Caprio, S.

D’Amore, M.

D’Amore, S.

Minenna, G.

Scagliusi, A.

Scagliusi, P.

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LEPTIN SERUM LEVELS IN PATIENTS AFFECTED BY SERONEGATIVE ARTHRITISG. Minenna1, S. D’Amore2, P. Scagliusi1, S. Caprio3, A. Scagliusi4, M. D’Amore1University of Bari, Bari, Italy1 DIMIMP, Section of Rheumatology2 DIMIMP, Section of Internal Medicine3 Department of Pathology4 Department of Clinica Medica, Immunological Clinic and Infectious Diseases, Section of DermatologyLeptin has an important role in the regulation of body weight and modulates immunity and inflammation. Apositive feedback mechanism has been described between tumor necrosis factor and leptin, and it hasbeen suggested that leptin potentiates inflammation in patients with rheumatoid arthritis. Aims of this study are to evaluate leptin serum concentration in patients affected by seronegative arthritisand to compare the results with the ones obtained by healthy population. 40 patients have been recruited affected by seronegative arthritis (M:F=14:26) with an average age of54,4 years (range 18-80), average disease duration of 3,5 years (range 1-6). Leptin concentration hasbeen measured by ELISA method both in patients then in healthy population of 80 subjects equally divid-ed between male and female and with same average age. The difference between the two consideredgroups has been analyzed using Student’s test. Leptin medium concentration has been 10,701 ng/ml with SD 9,718; while 5,358 ng/ml with SD 2,286 inhealthy population. The difference between the two considered groups is significant t=4,661, p<0,0001. The increase in leptin production during inflammation suggests that leptin is part of the cytokine cascadewhich governs the inflammatory-immune response and the host defense mechanism. However, both proand anti-inflammatory effects have been described for leptin according to the experimental model investi-gated. New studies with other variables will be indispensable for explaining the obtained result. Clinical Cases in Mineral and Bone Metabolism 2005; 2(3): 185-252 225BSTR CT (V Congresso CCMBM)  18/11/2005  15.59  Pagina 225FOR REVIEW ONLY© CIC EDIZIONI INTERNAZIONALI

Leptin serum levels in patients affected by seronegative arthritis

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Leptin serum levels in patients affected by seronegative arthritis

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