542 research outputs found
Dissociative and double photoionization of CO2 from threshold to 90 A
The molecular photoionization, dissociative photoionization and double photoionization cross sections for CO2 were measured from their onsets down to 90 A by using various combinations of mass spectrometers (a coincidence time-of-flight mass spectrometer and a magnetic mass spectrometer) and light sources (synchrotron radiation, and glow and spark discharge). It is concluded that the one broad peak and the three shoulders in the total adsorption cross section curve between 640 and 90 A are caused completely by dissociative ionization processes. Several peaks observed in the cross section curve for the total fragmentation CO(+)3, O(+) and C(+) are compared with those in the photoelectron spectrum reported for CO2
Total and dissociative photoionization cross sections of N2 from threshold to 107 eV
The absolute cross sections for the production of N(+) and N2(+) were measured from the dissociative ionization threshold of 115 A. In addition, the absolute photoabsorption and photoionization cross sections were tabulated between 114 and 796 A. The ionization efficiencies were also given at several discrete wave lengths between 660 and 790 A. The production of N(+) fragment ions are discussed in terms of the doubly excited N2(+) states with binding energies in the range of 24 to 44 eV
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the endoplasmic reticulum and activation of the Unfolded Protein Response (UPR). Following chronic UPR activation, the transcription factor CHOP (GADD153/DDIT3) triggers cell death; however, the mechanisms linking the UPR or CHOP to hepatoceullular injury and inflammation in the pathogenesis of NASH are not well understood. Using HepG2 and primary human hepatocytes, we found that CHOP induces cell death and inflammatory responses following saturated free fatty acid exposure by activating NF-κB through a pathway involving IRAK2 expression, resulting in secretion of cytokines IL-8 and TNFα directly from hepatocytes. TNFα facilitates hepatocyte death upon exposure to saturated free fatty acids and secretion of both IL-8 and TNFα contribute to inflammation. Interestingly, CHOP/NF-κB signaling is not conserved in primary rodent hepatocytes. Our studies suggest that CHOP plays a vital role in the pathophysiology of NASH through induction of secreted factors that trigger inflammation and hepatocellular death via a signaling pathway specific to human hepatocytes
Multifocal Gastric Ulcers Caused by Diffuse Large B Cell Lymphoma in a Patient With Significant Weight Loss
Primary gastrointestinal (GI) lymphoma is a heterogeneous disease with varied clinical presentations. The stomach is the most common GI site and accounts for 70% to 75% of GI lymphomas. We present a patient with gastric diffuse large B cell lymphoma (DLBCL) who presented with significant weight loss, early satiety, and multifocal ulcerated gastric lesions. Esophagoduodenoscopy should be performed in patients presenting with warning symptoms as in our case. Diagnosis is usually made by endoscopic biopsies. Multiple treatment modalities including surgery, radiotherapy, and chemotherapy have been used. Advancements in endoscopic and pathologic technology decrease turnaround time for diagnosis and treatment initiation, thus reducing the need for surgery. Health care providers should maintain a high level of suspicion and consider gastric DLBCL as part of the differential diagnosis, especially in those with warning symptoms such as weight loss and early satiety with abnormal endoscopic findings
Twisting algebras using non-commutative torsors
Non-commutative torsors (equivalently, two-cocycles) for a Hopf algebra can
be used to twist comodule algebras. After surveying and extending the
literature on the subject, we prove a theorem that affords a presentation by
generators and relations for the algebras obtained by such twisting. We give a
number of examples, including new constructions of the quantum affine spaces
and the quantum tori.Comment: 27 pages. Masuoka is a new coauthor. Introduction was revised.
Sections 1 and 2 were thoroughly restructured. The presentation theorem in
Section 3 is now put in a more general framework and has a more general
formulation. Section 4 was shortened. All examples (quantum affine spaces and
tori, twisting of SL(2), twisting of the enveloping algebra of sl(2)) are
left unchange
375: The Analysis of Chronic GVHD after Cord Blood Transplantation in Comparison with Bone Marrow Transplantation
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