Mental health and emotional well-being of students in further education - a scoping study

This study aimed to explore how FE colleges in England are engaging with and addressing the mental health needs of their young students (aged 16-19), both in terms of promoting positive mental health and emotional well-being and in responding to identified mental health problems

Unitarity of the infinite-volume three-particle scattering amplitude arising from a finite-volume formalism

In a previous publication, two of us derived a relation between the scattering amplitude of three identical bosons, $\mathcal M_3$, and a real function referred to as the {divergence-free} K matrix and denoted $\mathcal K_{\text{df},3}$. The result arose in the context of a relation between finite-volume energies and $\mathcal K_{\text{df},3}$, derived to all orders in the perturbative expansion of a generic low-energy effective field theory. In this work we set aside the role of the finite volume and focus on the infinite-volume relation between $\mathcal K_{\text{df},3}$ and $\mathcal M_3$. We show that, for any real choice of $\mathcal K_{\text{df},3}$, $\mathcal M_3$ satisfies the three-particle unitarity constraint to all orders. Given that $\mathcal K_{\text{df},3}$ is also free of a class of kinematic divergences, the function may provide a useful tool for parametrizing three-body scattering data. Applications include the phenomenological analysis of experimental data (where the connection to the finite volume is irrelevant) as well as calculations in lattice quantum chromodynamics (where the volume plays a key role).Comment: 19 pages, 4 figures, JLAB-THY-19-2945, CERN-TH-2019-07

The exposure history of the Apollo 16 site: An assessment based on methane and hydrolysable carbon

Nineteen soils from eight stations at the Apollo 16 landing site have been analyzed for methane and hydrolysable carbon. These results, in conjunction with published data from photogeology, bulk chemistry, rare gases, primordial and cosmogenic radionuclides, and agglutinate abundances have been interpreted in terms of differing contributions from three components-North and South Ray Crater ejecta and Cayley Plains material

Tunable subpicosecond electron bunch train generation using a transverse-to-longitudinal phase space exchange technique

We report on the experimental generation of a train of subpicosecond electron bunches. The bunch train generation is accomplished using a beamline capable of exchanging the coordinates between the horizontal and longitudinal degrees of freedom. An initial beam consisting of a set of horizontally-separated beamlets is converted into a train of bunches temporally separated with tunable bunch duration and separation. The experiment reported in this Letter unambiguously demonstrates the conversion process and its versatility.Comment: 4 pages, 5 figures, 1 table; accepted for publication in PR

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase

Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and simocyclinone D8, revealing two binding pockets that separately accommodate the aminocoumarin and polyketide moieties of the antibiotic. These are close to, but distinct from, the quinolone-binding site, consistent with our observations that several mutations in this region confer resistance to both agents. Biochemical studies show that the individual moieties of simocyclinone D8 are comparatively weak inhibitors of gyrase relative to the parent compound, but their combination generates a more potent inhibitor. Our results should facilitate the design of drug molecules that target these unexploited binding pockets