Sjogren's syndrome: apoptosis by anti-SSA and anti-SSB antibodies

The pathogenesis of the Sjogren's Syndrome (SjS) has not yet been completely defined. However, the cell-mediated immunity plays an important role and the apoptosis of the ductal and acinar epithelial cells is responsible of the glandular tissue damage, through the cytotoxic T-cells, particularly of the CD4+ subpopulation, by the release of proteases (such as perforin and granzyme B) and by the interaction of the Fas Ligand (FasL; CD95L) of the T-lymphocytes, with the Fas (Apo-1; CD95) of the epithelial cells. The apoptotic death of the epithelial cells is the autocrine Fas/FasL interaction also. The anti-SSA and anti-SSB antibodies are the immunological markers of the Sjogren's syndrome, but it is not yet understood if they have pathogenetic implications...

Estudos preliminares sobre o efeito da cafeína na duplicação cromossômica em plantas haplóides de cevada (Hordeum vulgare L.).

bitstream/CNPT-2010/40768/1/p-do109.pd

Viabilidade polínica como seleção assistida no programa de melhoramento genético de triticale.

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Oscillation-Based Spectroscopy for Cell-Culture Monitorization

Biological Impedance is a physical property related to the state and inherent evolution of biological samples. Among the existing impedance measurement methods, Oscillation-Based (OB) tests are a simple and smart solution to indirectly measure impedance correlated with the amplitude and frequency of the generated oscillation which are proportional to the sample under test. An OB test requires tuning of the system blocks to specifications derived from every measurement problem. The OB setup must be done to obtain the optimum measurement sensitivity for the specific constraints imposed by the system under test, electronic interfaces, and electrodes employed for test. This work proposes the extension of OB measurement systems to spectroscopy test, enabling a completely new range of applications for this technology without the restrictions imposed by setting a fixed frequency on the electrical oscillator. Some examples will be presented to the measurement of cell cultures samples, considering the corresponding circuit interfaces and electric models for the electrode-cell system. The proposed analysis method allows the selection of the best oscillator elements for optimum sensitivity range in amplitude and frequency oscillation values, when a specific cell culture is monitored for the OB system

RNA-Seq para análise de genes diferencialmente expressos em micrósporos de trigo.

Sendo o trigo (Triticum aestivum) uma das principais commodities agrícolas do mundo, técnicas de melhoramento genético são empregadas na busca contínua de melhores características agronômicas, nutricionais e de resistência a estresses bióticos e abióticos