Assessment of pharmacological activity and bioavailability of the new derivative 1,3,4-thiadiazole

Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluate

Conditioned Unitary Transformation on biphotons

A conditioned unitary transformation ($90^o$ polarization rotation) is performed at single-photon level. The transformation is realized by rotating polarization for one of the photons of a polarization-entangled biphoton state (signal photon) by means of a Pockel's cell triggered by the detection of the other (idler) photon after polarization selection. As a result, polarization degree for the signal beam changes from zero to the value given by the idler detector quantum efficiency. This result is relevant to practical realization of various quantum information schemes and can be used for developing a new method of absolute quantum efficiency calibration

Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid

The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drug

Status of the FLUTE RF System Upgrade

FLUTE (Ferninfrarot Linac- Und Test-Experiment) is a compact versatile linac-based accelerator test facility at KIT. Its main goal is to serve as a platform for a variety of accelerator studies and to generate strong ultra-short THz pulses for photon science. It will also serve as an injector for a Very Large Acceptance compact Storage Ring (VLA-cSR), which will be realized at KIT in the framework of the compact STorage Ring for Accelerator Research and Technology (cSTART) project. To achieve acceleration of electrons in the RF photoinjector and LINAC (from FLUTE) with high stability, it is necessary to provide stable RF power. For this goal, an upgrade of the existing RF system design has been proposed and is currently being implemented. This contribution will report on the updated RF system design and the commissioning status of the new RF system components

Probing AGN with spectropolarimetry: accretion disk and SMBH parameters

The interaction of a supermassive black hole with the matter of an accretion disk in the presence of a magnetic field is the key mechanism of energy release in active galactic nuclei. However, determining the physical parameters of this system, such as the spin and mass of the black hole, the shape and parameters of the rotation of the accretion disk, and the geometry of the magnetic field in the accretion disk is a complex and not completely solved problem. We have previously shown, based on our numerical models, that these estimates can be obtained from just three parameters: the black hole mass, bolometric luminosity, and optical polarization. In this paper, we estimate the accretion disk and black hole parameters for a sample of 14 type 1 Seyfert galaxies. Using the spectropolarimetric data obtained by us, we selected only those objects in which the polarization of optical radiation is generated mainly by the mechanism in the accretion disk. Despite the small statistics, our results for such a sample are consistent with our previous conclusions and show a discrepancy between the disk magnetic field parameters and the classical Shakura-Sunyaev disk model.Comment: 9 pages, 5 figure

Local Volume dwarf KK242: radial velocity, SF region, and metallicity

KK242 is a LV dwarf of transition type residing in the void environment. Koda et al. present clear indications on its connection with Scd galaxy NGC6503. This implies the distance to KK242 of ~6.3 Mpc and its M_B = -10.5 mag. Its radial velocity, known from the Effelsberg radio telescope \HI\ observations, reveals, however, the difference with that of NGC6503, dV ~ 400 km/s. If real, this fact implies the substantial constraints on its origin. To clear-up the issue of KK242 radial velocity, we obtained with the SAO 6-m telescope spectra of its faint star-forming (SF) complex. H-alpha and H-beta emission is detected in two adjacent compact regions, the southern and northern, separated by ~2" (~60 pc). Their mean radial velocity is V_hel = -66 km/s, ~100 km/s lower than that of NGC6503. We use the HST Legacy Archive images and photometry of individual stars from the Extragalactic Distance Database, available for KK242, to identify in the SF complex the exciting hot stars, the probable BHeB and RHeB stars and a supernova remnant. We address, based on the possible range of its gas metallicity, the probable evolutionary paths of KK242. Using package Cloudy and parameters of the exciting B0V stars, we conclude that the observed flux ratio of [Sii] doublet to H-alpha is consistent with the value of 12+log(O/H) ~7.35+/-0.18 dex, expected for a stripped void dIrr galaxy.Comment: 15 pages, 8 figures, 4 tables, published at MNRA