5,290 research outputs found
Haemogregarina sp. (Apicomplexa: Haemogregarinidae), Telorchis attenuata (Digenea: Telorchiidae) and Neoechinorhynchus emydis (Acanthocephala: Neoechinorhynchidae) from Map Turtles (Graptemys spp.), in Northcentral Arkansas
A legacy slope failure in Penlee Quarry - a warning to others
PublishedArticlePenlee Quarry is a large quarry in West Cornwall that has been in operation since the late 1880s. It was a major producer of aggregate, but since 2003 under new ownership, quarry operations have concentrated on maintenance and preparatory works for the recovery of armourstone and the eventual construction of a marina. The western face of this quarry was excavated between the 1950s and 1970s and is akin to other legacy slopes found at several older British quarries. The slope is up to 90m in height, has little benching and has shown increasing signs of instability since 2005. Initially instability was evidenced by rockfall and more recently by serious collapses that have indicated the need for appropriate geotechnical design of a new replacement slope. This paper sets out background and historical data and then considers investigations into the underlying mechanisms and rock structures that have contributed to instability and are relevant to the design of measures to overcome the potential for future significant ground movements. Methods to remotely assess the controlling joint sets are discussed and the rationale behind the excavated solution to facilitate future workings is outlined. High, over-steep rock faces with limited, ineffective benching and excessive bench heights that may be found in some older quarries, as at Penlee, are likely to become a matter of increasing concern. In addition the potential for major air blast or flow slide phenomena needs further investigation in these legacy slopes some of which are present in Southwest England
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation.
Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders. Preclinical maternal immune activation (MIA) models are powerful translational tools to investigate mechanisms underlying epidemiological links between infection during pregnancy and offspring neurodevelopmental disorders. Our previous studies documenting the emergence of aberrant behavior in rhesus monkey offspring born to MIA-treated dams extends the rodent MIA model into a species more closely related to humans. Here we present novel neuroimaging data from these animals to further explore the translational potential of the nonhuman primate MIA model. Nine male MIA-treated offspring and 4 controls from our original cohort underwent in vivo positron emission tomography (PET) scanning at approximately 3.5-years of age using [18F] fluoro-l-m-tyrosine (FMT) to measure presynaptic dopamine levels in the striatum, which are consistently elevated in individuals with schizophrenia. Analysis of [18F]FMT signal in the striatum of these nonhuman primates showed that MIA animals had significantly higher [18F]FMT index of influx compared to control animals. In spite of the modest sample size, this group difference reflects a large effect size (Cohen's d = 0.998). Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence-a hallmark molecular biomarker of schizophrenia. These results validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia and other neurodevelopmental disorders associated with prenatal immune challenge
Gastrointestinal Parasites of the Northern River Otter, Lontra canadensis (Carnivora: Mustelidae), from Arkansas
New Host and Geographic Distribution Records for the Fish Leech Myzobdella reducta (Meyer, 1940) (Hirudinida: Piscicolidae)
GPR30 is necessary for estradiol-induced desensitization of 5- HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus
Estrogen therapy used in combination with selective serotonin reuptake inhibitor (SSRI) treatment improves SSRI efficacy for the treatment of mood disorders. Desensitization of serotonin 1A (5-HT1A) receptors, which takes one to two weeks to develop in animals, is necessary for SSRI therapeutic efficacy. Estradiol modifies 5-HT1A receptor signaling and induces a partial desensitization in the paraventricular nucleus (PVN) of the rat within two days, but the mechanisms underlying this effect are currently unknown. The purpose of this study was to identify the estrogen receptor necessary for estradiol-induced 5-HT1A receptor desensitization. We previously showed that estrogen receptor β is not necessary for 5-HT1A receptor desensitization and that selective activation of estrogen receptor GPR30 mimics the effects of estradiol in rat PVN. Here, we used a recombinant adenovirus containing GPR30 siRNAs to decrease GPR30 expression in the PVN. Reduction of GPR30 prevented estradiol-induced desensitization of 5-HT1A receptor as measured by hormonal responses to the selective 5-HT1A receptor agonist, (+)8-OH-DPAT. To determine the possible mechanisms underlying these effects, we investigated protein and mRNA levels of 5-HT1A receptor signaling components including 5-HT1A receptor, Gαz, and RGSz1. We found that two days of estradiol increased protein and mRNA expression of RGSz1, and decreased 5-HT1A receptor protein but increased 5-HT1A mRNA; GPR30 knockdown prevented the estradiol-induced changes in 5-HT1A receptor protein in the PVN. Taken together, these data demonstrate that GPR30 is necessary for estradiol-induced changes in the 5-HT1A receptor signaling pathway and desensitization of 5-HT1A receptor signaling
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