Gastro-enterologia a Catalunya. Àrees extrahospitalària i hospitalària (I)

Podeu consultar la segona part de l'article a: http://hdl.handle.net/2445/112309La situació de la digestologia, així com de les altres especialitats mèdiques, és objecte de continus estudis per part dels organismes administratius, tant centrals com autonòmics. Aquests estudis oficials, però, estan encaminats essencialment a quantificar l'assistència prestada. Aquest fet ha motivat a la Junta de la Societat Catalana de Digestologia a dur a terme una enquesta a fi de conèixer la situació en que es troben els digestòlegs catalans que presten assistència en l'àmbit extra-hospitalari. Així, s'ha considerat interessant de conèixer alguns aspectes, com el temps d'exercici dels professionals, quin tipus d'assistència presten (pública o privada), quines exploracions es fan i quina relació mantenen amb la Societat Catalana de Digestologia

Gastro-enterologia a Catalunya. Àrees extrahospitalària i hospitalària (II)

Podeu consultar la primera part de l'article a: http://hdl.handle.net/2445/106608La Societat Catalana de Digestologia es proposà de conéixer, el 1987, l'estat en què es trobava la gastroenterologia a Catalunya, ja que es disposaven de ben poques dades fins a aquells moments. ..

Lipoatròfia semicircular: protocol d'actuació 2015

Lipoatròfia semicircular; Prevenció; Procediments d'actuacióLipoatrophia semicircularis; Prevention; ProceduresLipoatrofia semicircular; Prevención; Procedimientos de actuaciónRecull detallat de les mesures preventives, de les actuacions en cas de lipoatròfia semicircular i tot allò relacionat amb l'obtenció de dades per a la notificació i seguiment de la malaltia

Transcriptional analysis of the HeT-A retrotransposon in mutant and wild type stocks reveals high sequence variability at Drosophila telomeres and other unusual features

<p>Abstract</p> <p>Background</p> <p>Telomere replication in Drosophila depends on the transposition of a domesticated retroelement, the <it>HeT-A </it>retrotransposon. The sequence of the <it>HeT-A </it>retrotransposon changes rapidly resulting in differentiated subfamilies. This pattern of sequence change contrasts with the essential function with which the <it>HeT-A </it>is entrusted and brings about questions concerning the extent of sequence variability, the telomere contribution of different subfamilies, and whether wild type and mutant Drosophila stocks show different <it>HeT-A </it>scenarios.</p> <p>Results</p> <p>A detailed study on the variability of <it>HeT-A </it>reveals that both the level of variability and the number of subfamilies are higher than previously reported. Comparisons between GIII, a strain with longer telomeres, and its parental strain Oregon-R indicate that both strains have the same set of <it>HeT-A </it>subfamilies. Finally, the presence of a highly conserved splicing pattern only in its antisense transcripts indicates a putative regulatory, functional or structural role for the <it>HeT-A </it>RNA. Interestingly, our results also suggest that most <it>HeT-A </it>copies are actively expressed regardless of which telomere and where in the telomere they are located.</p> <p>Conclusions</p> <p>Our study demonstrates how the <it>HeT-A </it>sequence changes much faster than previously reported resulting in at least nine different subfamilies most of which could actively contribute to telomere extension in Drosophila. Interestingly, the only significant difference observed between Oregon-R and GIII resides in the nature and proportion of the antisense transcripts, suggesting a possible mechanism that would in part explain the longer telomeres of the GIII stock.</p

Gastro-enterologia a Catalunya. Àrees extrahospitalària i hospitalària (I)

Podeu consultar la segona part de l'article a: http://hdl.handle.net/2445/112309La situació de la digestologia, així com de les altres especialitats mèdiques, és objecte de continus estudis per part dels organismes administratius, tant centrals com autonòmics. Aquests estudis oficials, però, estan encaminats essencialment a quantificar l'assistència prestada. Aquest fet ha motivat a la Junta de la Societat Catalana de Digestologia a dur a terme una enquesta a fi de conèixer la situació en que es troben els digestòlegs catalans que presten assistència en l'àmbit extra-hospitalari. Així, s'ha considerat interessant de conèixer alguns aspectes, com el temps d'exercici dels professionals, quin tipus d'assistència presten (pública o privada), quines exploracions es fan i quina relació mantenen amb la Societat Catalana de Digestologia

Gastro-enterologia a Catalunya. Àrees extrahospitalària i hospitalària (II)

Podeu consultar la primera part de l'article a: http://hdl.handle.net/2445/106608La Societat Catalana de Digestologia es proposà de conéixer, el 1987, l'estat en què es trobava la gastroenterologia a Catalunya, ja que es disposaven de ben poques dades fins a aquells moments. ..

Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease Papel del Helicobacter pylori en el cáncer gástrico tras gastrectomía parcial por úlcera benigna

Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5%) had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively). The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48) years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p < 0.07). No relationship was seen between type of gastric reconstruction (Billroth I or II) and rate of Helicobacter pylori detection. Conclusions: Helicobacter pylori infection is frequent in patients with previous gastrectomy for non-neoplastic disease. The results of the study suggest that Helicobacter pylori infection may play a role in gastric stump cancer.<br>Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5%) con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso) y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48) años. Se ha detectado un alto porcentaje de infección por Helicobacter pylori (100% en los pacientes con cáncer vs. 81,5% en los pacientes sin cáncer, p < 0,07). No se ha observado relación entre el tipo de reconstrucción gástrica (Billroth I o II) y el porcentaje de infección por Helicobacter pylori. Conclusiones: la infección por Helicobacter pylori es frecuente en pacientes gastrectomizados por patología benigna. Los resultados de este estudio sugieren que la infección por Helicobacter pylori podría jugar un papel en el cáncer gástrico

Specific Localization of the Drosophila Telomere Transposon Proteins and RNAs, Give Insight in Their Behavior, Control and Telomere Biology in This Organism

Drosophila telomeres constitute a remarkable exception to the telomerase mechanism. Although maintaining the same cytological and functional properties as telomerase maintain telomeres, Drosophila telomeres embed the telomere retrotransposons whose specific and highly regulated terminal transposition maintains the appropriate telomere length in this organism. Nevertheless, our current understanding of how the mechanism of the retrotransposon telomere works and which features are shared with the telomerase system is very limited. We report for the first time a detailed study of the localization of the main components that constitute the telomeres in Drosophila, HeT-A and TART RNAs and proteins. Our results in wild type and mutant strains reveal localizations of HeT-A Gag and TART Pol that give insight in the behavior of the telomere retrotransposons and their control. We find that TART Pol and HeT-A Gag only co-localize at the telomeres during the interphase of cells undergoing mitotic cycles. In addition, unexpected protein and RNA localizations with a well-defined pattern in cells such as the ovarian border cells and nurse cells, suggest possible strategies for the telomere transposons to reach the oocyte, and/or additional functions that might be important for the correct development of the organism. Finally, we have been able to visualize the telomere RNAs at different ovarian stages of development in wild type and mutant lines, demonstrating their presence in spite of being tightly regulated by the piRNA mechanism.This work was supported by a grant from the Spanish Ministry of Science and Innovation BFU2009-08318/BMC to EC. A National Institutes of Health grant R01GM067758 to ERG. EL-P acknowledges the following short term Fellowships: Ruth Lee Kennedy (Fulbright), EMBO short term, Journal Cell Science traveling Fellowship, and the Spanish Society of Genetics traveling fellowship.Peer reviewe