1,599 research outputs found
Isotopic difference in the heteronuclear loss rate in a two-species surface trap
We have realized a two-species mirror-magneto-optical trap containing a
mixture of Rb (Rb) and Cs atoms. Using this trap, we have
measured the heteronuclear collisional loss rate due to
intra-species cold collisions. We find a distinct difference in the magnitude
and intensity dependence of for the two isotopes Rb and
Rb which we attribute to the different ground-state hyperfine splitting
energies of the two isotopes.Comment: 4 pages, 2 figure
Brain Injury-Induced Synaptic Reorganization in Hilar Inhibitory Neurons Is Differentially Suppressed by Rapamycin
Following traumatic brain injury (TBI), treatment with rapamycin suppresses mammalian (mechanistic) target of rapamycin (mTOR) activity and specific components of hippocampal synaptic reorganization associated with altered cortical excitability and seizure susceptibility. Reemergence of seizures after cessation of rapamycin treatment suggests, however, an incomplete suppression of epileptogenesis. Hilar inhibitory interneurons regulate dentate granule cell (DGC) activity, and de novo synaptic input from both DGCs and CA3 pyramidal cells after TBI increases their excitability but effects of rapamycin treatment on the injury-induced plasticity of interneurons is only partially described. Using transgenic mice in which enhanced green fluorescent protein (eGFP) is expressed in the somatostatinergic subset of hilar inhibitory interneurons, we tested the effect of daily systemic rapamycin treatment (3 mg/kg) on the excitability of hilar inhibitory interneurons after controlled cortical impact (CCI)-induced focal brain injury. Rapamycin treatment reduced, but did not normalize, the injury-induced increase in excitability of surviving eGFP+ hilar interneurons. The injury-induced increase in response to selective glutamate photostimulation of DGCs was reduced to normal levels after mTOR inhibition, but the postinjury increase in synaptic excitation arising from CA3 pyramidal cell activity was unaffected by rapamycin treatment. The incomplete suppression of synaptic reorganization in inhibitory circuits after brain injury could contribute to hippocampal hyperexcitability and the eventual reemergence of the epileptogenic process upon cessation of mTOR inhibition. Further, the cell-selective effect of mTOR inhibition on synaptic reorganization after CCI suggests possible mechanisms by which rapamycin treatment modifies epileptogenesis in some models but not others
Fundamental noise limitations to supercontinuum generation in microstructure fiber
Broadband noise on supercontinuum spectra generated in microstructure fiber
is shown to lead to amplitude fluctuations as large as 50 % for certain input
laser pulse parameters. We study this noise using both experimental
measurements and numerical simulations with a generalized stochastic nonlinear
Schroedinger equation, finding good quantitative agreement over a range of
input pulse energies and chirp values. This noise is shown to arise from
nonlinear amplification of two quantum noise inputs: the input pulse shot noise
and the spontaneous Raman scattering down the fiber.Comment: 16 pages with 6 figure
Effects of Rapamycin Treatment on Neurogenesis and Synaptic Reorganization in the Dentate Gyrus after Controlled Cortical Impact Injury in Mice
Post-traumatic epilepsy (PTE) is one consequence of traumatic brain injury (TBI). A prominent cell signaling pathway activated in animal models of both TBI and epilepsy is the mammalian target of rapamycin (mTOR). Inhibition of mTOR with rapamycin has shown promise as a potential modulator of epileptogenesis in several animal models of epilepsy, but cellular mechanisms linking mTOR expression and epileptogenesis are unclear. In this study, the role of mTOR in modifying functional hippocampal circuit reorganization after focal TBI induced by controlled cortical impact (CCI) was investigated. Rapamycin (3 or 10 mg/kg), an inhibitor of mTOR signaling, was administered by intraperitoneal injection beginning on the day of injury and continued daily until tissue collection. Relative to controls, rapamycin treatment reduced dentate granule cell area in the hemisphere ipsilateral to the injury two weeks post-injury. Brain injury resulted in a significant increase in doublecortin immunolabeling in the dentate gyrus ipsilateral to the injury, indicating increased neurogenesis shortly after TBI. Rapamycin treatment prevented the increase in doublecortin labeling, with no overall effect on Fluoro-Jade B staining in the ipsilateral hemisphere, suggesting that rapamycin treatment reduced posttraumatic neurogenesis but did not prevent cell loss after injury. At later times post-injury (8-13 weeks), evidence of mossy fiber sprouting and increased recurrent excitation of dentate granule cells was detected, which were attenuated by rapamycin treatment. Rapamycin treatment also diminished seizure prevalence relative to vehicle-treated controls after TBI. Collectively, these results support a role for adult neurogenesis in PTE development and suggest that suppression of epileptogenesis by mTOR inhibition includes effects on post-injury neurogenesis
Geometric quantization of Hamiltonian actions of Lie algebroids and Lie groupoids
We construct Hermitian representations of Lie algebroids and associated
unitary representations of Lie groupoids by a geometric quantization procedure.
For this purpose we introduce a new notion of Hamiltonian Lie algebroid
actions. The first step of our procedure consists of the construction of a
prequantization line bundle. Next, we discuss a version of K\"{a}hler
quantization suitable for this setting. We proceed by defining a
Marsden-Weinstein quotient for our setting and prove a ``quantization commutes
with reduction'' theorem. We explain how our geometric quantization procedure
relates to a possible orbit method for Lie groupoids. Our theory encompasses
the geometric quantization of symplectic manifolds, Hamiltonian Lie algebra
actions, actions of families of Lie groups, foliations, as well as some general
constructions from differential geometry.Comment: 40 pages, corrected version 11-01-200
Universal Robotic Gripper based on the Jamming of Granular Material
Gripping and holding of objects are key tasks for robotic manipulators. The
development of universal grippers able to pick up unfamiliar objects of widely
varying shape and surface properties remains, however, challenging. Most
current designs are based on the multi-fingered hand, but this approach
introduces hardware and software complexities. These include large numbers of
controllable joints, the need for force sensing if objects are to be handled
securely without crushing them, and the computational overhead to decide how
much stress each finger should apply and where. Here we demonstrate a
completely different approach to a universal gripper. Individual fingers are
replaced by a single mass of granular material that, when pressed onto a target
object, flows around it and conforms to its shape. Upon application of a vacuum
the granular material contracts and hardens quickly to pinch and hold the
object without requiring sensory feedback. We find that volume changes of less
than 0.5% suffice to grip objects reliably and hold them with forces exceeding
many times their weight. We show that the operating principle is the ability of
granular materials to transition between an unjammed, deformable state and a
jammed state with solid-like rigidity. We delineate three separate mechanisms,
friction, suction and interlocking, that contribute to the gripping force.
Using a simple model we relate each of them to the mechanical strength of the
jammed state. This opens up new possibilities for the design of simple, yet
highly adaptive systems that excel at fast gripping of complex objects.Comment: 10 pages, 7 figure
Magneto-optical Trapping of Cadmium
We report the laser-cooling and confinement of Cd atoms in a magneto-optical
trap, and characterize the loading process from the background Cd vapor. The
trapping laser drives the 1S0-1P1 transition at 229 nm in this two-electron
atom and also photoionizes atoms directly from the 1P1 state. This
photoionization overwhelms the other loss mechanisms and allows a direct
measurement of the photoionization cross section, which we measure to be
2(1)x10^(-16)cm^(2) from the 1P1 state. When combined with nearby laser-cooled
and trapped Cd^(+) ions, this apparatus could facilitate studies in ultracold
interactions between atoms and ions.Comment: 8 pages, 11 figure
Airy processes and variational problems
We review the Airy processes; their formulation and how they are conjectured
to govern the large time, large distance spatial fluctuations of one
dimensional random growth models. We also describe formulas which express the
probabilities that they lie below a given curve as Fredholm determinants of
certain boundary value operators, and the several applications of these
formulas to variational problems involving Airy processes that arise in
physical problems, as well as to their local behaviour.Comment: Minor corrections. 41 pages, 4 figures. To appear as chapter in "PASI
Proceedings: Topics in percolative and disordered systems
Sub-Doppler spectroscopy of Rb atoms in a sub-micron vapor cell in the presence of a magnetic field
We report the first use of an extremely thin vapor cell (thickness ~ 400 nm)
to study the magnetic-field dependence of laser-induced-fluorescence excitation
spectra of alkali atoms. This thin cell allows for sub-Doppler resolution
without the complexity of atomic beam or laser cooling techniques. This
technique is used to study the laser-induced-fluorescence excitation spectra of
Rb in a 50 G magnetic field. At this field strength the electronic angular
momentum J and nuclear angular momentum I are only partially decoupled. As a
result of the mixing of wavefunctions of different hyperfine states, we observe
a nonlinear Zeeman effect for each sublevel, a substantial modification of the
transition probabilities between different magnetic sublevels, and the
appearance of transitions that are strictly forbidden in the absence of the
magnetic field. For the case of right- and left- handed circularly polarized
laser excitation, the fluorescence spectra differs qualitatively. Well
pronounced magnetic field induced circular dichroism is observed. These
observations are explained with a standard approach that describes the partial
decoupling of I and J states
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