Jig protects transistors from heat while tinning leads

In tinning transistor leads, an aluminum jig is used to dip the leads into the molten tin. The jigs mass shunts excess heat given off by the molten tin before it reaches and damages the transistor body

Covering Kids & Families Evaluation: Public Coverage Versus No Coverage for Children: Perceptions and Experiences of Parents in Four Cities

Based on interviews, examines the perceptions and experiences that shape parents' decisions on enrolling their children in Medicaid and State Children's Health Insurance Programs. Considers remaining challenges, including language barriers

A State Dependent Regime Switching Model of Dynamic Correlations

Replaced with revised version of paper 07/29/09.dynamic correlations, regime switching, state dependent probabilities, thresholds, spillovers, Research Methods/ Statistical Methods,

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status

Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have identified eukaryotic initiation factor (eIF) 4A as a direct molecular target of rocaglates. eIF4A is the RNA helicase subunit of eIF4F, a complex that mediates cap-dependent ribosome recruitment to mRNA templates. The eIF4F complex has been implicated in tumor initiation and maintenance through elevated levels or increased phosphorylation status of its cap-binding subunit, eIF4E, thus furthering the interest toward developing rocaglates as antineoplastic agents. Recent experiments have indicated that rocaglates also interact with prohibitins 1 and 2, proteins implicated in c-Raf-MEK-ERK signaling. Because increased ERK signaling stimulates eIF4E phosphorylation status, rocaglates are also expected to inhibit eIF4E phosphorylation status, a point that has not been thoroughly investigated. It is currently unknown whether the effects on translation observed with rocaglates are solely through eIF4A inhibition or also a feature of blocking eIF4E phosphorylation. Here, we show that rocaglates inhibit translation through an eIF4E phosphorylation-independent mechanism.P50 GM067041 - NIGMS NIH HHS; R01 GM073855 - NIGMS NIH HHS; GM-067041 - NIGMS NIH HHS; MOP-106530 - Canadian Institutes of Health Researc

Low-Cost Electronic Microwave Calibration for Rapid On-Line Moisture Sensing of Seedcotton

In order to improve rapid on-line moisture sensing of seedcotton in cotton gins, a means by which to establish a reliable low-cost wide-band electronic calibration is critically needed. This calibration is needed to center the circuit due to changes in the internal signal delays and attenuation drift caused by temperature changes in the various system components and circuit elements. This research examines a hardware technique for use in conjunction with microwave reflective sensing probes having an extended bandwidth from 500 MHz through 2.5 GHz. This new technique was validated experimentally against known electrical propagation delay standards. Results of the measured propagation delay with this type of automatic electronic calibration method was found to agree with results using a vector network analyzer with a traditional S11 single port error correction calibration methodology to within 4% of the measurement, 95% confidence, with a standard error of +/− 18.6 ps for the delay measurements. At this level of performance, the proposed low-cost technique exhibits superior performance, over the typical geosciences time-domain reflectometer “TDR”, instruments in common use in soil moisture testing and is suitable for use in cotton gin moisture sensing

Judicial Review of Zoning Adminstration

This discussion will focus on the role of the courts in zoning administration judicial review. More specifically, the limitations of that role, as it is now employed, will be examined with a suggested alternative. However, beforye a meaningful explanation of that topic can be undertaken it is necessary to provide a brief description of the zoning procedure before judicial review is summoned into the fray. For this reason, the initial portion of this comment is devoted to a general discussion of the source of the municipality\u27s authority to promulgate zoning ordinances, and the makeup and function of the local zoning board. Provided with this background, one should be better able to appreciate the problems encountered by the courts when judicial review is applied

Alien Registration- Pelletier, Marie A. (South Portland, Cumberland County)

https://digitalmaine.com/alien_docs/20322/thumbnail.jp

Alien Registration- Pelletier, Marie A. (Brunswick, Cumberland County)

https://digitalmaine.com/alien_docs/31590/thumbnail.jp

Synthesis of aza-rocaglates via ESIPT-mediated (3+2) photocycloaddition

Synthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported. The route features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate. A continuous photoflow reactor was utilized for photocycloadditions. An array of compounds bearing the hexahydrocyclopenta[b]indole core structure was synthesized and evaluated in translation inhibition assays.R01 CA175744 - NCI NIH HHS; R01 GM073855 - NIGMS NIH HHS; R24 GM111625 - NIGMS NIH HHS; R35 GM118173 - NIGMS NIH HH