Stepwise API usage assistance using n-gram language models

Reusing software involves learning third-party APIs, a process that is often time-consuming and error-prone. Recommendation systems for API usage assistance based on statistical models built from source code corpora are capable of assisting API users through code completion mechanisms in IDEs. A valid sequence of API calls involving different types may be regarded as a well-formed sentence of tokens from the API vocabulary. In this article we describe an approach for recommending subsequent tokens to complete API sentences using n-gram language models built from source code corpora. The provided system was integrated in the code completion facilities of the Eclipse IDE, providing contextualized completion proposals for Java taking into account the nearest lines of code. The approach was evaluated against existing client code of four widely used APIs, revealing that in more than 90% of the cases the expected subsequent token is within the 10-top-most proposals of our models. The high score provides evidence that the recommendations could help on API learning and exploration, namely through the assistance on writing valid API sentences.info:eu-repo/semantics/submittedVersio

Co-culture system of osteoblasts and endothelial cells, an in vitro strategy to enhance vascularization in bone regeneration

[Excerpt] For bone TE applications the formation of a prevascularized structure is not only required for the survival of seeded cells on scaffolds, but is also a fundamental process in bone formation and repair. In this work we describe an in vitro strategy consisting in the simultaneous culture of osteoblasts and endothelial cells (ECs) onto a starch-based fiber-mesh scaffold, aiming to accelerate the establishment of a vascular bed in the implanted construct. [...]info:eu-repo/semantics/publishedVersio

Economic Impact of Prosthetic Joint Infection - an Evaluation Within the Portuguese National Health System

Introduction: Prosthetic infection is a devastating complication of arthroplasty and carries significant economic burden. The objective of this study was to analyze the economic impact of prosthetic hip and knee infection in Portuguese National Health System. Material and Methods: Case-control study carried out from January 2014 to December 2015. The mean costs of primary arthroplasties and prosthetic revision surgeries for non-infectious reasons were compared with the costs of prosthetic infections treated with debridement and preservation of the prosthesis or with two-stage exchange arthroplasty.The reimbursement for these cases was also evaluated and compared with its real costs. Results: A total of 715 primary arthroplasties, 35 aseptic revisions, 16 surgical debridements and 15 revisions for infectious reasons were evaluated. The cost of primary arthroplasties was 3,230€ in the hips and 3,618€ in the knees. The cost of aseptic revision was 6,089€ in the hips and 7,985€ in the knees. In the cases treated with debridement and implant retention the cost was 5,528€ in the hips and 4,009€ in the knees. In cases of infections treated with a two-stage revision the cost was 11,415€ and 13,793€ for hips and knees, respectively. Conclusion: As far as we know this is the first study that analyzes the economic impact of prosthetic infection in the Portuguese context. Although direct compensation for treating infected cases is much lower than calculated costs, infected cases push the overall hospital case-mix-index upwards thus increasing financial compensation for the entire cohort of treated patients. This knowledge will allow for more informed decisions about health policies in the future.info:eu-repo/semantics/publishedVersio

Avaliação da Actividade Muscular com e sem utilização de calçado instável e aplicação de um desequilíbrio

Objectivo: Este estudo visa avaliar a influência de sapatilhas MBT na actividade electromiográfica do tibial anterior, gastrocnémio, recto femoral e bicípite femoral, aplicando um desequilíbrio. Metodologia: A amostra foi constituída por 30 indivíduos do sexo feminino, com idades entre os 21 e os 57 anos. Os dados foram recolhidos através de electromiografia, tendo sido utilizada a plataforma de forças e dinamómetro para monitorizar o desequilíbrio. Resultados: Não foram encontradas diferenças estatisticamente significativas no tempo de início de activação muscular com calçado MBT e descalço. Conclusão: O uso de MBT, comparando com descalço, não influenciou os tempos de início de activação muscular.Objective: The main purpose of this project were to study the infl uence of MBT in electromyographi c activity of, Tibialis Anterior, Gastrocnemius, Rectus femoris and Biceps femoris during an external pertubation . Metodology : 30 subjects (female) with ages between 21 and 57 years old participate in this study. EMG activities were recorded during an exte rnal perturbation by surface electromyography, and monitorized using a platform and a dynamometer to measure the force . Results: Results showed no statistically significative differences in the initial time muscular activation, comparing the use of MBT and with bare feet Conclusion: The use of MBT doesn’t influenciate the initial time of muscular activation

Exploring the outcomes of digital marketing on historic sites' visitor behaviour

Purpose – Digital communication and social media have an increasing importance in society and in tourism boosting. This study aims to analyse the role of digital marketing in the destination image and visitor loyalty of historic sites. Design/methodology/approach – Using a mixed-method approach combining survey data from 318 respondents and three in-depth interviews. Using structural equations modelling results reveals experience, satisfaction, image and loyalty are concepts to be considered by the destinations’ digital marketing promotion, as well as the increasing use of digital marketing by tourists, in the sense that tourists are increasing the habit of checking the opinion of others before scheduling their trip and gives them more importance, and a growing importance is given by tourists to the web/social networks of places they intend to visit. Findings – This study contributes to the theory on tourism digital marketing which can be transposed to organizations management in order to encourage discussion on the processes of capture, retention and loyalty of target audiences. Research limitations/implications – To enhance the importance of digital marketing in the process of the tourist development of the city, it is fundamental to define a clear strategy for attracting and responding to the greatest demand from cultural tourists who are increasingly interested in actively participating in learning experiences. Practical implications – The results show that digital communication and social media have an increasing importance in society and in tourism boosting and economy recovery. Social implications – The paper presents digital marketing as a possible factor in tourism development and social inclusion, advancing practical measures aimed at social justice through a fairer distribution of tourism revenues and the defence of historic centre residents’ way (i.e. Barcelos’), and quality of life. Originality/value – The authors suggest the development of a strategic digital marketing plan applied to the development and promotion of tourism in the city of Barcelos (Portugal), to complement the research presented here, thus contributing with a more practical perspective of the subject under study.info:eu-repo/semantics/acceptedVersio

Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone-starch scaffold and the in vitro development of vascularization

The reconstruction of bone defects based on cell-seeded constructs requires a functional microvasculature that meets the metabolic demands of the engineered tissue. Therefore, strategies that augment neovascularization need to be identified. We propose an in vitro strategy consisting of the simultaneous culture of osteoblasts and endothelial cells on a starch-based scaffold for the formation of pre-vascular structures, with the final aim of accelerating the establishment of a vascular bed in the implanted construct. Human dermal microvascular endothelial cells (HDMECs) were co-cultured with human osteoblasts (hOBs) on a 3D starch-based scaffold and after 21 days of culture HDMEC aligned and organized into microcapillary-like structures. These vascular-like structures evolved from a cord-like configuration to a more complex branched morphology, had a lumen and stained in the perivascular region for type IV collagen. Genetic profiling of 84 osteogenesis-related genes was performed on coculture vs. monoculture. Osteoblasts in co-culture showed a significant up-regulation of type I collagen and immunohistochemistry revealed that the scaffold was filled with a dense matrix stained for type I collagen. In direct contact with HDMEC hOBs secreted higher amounts of VEGF in relation to monoculture and the highest peak in the release profile correlated with the formation of microcapillary-like structures. The heterotypic communication between the two cell types was also assured by direct cell– cell contact as shown by the expression of the gap junction connexin 43. In summary, by making use of heterotypic cellular crosstalk this co-culture system is a strategy to form vascular-like structures in vitro on a 3D scaffold.M.I. Santos would like to acknowledge the Portuguese Foundation for Science and Technology (FCT) for her PhD scholarship (SFRH/BD/13428/2003). This work was partially supported by FCT through funds from POCTI and/or FEDER programs and by the European Union funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758). This work was carried out under the scope of the European NOE EXPERTISSUES (NMP3-CT-2004-500283)

Exonization of an Intronic LINE-1 Element Causing Becker Muscular Dystrophy as a Novel Mutational Mechanism in Dystrophin Gene

A broad mutational spectrum in the dystrophin (DMD) gene, from large deletions/duplications to point mutations, causes Duchenne/Becker muscular dystrophy (D/BMD). Comprehensive genotyping is particularly relevant considering the mutation-centered therapies for dystrophinopathies. We report the genetic characterization of a patient with disease onset at age 13 years, elevated creatine kinase levels and reduced dystrophin labeling, where multiplex-ligation probe amplification (MLPA) and genomic sequencing failed to detect pathogenic variants. Bioinformatic, transcriptomic (real time PCR, RT-PCR), and genomic approaches (Southern blot, long-range PCR, and single molecule real-time sequencing) were used to characterize the mutation. An aberrant transcript was identified, containing a 103-nucleotide insertion between exons 51 and 52, with no similarity with the DMD gene. This corresponded to the partial exonization of a long interspersed nuclear element (LINE-1), disrupting the open reading frame. Further characterization identified a complete LINE-1 (~6 kb with typical hallmarks) deeply inserted in intron 51. Haplotyping and segregation analysis demonstrated that the mutation had a de novo origin. Besides underscoring the importance of mRNA studies in genetically unsolved cases, this is the first report of a disease-causing fully intronic LINE-1 element in DMD, adding to the diversity of mutational events that give rise to D/BMD.The authors are grateful to the patient and his family for accepting to collaborate in this work. The authors also wish to thank Dr. Stefan White and Yavuz Ariyurek from the Leiden University Medical Center (Netherlands) for facilitating the Single Molecule Real Time (PacBio) sequencing work. A research grant was attributed to J.O. by “Fundo para a Investigação e Desenvolvimento do Centro Hospitalar do Porto” (Grant ref.: 336-13(196-DEFI/285-CES)). The work was also supported by the authors’ Institutions and in part by UMIB, which is funded by “Fundação para a Ciência e Tecnologia (FCT)” under the Pest-OE/SAU/UI0215/2014.info:eu-repo/semantics/publishedVersio

Aboriginal Women Against Violence Project Evaluation Report

In 2008 Joan Harrison’s Support Services for Women received funding under the National Community Crime Prevention Programme (NCCPP) in relation to the Aboriginal Women Against Violence Project. The overall aim of the project was ‘to address family violence in Aboriginal and Torres Strait Islander communities in Liverpool and Campbelltown areas’ (Attorney General’s Funding schedule). The project identified two specific strategies to achieve this general aim: to train local Aboriginal and Torres Strait Islander women to become trainer, mentors and advocates in their own communities;to establish an Aboriginal Women Against Violence Committee. This evaluation reports on the agreed outcomes identified in the funding agreement as well as identifying broader lessons arising from the project in relation to addressing violence in Aboriginal and Torres Strait Islander communities.Joan Harrison’s Support Services for Wome

Anatomical description of the aortic arch of a rare species “the giant armadillo” (Priodontes maximus; Kerr, 1792)

The giant armadillo (Priodontes maximus) is found in diverse habitats from South America. A female adult giant armadillo with a body mass of 45 kg was used. The animal was a victim of trampling on highway AC-40, at 70 km, near the municipality of Capixaba-Acre and the corpse donated to the Animal Anatomy Laboratory at Federal University of Acre (UFAC). The arterial system was filled with natural latex via the thoracic aorta in a direction opposite the blood flow to facilitate the description of the aortic arch and its side branches. The study was approved by CEUA/UFAC – no. 053/2015 and SISBIO no. 47124-1. The aortic arch issued side groups, which had the following sequence: brachycephalic trunk, left carotid artery, left subclavian artery. The brachycephalic trunk forked forming the right subclavian artery and the right common carotid artery. The arrangement allowed the whole carotid blood supply to the brain and surrounding structures present in the animal’s head. The subclavian arteries, of homologous way, originated the arteries: vertebral, thoracic, and cervical costocervical trunk. The aortic arch armadillo showed the same pattern as that described for the Euphractus sexcinctus and different from those reported for the Dasypus novemcinctus and Tamandua tetradactyla. In addition, the function assigned to each branch was the same regardless of the species with which it was compared