Circular strategies for building sector decarbonization in China: A scenario analysis

The building sector in China is responsible for 40% of total energy-related CO2 emissions, driven by its large population, continuous economic growth, and construction boom. In addition to greenhouse gas (GHG) emissions from energy use, buildings drive significant emissions for construction activities and production of energy-intensive materials, such as steel and cement. While supply-side energy strategies have been extensively explored, a demand-side perspective that considers stock dynamics and circularity improvements is essential to assess sustainable pathways for the buildings sector. Here, we explore a set of decarbonization scenarios for the building sector in China considering a range of circular strategies and their interplay with different climate policies. The strategies include lifetime extension of buildings, switch to wood-based construction, reduction of per-capita floorspace, and a combination of all three strategies. We use the building sector model MESSAGEix-Buildings soft linked to the integrated assessment model (IAM) MESSAGEix-GLOBIOM and prospective life cycle assessment (LCA) to assess the effects of these circular strategies on building material and energy demands, and operational and embodied emissions. We find that the three strategies could reduce building material demand up to 60% on mass basis by 2060 compared to a reference scenario with continuation of current policies. This translates into a reduction of embodied and total GHG emissions of 62% and 24%, respectively, significantly contributing to achieving decarbonization targets. Integrating industrial ecology methods in IAMs, as demonstrated in this study, can provide valuable insights to inform national policy decisions on mitigation strategies accounting for both demand and supply sides

TOPICAL REVIEW: Microfluidics for flow cytometric analysis of cells and particles

This review describes recent developments in microfabricated flow cytometers and related microfluidic devices that can detect, analyze, and sort cells or particles. The high-speed analytical capabilities of flow cytometry depend on the cooperative use of microfluidics, optics and electronics. Along with the improvement of other components, replacement of conventional glass capillary-based fluidics with microfluidic sample handling systems operating in microfabricated structures enables volume- and power-efficient, inexpensive and flexible analysis of particulate samples. In this review, we present various efforts that take advantage of novel microscale flow phenomena and microfabrication techniques to build microfluidic cell analysis systems.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49182/2/pm5_3_r02.pd

Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells.

Dendritic cell (DC) vaccination, albeit still in an early stage, is a promising strategy to induce immunity to cancer. We explored whether DC can expand Ag-specific CD8+ T cells even in far-advanced stage IV melanoma patients. We found that three to five biweekly vaccinations of mature, monocyte-derived DC (three vaccinations of 6 x 106 s.c. followed by two i.v. ones of 6 and 12 x 106, respectively) pulsed with Mage-3A2.1 tumor and influenza matrix A2. 1-positive control peptides as well as the recall Ag tetanus toxoid (in three of eight patients) generated in all eight patients Ag-specific effector CD8+ T cells that were detectable in blood directly ex vivo. This is the first time that active, melanoma peptide-specific, IFN-gamma-producing, effector CD8+ T cells have been reliably observed in patients vaccinated with melanoma Ags. Therefore, our DC vaccination strategy performs an adjuvant role and encourages further optimization of this new immunization approach