggle
flip-flop, have also been modelled.Comment: 8 pages incl. 7 figure
Single flux quantum circuits with damping based on dissipative transmission lines
We propose and demonstrate the functioning of a special Rapid Single Flux
Quantum (RSFQ) circuit with frequency-dependent damping. This damping is
achieved by shunting individual Josephson junctions by pieces of open-ended RC
transmission lines. Our circuit includes a toggle flip-flop cell, Josephson
transmission lines transferring single flux quantum pulses to and from this
cell, as well as DC/SFQ and SFQ/DC converters. Due to the desired
frequency-dispersion in the RC line shunts which ensures sufficiently low noise
at low frequencies, such circuits are well-suited for integrating with the
flux/phase Josephson qubit and enable its efficient control.Comment: 6 pages incl. 6 figure
Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia
In mammals, DNA methylation is necessary for the maintenance of genomic stability, gene expression regulation, and other processes. During malignant diseases progression, changes in both DNA methylation patterns and DNA methyltransferase (MTase) genes are observed. Human de novo MTase DNMT3A is most frequently mutated in acute myeloid leukemia (AML) with a striking prevalence of R882H mutation, which has been extensively studied. Here, we investigate the functional role of the missense mutations (S714C, R635W, R736H, R771L, P777R, and F752V) found in the catalytic domain of DNMT3A in AML patients. These were accordingly mutated in the murine Dnmt3a catalytic domain (S124C, R45W, R146H, R181L, P187R, and F162V) and in addition, one-site CpG-containing DNA substrates were used as a model system. The 3-15-fold decrease (S124C and P187R) or complete loss (F162V, R45W, and R146H) of Dnmt3a-CD methylation activity was observed. Remarkably, Pro 187 and Arg 146 are not located at or near the Dnmt3a functional motives. Regulatory protein Dnmt3L did not enhance the methylation activity of R45W, R146H, P187R, and F162V mutants. The key steps of the Dnmt3a-mediated methylation mechanism, including DNA binding and transient covalent intermediate formation, were examined. There was a complete loss of DNA-binding affinity for R45W located in the AdoMet binding region and for R146H. Dnmt3a mutants studied in vitro suggest functional impairment of DNMT3A during pathogenesis
THE SEARCH FOR NEW MATERIALS FOR SOLID OXIDE FUEL CELLS
In this work world energy consumption analysis is presented. Development prospects of energy effective and environmentally friendly technologies namely SOFC are analyzed. Existence of new compounds with unique properties is shown.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΌΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² ΡΠ½Π΅ΡΠ³ΠΈΠΈ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ½Π΅ΡΠ³ΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠΈΡΡΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π’ΠΠ’Π. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Ρ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ
Instruments of State Regulation of Innovative Activity in the Russian Federation
Innovative policy of the state - it is the socio-economic policy. It reflects the investment activity in the state, which reflects the direction, goals, forms of state authority in the field of science and technology. The financial growth of the state is based on a combination of extensive and intensive factors. Under extensive factors mean weight gain used in the production of resources under intensive factors - an increase in resources and performance properties of their use. In modern times, the ability to finance growth through involvement in the turnover of new resources are extremely limited. As a consequence become crucial intense moments. A decisive impact on the macro-economic characteristics have innovation. They affect the social strength, on the environment, on the intensity of international technical cooperation, the degree of public safety and the competitiveness of the national economy in the world economy. Currently, the innovation process determines the chances of becoming a state. Innovative activity is characterized by complexity and high risk. To initiate innovation is insufficient availability of internal incentives and capabilities. Here, a decisive driving force can be external stimuli and in particular state aid.
Keywords: economic policy, innovation, government regulation
JEL Classifications: O30, G28, K2
Π€Π°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΎΡΠΈΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°ΡΡΡΠΈΡΠ° ΡΡΠ΅Π΄Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ
Objective: to perform cost-effectiveness analysis of the treatment for adult patients with psoriatic arthritis (PsA) with a Russian interleukin- 17Π inhibitor netakimab in comparison with other biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) and to evaluate the influence of the inclusion of netakimab in the therapy for PsA on the budget of the Russian healthcare system.Material and methods. The evaluation of cost-effectiveness was performed from the position of the Russian healthcare system for patients with moderate and severe PsA. The evaluation was performed based on the results of the network meta-analysis of the randomized clinical studies. The criterion of clinical effectiveness included the changes in the condition of the joints by the criteria of the American College of Rheumatology (ACR20, ACR50, and ACR70) and changes in skin symptoms by the index of the prevalence and severity of psoriasis (PASI 75 and PASI 90) with a recalculation into quality-adjusted life-year (QALY). The time horizon of the cost-effectiveness analysis was 2 years. The calculation was based on the registered prices and VAT. If there was an original drug and a biosimilar registered on the pharmaceutical market, the calculation was based on the median of the registered prices. The budget impact analysis of the influence of netakimab inclusion in the therapy for patients with PsA was performed considering the structure of the prescription of bDMARDs and tsDMARDs that was determined in the pharmaco-epidemiological study conducted in the Russian Federation in 2020. The analysis was performed for patients that received medication by the scheme of reimbursement. The time horizon of the study was 3 years old.Results. In the base-case analysis, the cost-effectiveness ratio for netakimab was 1.210 mln rub/QALY (by 66.2β88.5% lower than in cases when comparison drugs were used). The budget impact analysis showed that the inclusion of netakimab in the therapy for PsA could reduce the costs by 376.60 mln rub (21.1%). Considering budget saving, the number of additional patients that can be treated will increase by 26.7% within 3 years.Conclusion. Netakimab is characterized by higher cost-effectiveness in comparison with other bDMARDs (adalimumab, golimumab, guselkumab, ixekizumab, infliximab, secukinumab, ustekinumab, certolizumab pegol, etanercept) and tsDMARDs (apremilast, tofacitinib) prescribed in the Russian Federation for patients with PsA. The inclusion of netakimab in the therapy for PsA will reduce the financial burden on the healthcare system.Π¦Π΅Π»Ρ: ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΡΠΎΡΠΈΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ (ΠΡΠ) ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΠΌ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠΌ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-17Π Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±ΠΎΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ Π³Π΅Π½Π½ΠΎ-ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠ½ΡΠΌΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ (ΠΠΠΠ) ΠΈ ΡΠ°ΡΠ³Π΅ΡΠ½ΡΠΌΠΈ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π±Π°Π·ΠΈΡΠ½ΡΠΌΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ (ΡΡΠΠΠΠ) ΠΈ ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π±ΡΠ΄ΠΆΠ΅Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±Π° Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΡΠ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠ΅Π½ΠΊΡ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠ·ΠΈΡΠΈΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π΄Π»Ρ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΡΠ ΡΡΠ΅Π΄Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΡΠΈΡΠ΅ΡΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΡΡΡΠ°Π²ΠΎΠ² ΠΏΠΎ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ ΠΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΎΠΉ ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ² (ACR20, ACR50 ΠΈ ACR70), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠ½ΠΎΠΉ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΠΊΠΈ ΠΏΠΎ ΠΈΠ½Π΄Π΅ΠΊΡΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π° (PASI 75 ΠΈ PASI 90) Ρ ΠΏΠ΅ΡΠ΅ΡΡΠ΅ΡΠΎΠΌ Π² ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΆΠΈΠ·Π½ΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° (Π°Π½Π³Π». quality-adjusted life-year, QALY). ΠΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΠΎΡΠΈΠ·ΠΎΠ½Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β 2 Π³ΠΎΠ΄Π°. ΠΡΠΈ ΡΠ°ΡΡΠ΅ΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π»ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Π·Π°ΡΡΠ°ΡΡ Π½Π° Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ΅Π½ Ρ ΡΡΠ΅ΡΠΎΠΌ Π½Π°Π»ΠΎΠ³Π° Π½Π° Π΄ΠΎΠ±Π°Π²Π»Π΅Π½Π½ΡΡ ΡΡΠΎΠΈΠΌΠΎΡΡΡ. ΠΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π½Π° ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠ½ΠΊΠ΅ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°, Π½ΠΎ ΠΈ Π΄ΠΆΠ΅Π½Π΅ΡΠΈΠΊΠΎΠ² ΡΠ°ΡΡΠ΅Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ΅Π΄ΠΈΠ°Π½Ρ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ΅Π½. ΠΠ½Π°Π»ΠΈΠ· Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π±ΡΠ΄ΠΆΠ΅Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±Π° Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΡΠ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΡΡΡΠΊΡΡΡΡ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΠΠΠ ΠΈ ΡΡΠΠΠΠ, Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠΉ Π² ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΌ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ Π² 2020 Π³. ΠΠ½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π»ΡΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ. ΠΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΠΎΡΠΈΠ·ΠΎΠ½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β 3 Π³ΠΎΠ΄Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π±Π°Π·ΠΎΠ²ΠΎΠΌ Π²Π°ΡΠΈΠ°Π½ΡΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ Β«Π·Π°ΡΡΠ°ΡΡβΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΒ» Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±Π° β 1,210 ΠΌΠ»Π½ ΡΡΠ±./QALY (Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ ΠΏΡΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ, Π½Π° 66,2β88,5%). ΠΠ½Π°Π»ΠΈΠ· Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π±ΡΠ΄ΠΆΠ΅Ρ ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±Π° Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΡΠ Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΠ΄Π΅Π»Π°Π½Π½ΡΡ
Π΄ΠΎΠΏΡΡΠ΅Π½ΠΈΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΡΠ½ΠΈΠ·ΠΈΡΡ Π·Π°ΡΡΠ°ΡΡ Π½Π° 376,60 ΠΌΠ»Π½ ΡΡΠ±. (21,1%). ΠΡΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠΈ Π±ΡΠ΄ΠΆΠ΅ΡΠ° ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΡ
ΠΌΠΎΠΆΠ½ΠΎ Π±ΡΠ΄Π΅Ρ ΠΏΡΠΎΠ»Π΅ΡΠΈΡΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 3 Π»Π΅Ρ, ΡΠ²Π΅Π»ΠΈΡΠΈΡΡΡ Π½Π° 26,7%.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ΅ΡΠ°ΠΊΠΈΠΌΠ°Π± Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΠΠΠ (Π°Π΄Π°Π»ΠΈΠΌΡΠΌΠ°Π±ΠΎΠΌ, Π³ΠΎΠ»ΠΈΠΌΡΠΌΠ°Π±ΠΎΠΌ, Π³ΡΡΠ΅Π»ΡΠΊΡΠΌΠ°Π±ΠΎΠΌ, ΠΈΠΊΡΠ΅ΠΊΠΈΠ·ΡΠΌΠ°Π±ΠΎΠΌ, ΠΈΠ½ΡΠ»ΠΈΠΊΡΠΈΠΌΠ°Π±ΠΎΠΌ, ΡΠ΅ΠΊΡΠΊΠΈΠ½ΡΠΌΠ°Π±ΠΎΠΌ, ΡΡΡΠ΅ΠΊΠΈΠ½ΡΠΌΠ°Π±ΠΎΠΌ, ΡΠ΅ΡΡΠΎΠ»ΠΈΠ·ΡΠΌΠ°Π±Π° ΠΏΡΠ³ΠΎΠ»ΠΎΠΌ, ΡΡΠ°Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠΌ) ΠΈ ΡΡΠΠΠΠ (Π°ΠΏΡΠ΅ΠΌΠΈΠ»Π°ΡΡΠΎΠΌ, ΡΠΎΡΠ°ΡΠΈΡΠΈΠ½ΠΈΠ±ΠΎΠΌ), Π½Π°Π·Π½Π°ΡΠ°Π΅ΠΌΡΠΌΠΈ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ ΠΏΡΠΈ ΠΡΠ. ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΡΠ°ΠΊΠΈΠΌΠ°Π±Π° Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΡΠ ΠΏΠΎΠ²Π»Π΅ΡΠ΅Ρ Π·Π° ΡΠΎΠ±ΠΎΠΉ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π½Π°Π³ΡΡΠ·ΠΊΠΈ Π½Π° Π±ΡΠ΄ΠΆΠ΅Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ
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