Multifrequency Aperture-Synthesizing Microwave Radiometer System (MFASMR). Volume 2: Appendix

A number of topics supporting the systems analysis of a multifrequency aperture-synthesizing microwave radiometer system are discussed. Fellgett's (multiple) advantage, interferometer mapping behavior, mapping geometry, image processing programs, and sampling errors are among the topics discussed. A FORTRAN program code is given

Multifrequency Aperture-Synthesizing Microwave Radiometer System (MFASMR). Volume 1

Background material and a systems analysis of a multifrequency aperture - synthesizing microwave radiometer system is presented. It was found that the system does not exhibit high performance because much of the available thermal power is not used in the construction of the image and because the image that can be formed has a resolution of only ten lines. An analysis of image reconstruction is given. The system is compared with conventional aperture synthesis systems

Astronomy in the Cloud: Using MapReduce for Image Coaddition

In the coming decade, astronomical surveys of the sky will generate tens of terabytes of images and detect hundreds of millions of sources every night. The study of these sources will involve computation challenges such as anomaly detection and classification, and moving object tracking. Since such studies benefit from the highest quality data, methods such as image coaddition (stacking) will be a critical preprocessing step prior to scientific investigation. With a requirement that these images be analyzed on a nightly basis to identify moving sources or transient objects, these data streams present many computational challenges. Given the quantity of data involved, the computational load of these problems can only be addressed by distributing the workload over a large number of nodes. However, the high data throughput demanded by these applications may present scalability challenges for certain storage architectures. One scalable data-processing method that has emerged in recent years is MapReduce, and in this paper we focus on its popular open-source implementation called Hadoop. In the Hadoop framework, the data is partitioned among storage attached directly to worker nodes, and the processing workload is scheduled in parallel on the nodes that contain the required input data. A further motivation for using Hadoop is that it allows us to exploit cloud computing resources, e.g., Amazon's EC2. We report on our experience implementing a scalable image-processing pipeline for the SDSS imaging database using Hadoop. This multi-terabyte imaging dataset provides a good testbed for algorithm development since its scope and structure approximate future surveys. First, we describe MapReduce and how we adapted image coaddition to the MapReduce framework. Then we describe a number of optimizations to our basic approach and report experimental results comparing their performance.Comment: 31 pages, 11 figures, 2 table

Towards a Process Domain‐Sensitive Substrate Habitat Model for Sea Lampreys in Michigan Rivers

Habitat mapping is a common and often useful tool in the ecological management of rivers. The complex nature of fluvial processes, however, makes it difficult to predict the reach‐scale distribution of substrate habitat from landscape‐scale covariates. An option is to identify and partition a data set on boundaries of geomorphic process domains, within which the globally complex relationships between landscape, climate, and instream habitat may potentially be approximated by a simpler model. In this study, we used regression trees as a machine learning method for partitioning and identifying useful strata in a geographically extensive substrate habitat model for larvae of the sea lamprey Petromyzon marinus, an invasive and economically harmful species in the Laurentian Great Lakes. We used field survey data from over 5,000 substrate habitat transects collected in 43 watersheds of the Lower Peninsula of Michigan, and we created a geographic database of geographical information systems‐derived covariates that represent the principal geomorphic influences on substrate habitat. We created three trees in which tree splits delineated (1) spatially contiguous units, (2) noncontiguous units defined by values of the covariates, and (3) both contiguous and noncontiguous units. The adjusted R2 values of the three trees were 0.30, 0.30, and 0.32, respectively, and all three trees outperformed a single model fitted to the entire data set and a set of models fitted to each watershed individually. The trees identified useful stratifications of Michigan’s Lower Peninsula, important geomorphic influences on substrate habitat, and variation in the influence of geomorphic processes on substrate habitat across our study region. Conservation and management applications of our model predictions and tree‐based stratifications include sea lamprey population modeling, habitat survey design, and evaluation of dam removal.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141668/1/tafs0313.pd

DataQ: A Collaborative Platform for Answering Research Data Questions in Libraries

DataQ is an IMLS­-funded project led by the University of Colorado Boulder Libraries, GWLA, and GPN to develop an online knowledge-­base of research data questions and answers curated for and by the library community. Publicly submitted questions to DataQ are reviewed by an Editorial Team of experts from 15 institutions across the United States. The site also includes links to resources, best practices, and practical approaches to working with researchers to address specific research data issues. This update from members of the Editorial Team will discuss outcomes and future directions following the first year of the DataQ project

Opportunities to encourage mail order pharmacy delivery service use for diabetes prescriptions: a qualitative study.

BackgroundMedication non-adherence is a major contributor to poor outcomes in diabetes. Previous research has shown an association between use of mail order pharmacy delivery and better medication adherence, but little is known about the barriers and facilitators to mail order pharmacy use in diabetes patients. This qualitative study examined factors related to mail order pharmacy use versus traditional "brick and mortar" pharmacies to refill prescriptions.MethodsWe conducted four 90-min focus groups in 2016 among 28 diabetes patients in the Hawaii and Northern California regions of Kaiser Permanente, a large integrated health care delivery system. We queried participants on their preferred mode for refilling prescriptions and perceived barriers and facilitators of mail order pharmacy use. One researcher independently coded each focus group transcript, with two of these transcripts double-coded by a second researcher to promote reliability. We employed thematic analysis guided by the Capability, Opportunity, Motivation, and Behavior (COM-B) framework using NVivo 11 software.ResultsA total of 28 diabetes patients participated. Participants' average age was 64.1 years; 57% were female; and racial/ethnic backgrounds included Asian/Native Hawaiian/Pacific Islander (36%), Black/African-American (21%) Hispanic/Latino (7%), and non-Hispanic White (36%). Analysis uncovered 26 themes related to the decision to use mail order pharmacy, with each theme representing a barrier or facilitator mapped to the COM-B framework. Most themes (20/26) fell into the COM-B category of 'Opportunity.' Opportunity barriers to mail order pharmacy use included unpredictability of medication delivery date, concerns about mail security, and difficulty coordinating refill orders for multiple prescriptions. In contrast, facilitators included greater access and convenience (e.g., no need to wait in line or arrange transportation) compared to traditional pharmacies. Motivational facilitators to mail order pharmacy use included receiving a pharmacy benefit plan incentive of a free one-month supply of prescriptions.ConclusionsThis study found that while patients with diabetes may benefit from mail order pharmacy use, they perceive numerous barriers to using the service. These findings will inform the design of interventions and quality improvement initiatives to increase mail order pharmacy use, which in turn may improve medication adherence and outcomes in diabetes patients, across health care systems

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena

<p>Abstract</p> <p>Background</p> <p>The NAD⁺-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity in development, aging, and disease; yet, underlying mechanistic pathways are not well understood. Specific sirtuins influence chromatin structure and gene expression, but differences in their pathways as they relate to distinct chromatin functions are just beginning to emerge. To further define the range of global chromatin changes dependent on sirtuins, unique biological features of the ciliated protozoan <it>Tetrahymena thermophila </it>can be exploited. This system offers clear spatial and temporal separation of multiple whole genome restructuring events critical for the life cycle.</p> <p>Results</p> <p>Inhibition with nicotinamide revealed that sirtuin deacetylase activity in <it>Tetrahymena </it>cells promotes chromatin condensation during meiotic prophase, differentiation of heterochromatin from euchromatin during development, and chromatin condensation/degradation during programmed nuclear death. We identified a class I sirtuin, called Thd14, that resides in mitochondria and nucleoli during vegetative growth, and forms a large sub-nuclear aggregate in response to prolonged cell starvation that may be peripherally associated with nucleoli. During sexual conjugation and development Thd14 selectively concentrates in the parental nucleus prior to its apoptotic-like degradation.</p> <p>Conclusions</p> <p>Sirtuin activity is important for several functionally distinct events requiring global chromatin condensation. Our findings suggest a novel role for sirtuins in promoting programmed pycnosis by acting on chromatin destined for degradation. The sirtuin Thd14, which displays physiological-dependent differential localization within the nucleus, is a candidate for a chromatin condensation enzyme that is coupled to nuclear degradation.</p

The two stories of the habitus/structure relation and the riddle of reflexivity: A meta‐theoretical reappraisal

This article argues that two key puzzles arising from the theories of Bourdieu are inter-related. One is the question of how Bourdieu analyses the relationship between structure and habitus, and the other is the place of reflexivity in Bourdieu's work. We contend that it is only by carefully analysing Bourdieu's theoretical structure to grasp the relationship between these elements that one can understand whether or not his work offers useful resources for analysing the relation between routine action and self-reflection. This paper argues that there are two narrations of the structure/habitus relation in Bourdieu's work, and that the concept of self-reflective subjectivity is a residual element of the first narration and does not appear in the second. We then contend that this residual and under-developed concept of self-reflective subjectivity should not be confused with Bourdieu's analysis of epistemic reflexivity. These moves allow us to contribute to ongoing debates about the relation between routine action and self-reflection by arguing that the concept of the “reflexive habitus” – which some have argued is characteristic of social agents in high/late modernity – is both conceptually confused and is not a logical extension of Bourdieu's theories. In this way we try to clear the ground for more productive ways of thinking about routine action and self-reflection

Transient x-ray diffraction used to diagnose shock compressed Si crystals on the Nova laser

Transient x-ray diffraction is used to record time-resolved information about the shock compression of materials. This technique has been applied on Nova shock experiments driven using a hohlraum x-ray drive. Data were recorded from the shock release at the free surface of a Si crystal, as well as from Si at an embedded ablator/Si interface. Modeling has been done to simulate the diffraction data incorporating the strained crystal rocking curves and Bragg diffraction efficiencies. Examples of the data and post-processed simulations are presented

Ten myths about character, virtue and virtue education – plus three well-founded misgivings

Initiatives to cultivate character and virtue in moral education at school continue to provoke sceptical responses. Most of those echo familiar misgivings about the notions of character, virtue and education in virtue – as unclear, redundant, old-fashioned, religious, paternalistic, anti-democratic, conservative, individualistic, relative and situation dependent. I expose those misgivings as ‘myths’, while at the same time acknowledging three better-founded historical, methodological and practical concerns about the notions in question