“You see yourself like in a mirror”: the effects of internet-mediated personal networks on body image and eating disorders

Body image issues associated with eating disorders consist of attitudinal and perceptual components: individuals’ dissatisfaction with body shape or weight, and inability to correctly assess body size. While prior research has mainly explored social pressure from media, fashion, and advertising, we aim to uncover how personal networks, also encompassing internet-mediated interactions, bear upon body image. We estimate these effects with data from a survey of users of websites on eating disorders, including indicators of their body size and body image, and maps of their networks of connections. A bivariate ordered probit accounts for the joint distribution of attitudinal and perceptual body image dimensions depending on network characteristics. Results, confirmed by in-depth interviews, provide evidence that personal networks affect body image concerns, and show that this influence varies significantly by body size. Personal networks, as may be formed also (but not only) online, can be conducive to positive body image development

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

Purpose: The current clinical practice in reproductive medicine should pose the couple at the centre of the diagnostic-therapeutic management of infertility and requires intense collaboration between the andrologist, the gynaecologist and the embryologist. The andrologist, in particular, to adequately support the infertile couple, must undertake important biological, psychological, economical and ethical task. Thus, this paper aims to provide a comprehensive overview of the multifaceted role of the andrologist in the study of male factor infertility. Methods: A comprehensive Medline, Embase and Cochrane search was performed including publications between 1969 and 2021. Results: Available evidence indicates that a careful medical history and physical examination, followed by semen analysis, always represent the basic starting points of the diagnostic work up in male partner of an infertile couple. Regarding treatment, gonadotropins are an effective treatment in case of hypogonadotropic hypogonadism and FSH may be used in men with idiopathic infertility, while evidence supporting other hormonal and nonhormonal treatments is either limited or conflicting. In the future, pharmacogenomics of FSHR and FSHB as well as innovative compounds may be considered to develop new therapeutic strategies in the management of infertility. Conclusion: To provide a high-level of care, the andrologist must face several critical diagnostical and therapeutical steps. Even though ART may be the final and decisive stage of this decisional network, neglecting to treat the male partner may ultimately increase the risks of negative outcome, as well as costs and psychological burden for the couple itself

L-carnitine fumarate, L-acetyl-carnitine and other components in male infertility: A pilot study of nutraceutics on sperm motility

The aim of this study was to evaluate any possible effect a combination of L-carnitine, fumarate, acetyl-Lcarnitine, fructose, citric acid, selenium, coenzime Q10, vitamin C, zinc, folic acid and vitamin B12 (Proxeed®) on sperm motility in a group of patients with unexplained asthenozoospermia. Thirty two patients received 1 sachet/day of Proxeed® for three months. Sperm parameters were studied before, during and after this treatment. Motility was also studied by the means of a computerized analysis (CASA system). The results of this study indicate that Proxeed® is able to increase sperm motility, both in a quantitative and qualitative manner. We conclude that oral administration of Proxeed® may improve sperm quality, at least in patients with idiopathic asthenozoospermia

Sperm cryopreservation during the SARS-CoV-2 pandemic

Purpose: Sperm cryopreservation is fundamental in the management of patients undergoing gonadotoxic treatments. Concerns have risen in relation to SARS-CoV-2 and its potential for testicular involvement, since SARS-CoV-2-positive cryopreserved samples may have unknown effects on fertilization and embryo safety. This study therefore aimed to analyze the safety of sperm cryopreservation for cancer patients after the onset of the pandemic in Italy, through assessment of the risk of SARS-CoV-2 exposure and viral RNA testing of semen samples. Methods: We recruited 10 cancer patients (mean age 30.5 ± 9.6 years) referred to our Sperm Bank during the Italian lockdown (from March 11th to May 4th 2020) who had not undergone a nasopharyngeal swab for SARS-CoV-2 testing. Patients were administered a questionnaire on their exposure to COVID-19, and semen samples were taken. Before cryopreservation, SARS-CoV-2 RNA was extracted from a 150 µl aliquot of seminal fluid in toto using QIAamp viral RNA kit (Qiagen) and amplified by a real time RT PCR system (RealStar SARS-CoV2 RT PCR, Altona Diagnostics) targeting the E and S genes. Results: The questionnaire and medical interview revealed that all patients were asymptomatic and had had no previous contact with COVID-19 infected patients. All semen samples were negative for SARS-CoV-2 RNA. Conclusion: This preliminary assessment suggests that a thorough evaluation (especially in the setting of a multidisciplinary team) and molecular confirmation of the absence of SARS-CoV-2 in seminal fluid from asymptomatic cancer patients may assist in ensuring the safety of sperm cryopreservation