40 research outputs found
CĂąncer e meio ambiente. Tabaco - agrotĂłxicos - radiaçÔes â dieta. Um documento para a ConferĂȘncia Mundial de Ecologia
Trabalho elaborado como parte de um documento global sobre SaĂșde e Meio Ambiente da Fundação Oswaldo Cruz
Global survival trends for brain tumors, by histology: analysis of individual records for 556,237 adults diagnosed in 59 countries during 2000â2014 (CONCORD-3)
Background:
Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology.
Methods:
We analyzed individual data for adults (15â99 years) diagnosed with a brain tumor (ICD-O-3 topography code C71) during 2000â2014, regardless of tumor behavior. Data underwent a 3-phase quality control as part of CONCORD-3. We estimated net survival for 11 histology groups, using the unbiased nonparametric Pohar Perme estimator.
Results:
The study included 556,237 adults. In 2010â2014, the global range in age-standardized 5-year net survival for the most common sub-types was broad: in the range 20%â38% for diffuse and anaplastic astrocytoma, from 4% to 17% for glioblastoma, and between 32% and 69% for oligodendroglioma. For patients with glioblastoma, the largest gains in survival occurred between 2000â2004 and 2005â2009. These improvements were more noticeable among adults diagnosed aged 40â70 years than among younger adults.
Conclusions:
To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors by histology in adults. We have highlighted remarkable gains in 5-year survival from glioblastoma since 2005, providing large-scale empirical evidence on the uptake of chemoradiation at population level. Worldwide, survival improvements have been extensive, but some countries still lag behind. Our findings may help clinicians involved in national and international tumor pathway boards to promote initiatives aimed at more extensive implementation of clinical guidelines
Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000â14 (CONCORD-3) : analysis of individual data from 258 cancer registries in 61 countries
Background Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed
data for children (aged 0â14 years) and adults (aged 15â99 years) diagnosed with a haematological malignancy
during 2000â14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and
morphology, in young patients (aged 0â24 years).
Methods We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3
that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0â14 years),
adolescents (15â19 years), and young adults (20â24 years). We categorised leukaemia subtypes according to the
International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases
for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs,
using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by
country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age
survival estimates were standardised to the marginal distribution of young people with leukaemia included in the
analysis.
Findings 164563 young people were included in this analysis: 121328 (73·7%) children, 22963 (14·0%) adolescents, and
20272 (12·3%) young adults. In 2010â14, the most common subtypes were lymphoid leukaemia (28205 [68·2%] patients)
and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and
young adults for all leukaemias combined during 2010â14 varied widely, ranging from 46% in Mexico to more than
85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better
age-standardised survival (from 43% in Ecuador to â„80% in parts of Europe, North America, Oceania, and Asia) than
those with acute myeloid leukaemia (from 32% in Peru to â„70% in most high-income countries in Europe,
North America, and Oceania). Throughout 2000â14, survival from all leukaemias combined remained consistently
higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young
adults in most countries.
Interpretation This study offers the first worldwide picture of population-based survival from leukaemia in children,
adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower
survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators
of the quality of cancer management in this age group.peer-reviewe
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability
Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) â500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications
AlteraçÔes genĂ©ticas no cancro do pulmĂŁo: Avaliação das limitaçÔes ao seu uso na rotina clĂnica Genetic alterations in lung cancer: Assessing limitations in routine clinical use
O cancro do pulmĂŁo Ă© a causa mais frequente de mortalidade por cancro no mundo, sendo responsĂĄvel por cerca de 1,1 milhĂ”es de mortes por ano. A sobrevivĂȘncia mĂ©dia dos doentes Ă© geralmente curta, por a doença se encontrar em estĂĄdios avançados na altura do diagnĂłstico, mas tambĂ©m devido Ă falta de eficĂĄcia dos tratamentos disponĂveis. O advento da genĂ©tica molecular dos tumores trouxe consigo a possibilidade de modificar esta situação, quer atravĂ©s do refinamento do diagnĂłstico, quer da identificação de alvos terapĂȘuticos especĂficos, quer sobretudo por - pelo menos em teoria - permitir o diagnĂłstico precoce da doença. No entanto, e apesar de numerosos trabalhos terem jĂĄ demonstrado a utilidade das tĂ©cnicas da genĂ©tica molecular no estudo do cancro do pulmĂŁo, o seu uso na rotina clĂnica em Portugal tem sido limitado. No presente estudo, utilizou-se a pesquisa de mutaçÔes no anti-oncogene p53 em amostras clĂnicas de doentes com diagnĂłstico de cancro do pulmĂŁo como mĂ©todo para identificar as dificuldades prĂĄticas Ă integração da genĂ©tica molecular na rotina clĂnica. Os resultados obtidos sugerem que o principal factor limitante a essa integração Ă© a obtenção de amostras de ADN de qualidade, um problema que pode ser superado pela alteração das prĂĄticas correntes de recolha de amostras.Lung cancer is the most frequent cause of cancer mortality worldwide, responsible for approximately 1.1 million deaths per year. Median survival is short, both as most tumours are diagnosed at an advanced stage and because of the limited efficacy of available treatments. The development of tumour molecular genetics carries the promise of altering this state of affairs, as it should lead to a more precise classification of tumours, identify specific molecular targets for therapy and, above all, allow the development of new methods for early diagnosis. Despite numerous studies demonstrating the usefulness of molecular genetic techniques in the study of lung cancer, its routine clinical use in Portugal has, however, been limited. In this study, we used a p53 mutation screen in multiple clinical samples from a series of lung cancer patients to attempt to identify the main practical limitations to the integration of molecular genetics in routine clinical practice. Our results suggest that the main limiting factor is the availability of samples with good quality DNA; a problem that could be overcome by alterations in common sample collection and storage procedures
ColĂŽnia agrĂcola amazĂŽnica sob inquĂ©rito mĂ©dico-social I â Sintomatologia digestiva ligada ao enteroparasitismo e Ă carĂȘncia (Publicado originalmente em 1967)
MinistĂ©rio da SaĂșde. Fundação Serviço Especial de SaĂșde PĂșblica. Instituto Evandro Chagas. BelĂ©m, PA, Brasil / Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Instituto de Desenvolvimento EconĂŽmico e Social do ParĂĄ. BelĂ©m, PA, Brasil.Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Universidade Federal do ParĂĄ. Faculdade de Medicina. BelĂ©m, PA. Brasil.Equipe das cĂĄtedras de ClĂnica MĂ©dica e de Parasitologia,
da Faculdade de Medicina da Universidade Federal do ParĂĄ, que, em
janeiro de 1965, se dirigiu ao interior do municĂpio de Nova Timboteua,
na zona bragantina, em estudos de natureza médico-social, achou
interessante estender suas observaçÔes Ă colĂŽnia agrĂcola de SumaĂșma,
que pode ser tomada como tĂpica dessa zona fisiogrĂĄfica paraense.
Ă que a dispersĂŁo das moradias, sem casas geminadas e,
atĂ©, sem arruamento, com casas desocupadas por perĂodos de safras,
quando os moradores se deslocam em busca de terras de melhor
rendimento para determinados cultivos, oferece oportunidade de
comparação de dados com os de aglomerado de povoação situada Ă
distĂąncia de alguns quilĂŽmetros.
A repercussĂŁo do enteroparasitismo e da carĂȘncia na
sintomatologia digestiva foi detectada em entrevistas individuais com 35 moradores, de idades que garantissem maior fidelidade às informaçÔes,
consoante o quadro a seguir, dentre as 120 pessoas em que ficou estimada
a população global da colÎnia:
Pessoas
De 13 anos de idade 1
De 15 e 16 anos 3
De 20 a 40 anos 21
De mais de 40 anos 10
Total 35
Os dados, coligidos em percentuais, falam a favor de
condiçÔes nutricionais nĂŁo satisfatĂłrias, presentes distĂșrbios digestivos
na vigĂȘncia de parasitismo intestinal