908 research outputs found
Dynamics of platicons due to third-order dispersion
Dynamics of platicons caused by the third-order dispersion is studied. It is
shown that under the influence of the third-order dispersion platicons obtain
angular velocity depending both on dispersion and on detuning value. A method
of tuning of platicon associated optical frequency comb repetition rate is
proposed.Comment: 11 pages, 5 figure
To the practical design of the optical lever intracavity topology of gravitational-wave detectors
The QND intracavity topologies of gravitational-wave detectors proposed
several years ago allow, in principle, to obtain sensitivity significantly
better than the Standard Quantum Limit using relatively small anount of optical
pumping power. In this article we consider an improved more ``practical''
version of the optical lever intracavity scheme. It differs from the original
version by the symmetry which allows to suppress influence of the input light
amplitude fluctuation. In addition, it provides the means to inject optical
pumping inside the scheme without increase of optical losses.
We consider also sensitivity limitations imposed by the local meter which is
the key element of the intracavity topologies. Two variants of the local meter
are analyzed, which are based on the spectral variation measurement and on the
Discrete Sampling Variation Measurement, correspondingly. The former one, while
can not be considered as a candidate for a practical implementation, allows, in
principle, to obtain the best sensitivity and thus can be considered as an
ideal ``asymptotic case'' for all other schemes. The DSVM-based local meter can
be considered as a realistic scheme but its sensitivity, unfortunately, is by
far not so good just due to a couple of peculiar numeric factors specific for
this scheme.
From our point of view search of new methods of mechanical QND measurements
probably based on improved DSVM scheme or which combine the local meter with
the pondermotive squeezing technique, is necessary.Comment: 27 pages, 6 figure
Impact ionization fronts in Si diodes: Numerical evidence of superfast propagation due to nonlocalized preionization
We present numerical evidence of a novel propagation mode for superfast
impact ionization fronts in high-voltage Si -- structures. In
nonlinear dynamics terms, this mode corresponds to a pulled front propagating
into an unstable state in the regime of nonlocalized initial conditions. Before
the front starts to travel, field-ehanced emission of electrons from deep-level
impurities preionizes initially depleted base creating spatially nonuniform
free carriers profile. Impact ionization takes place in the whole high-field
region. We find two ionizing fronts that propagate in opposite directions with
velocities up to 10 times higher than the saturated drift velocity.Comment: 3 pages, 4 figure
Molecular genetic characteristics of gastric cancers from the surgeon’s point of view
Dubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394
http://ojs.ukw.edu.pl/index.php/johs/article/view/4063
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016.
MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW
V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2,
D. V. Raciborsky2, S. N. Lee2
1Odessa National Medical university
2Odessa Regional Oncology center
Summary
A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ).
Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins
Theory of superfast fronts of impact ionization in semiconductor structures
We present an analytical theory for impact ionization fronts in reversely
biased p^{+}-n-n^{+} structures. The front propagates into a depleted n base
with a velocity that exceeds the saturated drift velocity. The front passage
generates a dense electron-hole plasma and in this way switches the structure
from low to high conductivity. For a planar front we determine the
concentration of the generated plasma, the maximum electric field, the front
width and the voltage over the n base as functions of front velocity and doping
of the n base. Theory takes into account that drift velocities and impact
ionization coefficients differ between electrons and holes, and it makes
quantitative predictions for any semiconductor material possible.Comment: 18 pagers, 10 figure
Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center
The survival of patients with the locally advanced stage of stomach cancer
(SC), who underwent various variants of preventive lymphatic nodes
dissection, was considered. The survival of patients was compared with the
stage and T, N indexes. Lymphadenectomy D2 were effective and increased
cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo,
stage III A, and in groups of patients where D2 lymphadenectomy were
ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo,
stage IIIB. D2 were more efficient operation in the case of tumor serosa
invasion and invasion to the peritoneal cavity (SE) in the absence of multiple
metastases to the regional lymph nodes (N1 according to the 7th revision of
the classification - 1-2 metastatic lymph nodes), and when
the tumor infiltrated the surrounding organs (SI) and the presence of multiple
regional metastases, D2 lymphodissection did not gave positive results,
comparising with D1
Novel data according Will Roger`s phenomenon in stomach cancer patients
Mostly Will Roger`s phenomenon means existence of so-called "jumping" or "jumping over the stages"
regional metastases in the stomach cancer patients. N1 in the 6th edition means 16 regional lymph nodes
involvement, while the N1 seventh edition – only 1-2 of regional lymph nodes involvement. This means that
T1N1Mo \ 6th and T1N1Mo \ 7th - not quite the same, and the survival of the two groups will be different.
The study, made on the abdominal oncosurgical department of Odessa Regional Oncology Center, included
188 patients operated for gastric cancer in the period 2007-2011. The study included only radically treated
patients. Comparison of survival in patients with gastric cancer between 6th revision groups of 7th has been
reviewed. The classification mission is to provide differences in the survival rates between the groups.
Regression multivariate Cox analysis showed that 7th UICC classification showed different capability of
stratifying survival groups of UICC N classification (P \ 0.01)
Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients. Journal of Education
Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the
research in abdominal oncosurgical department of Odessa regional oncological dispensary. It
was retrospective, one-center, nonrandomized research. Volume of lymph node dissections
differed by quantity of lymph nodes to be removed. All patients were divided into three groups.
Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are
included in group of historical control. The main group includes 33 patients to whom D3 lymph
node dissections is executed and, finally, control group – 65 patients dissected up to the D2
volume. In all cases so-called lymph node dissections for principal reasons have been executed.
The multifactorial analysis of patients survival is implemented depending on a type of a lymph
node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the
tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev),
availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease
stage, SC at 60% of patients, represented with initially hematologicaly disseminated disease.
40% of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more
than 15 regional lymph nodes are involved. In the absence of a SC perinevral invasion appeared
to be the most precise predictive marker. The conclusion is made some brand new additional53
prognostic factors could play a crucial role in more accurate patients selection for expanded
lymph node dissections
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