Transition metal complexes with thiosemicarbazide-based ligands. Part 60. Reactions of copper(II) bromide with pyridoxal S-methylisothiosemicarbazone (PLITSC). Crystal structure of [Cu(PLITSC−H)H2O]Br•H2O

The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC−H)H2O]Br•H2O (1) as the first Cu(II) complex with monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br2] (2) and [Cu(PLITSC)Br(MeOH)]Br (3) were characterized by elemental analysis, IR and electronic spectra and also by the methods of thermal analysis, conductometry and magnetochemistry. [Projekat Pokrajisnkog sekretarijata za nauku i tehnoloski razvoj Vojvodine i Ministarstva nauke Republike Srbije, br. 172014

Functional Expression of Human Adenine Nucleotide Translocase 4 in Saccharomyces Cerevisiae

The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. The human genome encodes multiple ANT isoforms that are expressed in a tissue-specific manner. Recently a novel germ cell-specific member of the ANT family, ANT4 (SLC25A31) was identified. Although it is known that targeted depletion of ANT4 in mice resulted in male infertility, the functional biochemical differences between ANT4 and other somatic ANT isoforms remain undetermined. To gain insight into ANT4, we expressed human ANT4 (hANT4) in yeast mitochondria. Unlike the somatic ANT proteins, expression of hANT4 failed to complement an AAC-deficient yeast strain for growth on media requiring mitochondrial respiration. Moreover, overexpression of hANT4 from a multi-copy plasmid interfered with optimal yeast growth. However, mutation of specific amino acids of hANT4 improved yeast mitochondrial expression and supported growth of the AAC-deficient yeast on non-fermentable carbon sources. The mutations affected amino acids predicted to interact with phospholipids, suggesting the importance of lipid interactions for function of this protein. Each mutant hANT4 and the somatic hANTs exhibited similar ADP/ATP exchange kinetics. These data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1, 2 and 3 providing a basis for study of its unique adaptation to germ cells

Cognitive robots of human character: Towards development of anthropomimetic robots with human personality

It is expected in the future that Robots will be reliable partners of humans in accomplishing different activities and thereby to express high degree of mutual understanding, compatibility and coordination between each-other. In that sense, along with the advance physical abilities, personal robots will be required to perceive, understand and express (use) the emotions as well as to react in a socially accepted manner by enhancing in such a way their interaction with social environment. In a word, robot is expected to posses a character, i.e. personality traits like human as live model. Possessing of character is of great importance for robot-partners due to reason of better acceptance amongst the humans as well as in order to make robots to be able of better understanding people behavior. The fact proved is that high degree of interpersonal compatibility, emotive complementarity and mutual understanding within a team or group ensures better outcomes than the team consists of superior individuals of high intelligence quotients (IQs). People choose partners in a way to be complementary with them and ones that manifest in general sense high level of mutual understandings and agreements. On the other hand, people do not enjoy the opposed persons of incompatible or conflict character. From these reasons, we investigate in the paper the answers if possible and how to give robots different characters i.e. attributes of human personalities