Minutes 1863

https://place.asburyseminary.edu/freemethodistminutesyearbooks/1002/thumbnail.jp

The Present Position & Future of the Manganese Industry with Special Reference to Indian Resources

Statistics are quoted which show that manganese ore production is tied directly with world steel production, but fluctuations in steel output affect Indian ore production much more than production from other sources. A steady and increased demand for manganese is likely to result from research and development into: 1'. Improvement of quality of the end product and concentration of the manganese metal content to reduce freight charges. 2. The technical advantages of manganese as an alloying constituent in steel and the replacement of the more expensive alloying constituents, such as nickel, by manganese in alloy steels. 3. The use of manganese in non-ferrous alloys with particular reference to alloying constituent which increase the stability of the ductile gammaphase of manganese. 4. Manganese as a coating to provide corrosion and abrasion resistance to steel and non-ferrous metals, particularly in those fields in which zinc and nickel are at present used. The formation of a research and development organization to promote the use of manganese is advocated

Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: preparation and characterisation

For almost two decades, scientists were exploring the use of nanoparticles as drug vesicles capable of protecting their cargo and deliver it to the target site while evading detection by the body. However, their translation to clinical use has been slower than expected. To a large degree, this is due to the difficulty to formulate the nanomaterial into a usable form, in which they retain their unique, size-dependent properties without aggregating into a bulk material. In this work, we describe a simple methodology for synthesising novel biodegradable microneedle systems infused with silica nanoparticles (SiNP). SiNP were doped with small library of model anti-cancer drugs or drug surrogates before being characterised and encapsulated into biodegradable microneedles. Detailed preparation and characterisation methods for both the nanoparticles and the microneedles-infused with nanoparticles is presented here. We demonstrated the distribution of the nanoparticles within the microneedle matrix in a uniform, un-aggregated form, which enabled the release of the nanoparticles in a sustained manner. Formulating nanomaterial into biodegradable, hydrogel-like microneedles showed to be effective in preserving their colloidal properties, whilst simultaneously enabling the transdermal delivery of the nanomaterial into the body. Although the concepts of nanoparticles and biodegradable microneedles have been researched individually, the combination of the two, to the best of our knowledge, offers a new pathway to nanomedicine-related applications

A significant statement: new outlooks on treatment documentation

Values-based conservation is an increasingly dominant theme in heritage conservation theory. It is less routine in the application of object conservation practice, where emphasis on the physical fabric of heritage prevails. Materials-based approaches pivot conservation decisions on assessments of object condition. Values-based approaches posit that conservation should seek to sustain and enhance heritage significance rather than arrest physical change. A values-based approach is also one where the value-judgements underlying conservation decisions are made explicit. To reflect this, a new treatment documentation format has been developed at the UCL Institute of Archaeology. The documentation procedure shifts the focal point from condition assessments to statements of significance. Within the professional setting, similar new documentation is being developed for light-based artworks at Glasgow Museums. Ultimately, using a value-based treatment report, the conservator can be aware of the reasoning behind treatment choices and be better equipped to make decisions that reflect an object’s values

Nanomedicines and microneedles: a guide to their analysis and application

The fast-advancing progress in the research of nanomedicine and microneedles application in the past two decades have suggested that the combination of the two concepts could help to overcome some of the challenges we are facing in healthcare. These include poor patient compliance with medication and the lack of appropriate administration forms that enable the optimal dose to reach the target site. Nanoparticles as drug vesicles can protect their cargo and deliver it to the target site, while evading the body’s defence mechanisms. Unfortunately, despite intense research on nanomedicine in the past 20 years, we still haven’t answered some crucial questions, e.g. about their colloidal stability in solution and their optimal formulation, which makes the translation of this exciting technology from lab bench to a viable product difficult. Dissolvable microneedles could be an effective way to maintain and stabilise nano-sized formulations, whilst enhancing the ability of nanoparticles to penetrate the stratum corneum barrier. Both concepts have been individually investigated fairly well and many analytical techniques for tracking the fate of the nanomaterial with their precious cargo, both in vitro and in vivo, have been established. Yet, to the best of our knowledge, a comprehensive overview of the analytical tools encompassing the concepts of microneedles and nanoparticles with specific and successful examples is missing. In this review, we have attempted to briefly analyse the challenges associated with nanomedicine itself but crucially, we provide an easy-to-navigate scheme of methods, suitable for characterisation and imaging the physico-chemical properties of the material matrix

Locating Hinemihi's People

The care of taonga (Maori treasures) outside the Maori community takes place within varying degrees of inter-cultural engagement, in which encounters with the past can be seen to be negotiated through the changing nature of personal and institutional relationships in the present. The desire to develop Hinemihi, the historic Maori meeting house at Clandon Park, as a functioning marae (ceremonial gathering place) has provided a challenge to conventional heritage conservation practice. A response to the conservation of Hinemihi has been to adapt practice developed by the Pouhere Taonga (New Zealand Historic Places Trust) for the conservation of historic marae. The success of this approach relies on the formation of an active and sustaina blemarae community. Therefore, a series of community-based events have been delivered to nurture the developing relationships between Hinemihi and her people, as an essential element of the conservation project. This has questioned the central role of Maori in the long term care of Hinemihi. As a result, the formation of ‘Hinemihi’s People’ is an attempt to develop a sustainable conservation community for Hinemihi at Clandon Park that reflects a spatially and temporally grounded reality, based on lived experiences

Altered White-Matter Microstructure in Conduct Disorder Is Specifically Associated with Elevated Callous-Unemotional Traits

Adolescents with conduct disorder (CD) and elevated callous-unemotional (CU) traits have been reported to present with a more severe and persistent pattern of antisocial behaviour than those with low levels of CU traits. However, relatively few studies have investigated whether there are differences in brain structure between these subgroups.We acquired diffusion tensor imaging data and used tract-based spatial statistics (TBSS) to compare adolescents with CD and high levels of CU traits (CD/CU+; n = 18, CD and low levels of CU traits (CD/CU-; n = 17) and healthy controls (HC; n = 32) on measures of fractional anisotropy (FA), axial (AD), radial (RD) and mean (MD) diffusivity. Compared to CD/CU- adolescents, those with CD/CU+ presented increased FA and reduced RD and MD (lower diffusivity) in several tracts including: body and splenium of the corpus callosum, right inferior longitudinal fasciculus, ILF; right inferior fronto-occipital fasciculus, IFOF; left superior longitudinal fasciculus, SLF; left cerebral peduncle, bilateral internal capsule, left superior and posterior corona radiata, bilateral thalamic radiation and left external capsule. In addition, relative to CD/CU- individuals, adolescents with CD/CU+ showed lower diffusivity (indexed by reduced RD and MD) in left uncinate fasciculus and bilateral fornix. Finally, relative to healthy controls, CD/CU+ individuals showed lower diffusivity (reduced RD) in the genu and body of the corpus callosum and left anterior corona radiata. These results suggest that CD/CU+ individuals present with white-matter microstructural abnormalities compared to both CD/CU- individuals and age-matched healthy controls. This finding is consistent with emerging evidence suggesting that CD/CU+ represents a distinct subtype of CD, and illustrates the importance of accounting for heterogeneity within CD populations

Faithfulness without sexual exclusivity: gendered interpretations of faithfulness in rural south-western Uganda, and implications for HIV prevention programmes

This article explores gendered meanings of both faithfulness and sexual exclusivity within intimate long-term relationships, and the implications for HIV prevention messaging. In 2011–12, in-depth interviews were conducted with a random sample of 50 men and women (52 per cent women) in long-term relationships in rural Uganda. Confirming prior research, we found that a double standard exists for sexual exclusivity, where men define faithfulness to mean strict sexual exclusivity by their wife, but women defined it as being for both partners. However, both men and women defined fidelity to imply continued support. Fidelity was perceived to be intact if a man continued to provide material support, despite not being sexually exclusive. These findings highlight the limitations of HIV prevention strategies that emphasise faithfulness, where faithfulness is not synonymous with sexual exclusivity.</jats:p

Perceived senior leadership opportunities in MNCs: The effect of social hierarchy and capital

Drawing on the structural perspective in organizational theory, this study develops a conceptual framework of the social hierarchy within the multinational corporation (MNC). We suggest that parent country nationals (PCNs), host country nationals (HCNs), and third country nationals (TCNs) occupy distinctively different positions in the social hierarchy, which are anchored in their differential control or access to various forms of capital or strategically valuable organizational resources. We further suggest that these positions affect employees’ perceptions of senior leadership opportunities, defined as the assessment of the extent to which nationality and location influence access to senior leadership opportunities. Using multilevel analysis of survey data from 2039 employees in seven MNCs, the study reveals two significant findings. First, HCNs and TCNs perceive that nationality and location influence access to senior leadership opportunities more than PCNs. Second, three moderating factors – gender, tenure, and education – increase the perception gaps between PCNs on the one hand and HCNs and TCNs on the other, although these results are inconsistent. These findings indicate that the structural position of PCNs, HCNs, and TCNs in the social hierarchy affect sense-making and perceptions of access to senior leadership opportunities