939 research outputs found
Development of a mud transport model for the Scheldt estuary in the framework of LTV: phases 1 and 2
A long-lasting, complete hematologic and cytogenetic remission of chronic myelogenous leukemia after treatment with busulfan alone
A 44-year-old man suffering from cytogenetically and molecularly proven Philadelphia translocation-positive chronic myelogenous leukemia in chronic phase was treated with busulfan for 18 months and studied during a follow-up period of 13 years. Hematologically and cytogenetically, he attained a continuing complete remission, although at one point (9.5 years) at least, after attaining complete remission molecular analysis indicated the presence of minimal residual disease
Profiling the vendors of COVID‐19 related product on the Darknet: An observational study
Background
In a time of unprecedented global change, the COVID-19 pandemic has led to a surge in demand of COVID-19 vaccines and related certifications. Mainly due to supply shortages, counterfeit vaccines, fake documentation, and alleged cures to illegal portfolios, have been offered on darkweb marketplaces (DWMs) with important public health consequences. We aimed to profile key DWMs and vendors by presenting some in-depth case studies.
Methods
A non-systematic search for COVID-19 products was performed across 118 DWMs. Levels of activity, credibility, content, COVID-19 product listings, privacy protocols were among the features retrieved. Open web fora and other open web sources were also considered for further analysis of both functional and non functional DWMs. Collected data refers to the period between January 2020 and October 2021.
Results
A total of 42 relevant listings sold by 24 vendors across eight DWMs were identified. Four of these markets were active and well-established at the time of the study with good levels of credibility. COVID-19 products were listed alongside other marketplace content. Vendors had a trusted profile, communicated in English language and accepted payments in cryptocurrencies (Monero or Bitcoin). Their geographical location included the USA, Asia and Europe. While COVID-19 related goods were mostly available for regional supply, other listings were also shipped worldwide.
Interpretation
Findings emerging from this study rise important questions about the health safety of certain DWMs activities and encourage the development of targeted interventions to overcome such new and rapidly expanding public health threats.
Funding
CovSaf, National Research centre on Privacy, Harm Reduction and Adversarial Influence Online (REPHRAIN), Commonwealth Fund
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A Qrr Noncoding RNA Deploys Four Different Regulatory Mechanisms to Optimize Quorum-Sensing Dynamics
Quorum sensing is a cell-cell communication process that bacteria use to transition between individual and social lifestyles. In vibrios, homologous small RNAs called the Qrr sRNAs function at the center of quorum-sensing pathways. The Qrr sRNAs regulate multiple mRNA targets including those encoding the quorum-sensing regulatory components luxR, luxO, luxM, and aphA. We show that a representative Qrr, Qrr3, uses four distinct mechanisms to control its particular targets: the Qrr3 sRNA represses luxR through catalytic degradation, represses luxM through coupled degradation, represses luxO through sequestration, and activates aphA by revealing the ribosome binding site while the sRNA itself is degraded. Qrr3 forms different base-pairing interactions with each mRNA target, and the particular pairing strategy determines which regulatory mechanism occurs. Combined mathematical modeling and experiments show that the specific Qrr regulatory mechanism employed governs the potency, dynamics, and competition of target mRNA regulation, which in turn, defines the overall quorum-sensing response
Complete Genome Sequence of the Aerobic Facultative Methanotroph Methylocella tundrae Strain T4
Methylocella tundrae T4T is a facultative aerobic methanotroph which was isolated from an acidic tundra wetland and possesses only a soluble methane monooxygenase. The complete genome, which includes two megaplasmids, was sequenced using a combination of Illumina and Nanopore technologies. One of the megaplasmids carries a propane monooxygenase gene cluster
Spatial Light Modulators for the Manipulation of Individual Atoms
We propose a novel dipole trapping scheme using spatial light modulators
(SLM) for the manipulation of individual atoms. The scheme uses a high
numerical aperture microscope to map the intensity distribution of a SLM onto a
cloud of cold atoms. The regions of high intensity act as optical dipole force
traps. With a SLM fast enough to modify the trapping potential in real time,
this technique is well suited for the controlled addressing and manipulation of
arbitrarily selected atoms.Comment: 9 pages, 5 figure
Quantum Extremism: Effective Potential and Extremal Paths
The reality and convexity of the effective potential in quantum field
theories has been studied extensively in the context of Euclidean space-time.
It has been shown that canonical and path-integral approaches may yield
different results, thus resolving the `convexity problem'. We discuss the
transferral of these treatments to Minkowskian space-time, which also
necessitates a careful discussion of precisely which field configurations give
the dominant contributions to the path integral. In particular, we study the
effective potential for the N=1 linear sigma model.Comment: 11 pages, 4 figure
The RMS Survey: Mid-Infrared Observations of Candidate Massive YSOs in the Southern Hemisphere
Abridged abstract: The Red MSX Source (RMS) survey is an ongoing effort to
return a large, well-selected sample of massive young stellar objects (MYSOs)
within our Galaxy. A series of ground-based follow-up observations are being
undertaken in order to remove contaminant objects from our list of 2000
candidates, and to begin characterising these MYSOs. As a part of these
follow-up observations, high resolution (~1") mid-IR imaging aids the
identification of contaminant objects which are resolved (UCHII regions, PN) as
opposed to those which are unresolved (YSOs, evolved stars) as well as
identifying YSOs near UCHII regions and other multiple sources. We present 10.4
micron imaging observations for 346 candidate MYSOs in the RMS survey in the
Southern Hemisphere, primarily outside the region covered by the GLIMPSE
Spitzer Legacy Survey. These were obtained using TIMMI2 on the ESO 3.6m
telescope in La Silla, Chile. Our photometric accuracy is of order 0.05Jy, and
our astrometric accuracy is 0.8", which is an improvement over the nominal 2"
accuracy of the MSX PSC.Comment: 9 page paper accepted to A&A. Online data for table 2 and figure 1
will be available in the published online version of this paper via A&A. The
paper contains 7 figures and 3 table
Variability of residual fluxes of suspended sediment in a multiple tidal-inlet system: the Dutch Wadden Sea
CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy (vol 13, pg 261, 2008)
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