Three--body Correlation Effects on the Spin Dynamics of Double--Exchange Ferromagnets

We present a variational calculation of the spin wave excitation spectrum of double--exchange ferromagnets in different dimensions. Our theory recovers the Random Phase approximation and 1/S expansion results as limiting cases and can be used to study the intermediate exchange coupling and electron concentration regime relevant to the manganites. In particular, we treat exactly the long range three--body correlations between a Fermi sea electron--hole pair and a magnon excitation and show that they strongly affect the spin dynamics in the parameter range relevant to experiments in the manganites. The manifestations of these correlations are many-fold. We demonstrate that they significantly change the ferromagnetic phase boundary. In addition to a decrease in the magnon stiffness, we obtain an instability of the ferromagnetic state against spin wave excitations close to the Brillouin zone boundary.Within a range of intermediate concentrations, we find a strong softening of the spin wave dispersion as compared to the Heisenberg ferromagnet with the same stiffness, which changes into hardening for other concentrations. We discuss the relevance of these results to experiments in colossal magnetoresistance ferromagnets.Comment: 14 pages, 11 figures, published in Phys. Rev. B (1 figure added, references added

Predicting fraud in mobile money transfer using case-based reasoning

This paper proposes an improved CBR approach for the identification of money transfer fraud in Mobile Money Transfer (MMT) environments. Standard CBR capability is augmented by machine learning techniques to assign parameter weights in the sample dataset and automate k-value random selection in k-NN classification to improve CBR performance. The CBR system observes users’ transaction behaviour within the MMT service and tries to detect abnormal patterns in the transaction flows. To capture user behaviour effectively, the CBR system classifies the log information into five contexts and then combines them into a single dimension, instead of using the conventional approach where the transaction amount, time dimensions or features dimension are used individually. The applicability of the proposed augmented CBR system is evaluated using simulation data. From the results, both dimensions show good performance with the context of information weighted CBR system outperforming the individual features approach

Improved movie recommendations based on a hybrid feature combination method

Recommender systems help users find relevant items efficiently based on their interests and historical interactions with other users. They are beneficial to businesses by promoting the sale of products and to user by reducing the search burden. Recommender systems can be developed by employing different approaches, including collaborative filtering (CF), demographic filtering (DF), content-based filtering (CBF) and knowledge-based filtering (KBF). However, large amounts of data can produce recommendations that are limited in accuracy because of diversity and sparsity issues. In this paper, we propose a novel hybrid method that combines user–user CF with the attributes of DF to indicate the nearest users, and compare four classifiers against each other. This method has been developed through an investigation of ways to reduce the errors in rating predictions based on users’ past interactions, which leads to improved prediction accuracy in all four classification algorithms. We applied a feature combination method that improves the prediction accuracy and to test our approach, we ran an offline evaluation using the 1M MovieLens dataset, well-known evaluation metrics and comparisons between methods with the results validating our proposed method

Is BMI alone a sufficient outcome to evaluate interventions for child obesity?

BACKGROUND: BMI is often used to evaluate the effectiveness of childhood obesity interventions, but such interventions may have additional benefits independent of effects on adiposity. We investigated whether benefits to health outcomes following the Mind, Exercise, Nutrition…Do It! (MEND) childhood obesity intervention were independent of or associated with changes in zBMI. METHODS: A total of 79 obese children were measured at baseline; 71 and 42 participants were followed-up at 6 and 12 months respectively, and split into four groups depending on magnitude of change in zBMI. Differences between groups for waist circumference, cardiovascular fitness, physical and sedentary activities, and self-esteem were investigated. RESULTS: Apart from waist circumference and its z-score, there were no differences or trends across zBMI subgroups for any outcome. Independent of the degree of zBMI change, benefits in several parameters were observed in children participating in this obesity intervention. CONCLUSION: We concluded that isolating a single parameter like zBMI change and neglecting other important outcomes is restrictive and may undermine the evaluation of childhood obesity intervention effectiveness

Assessment-schedule matching in unanchored indirect treatment comparisons of progression-free survival in cancer studies

Background The timing of efficacy-related clinical events recorded at scheduled study visits in clinical trials are interval censored, with the interval duration pre-determined by the study protocol. Events may happen any time during that interval but can only be detected during a planned or unplanned visit. Disease progression in oncology is a notable example where the time to an event is affected by the schedule of visits within a study. This can become a source of bias when studies with varying assessment schedules are used in unanchored comparisons using methods such as matching-adjusted indirect comparisons. Objective We illustrate assessment-time bias (ATB) in a simulation study based on data from a recent study in second-line treatment for locally advanced or metastatic urothelial carcinoma, and present a method to adjust for differences in assessment schedule when comparing progression-free survival (PFS) against a competing treatment. Methods A multi-state model for death and progression was used to generate simulated death and progression times, from which PFS times were derived. PFS data were also generated for a hypothetical comparator treatment by applying a constant hazard ratio (HR) to the baseline treatment. Simulated PFS times for the two treatments were then aligned to different assessment schedules so that progression events were only observed at set visit times, and the data were analysed to assess the bias and standard error of estimates of HRs between two treatments with and without assessment-schedule matching (ASM). Results ATB is highly affected by the rate of the event at the first assessment time; in our examples, the bias ranged from 3 to 11% as the event rate increased. The proposed method relies on individual-level data from a study and attempts to adjust the timing of progression events to the comparator’s schedule by shifting them forward or backward without altering the patients’ actual follow-up time. The method removed the bias almost completely in all scenarios without affecting the precision of estimates of comparative effectiveness. Conclusions Considering the increasing use of unanchored comparative analyses for novel cancer treatments based on single-arm studies, the proposed method offers a relatively simple means of improving the accuracy of relative benefits of treatments on progression times

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial

Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit. We assessed whether the addition of xenon gas, a promising novel therapy, after the initiation of hypothermia for birth asphyxia would result in further improvement. Methods Total Body hypothermia plus Xenon (TOBY-Xe) was a proof-of-concept, randomised, open-label, parallel-group trial done at four intensive-care neonatal units in the UK. Eligible infants were 36–43 weeks of gestational age, had signs of moderate to severe encephalopathy and moderately or severely abnormal background activity for at least 30 min or seizures as shown by amplitude-integrated EEG (aEEG), and had one of the following: Apgar score of 5 or less 10 min after birth, continued need for resuscitation 10 min after birth, or acidosis within 1 h of birth. Participants were allocated in a 1:1 ratio by use of a secure web-based computer-generated randomisation sequence within 12 h of birth to cooling to a rectal temperature of 33·5°C for 72 h (standard treatment) or to cooling in combination with 30% inhaled xenon for 24 h started immediately after randomisation. The primary outcomes were reduction in lactate to N-acetyl aspartate ratio in the thalamus and in preserved fractional anisotropy in the posterior limb of the internal capsule, measured with magnetic resonance spectroscopy and MRI, respectively, within 15 days of birth. The investigator assessing these outcomes was masked to allocation. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00934700, and with ISRCTN, as ISRCTN08886155. Findings The study was done from Jan 31, 2012, to Sept 30, 2014. We enrolled 92 infants, 46 of whom were randomly assigned to cooling only and 46 to xenon plus cooling. 37 infants in the cooling only group and 41 in the cooling plus xenon group underwent magnetic resonance assessments and were included in the analysis of the primary outcomes. We noted no significant differences in lactate to N-acetyl aspartate ratio in the thalamus (geometric mean ratio 1·09, 95% CI 0·90 to 1·32) or fractional anisotropy (mean difference −0·01, 95% CI −0·03 to 0·02) in the posterior limb of the internal capsule between the two groups. Nine infants died in the cooling group and 11 in the xenon group. Two adverse events were reported in the xenon group: subcutaneous fat necrosis and transient desaturation during the MRI. No serious adverse events were recorded. Interpretation Administration of xenon within the delayed timeframe used in this trial is feasible and apparently safe, but is unlikely to enhance the neuroprotective effect of cooling after birth asphyxia

On the Cosmology of Massive Vector Fields with SO(3) Global Symmetry

A relevant reference ([14]) has been added.Comment: 19 pages, plain tex, DF/IST-3/92 and DFFCUL 03-5/199

Bundles over Nearly-Kahler Homogeneous Spaces in Heterotic String Theory

We construct heterotic vacua based on six-dimensional nearly-Kahler homogeneous manifolds and non-trivial vector bundles thereon. Our examples are based on three specific group coset spaces. It is shown how to construct line bundles over these spaces, compute their properties and build up vector bundles consistent with supersymmetry and anomaly cancelation. It turns out that the most interesting coset is $SU(3)/U(1)^2$. This space supports a large number of vector bundles which lead to consistent heterotic vacua, some of them with three chiral families.Comment: 32 pages, reference adde

Coset Space Dimensional Reduction and Wilson Flux Breaking of Ten-Dimensional N=1, E(8) Gauge Theory

We consider a N=1 supersymmetric E(8) gauge theory, defined in ten dimensions and we determine all four-dimensional gauge theories resulting from the generalized dimensional reduction a la Forgacs-Manton over coset spaces, followed by a subsequent application of the Wilson flux spontaneous symmetry breaking mechanism. Our investigation is constrained only by the requirements that (i) the dimensional reduction leads to the potentially phenomenologically interesting, anomaly free, four-dimensional E(6), SO(10) and SU(5) GUTs and (ii) the Wilson flux mechanism makes use only of the freely acting discrete symmetries of all possible six-dimensional coset spaces.Comment: 45 pages, 2 figures, 10 tables, uses xy.sty, longtable.sty, ltxtable.sty, (a shorter version will be published in Eur. Phys. J. C

Lorentz Invariance and the Cosmological Constant

Non-trivial solutions in string field theory may lead to the spontaneous breaking of Lorentz invariance and to new tensor-matter interactions. It is argued that requiring the contribution of the vacuum expectation values of Lorentz tensors to account for the vacuum energy up to the level that $\Omega_{0}^{\Lambda} = 0.5$ implies the new interactions range is $\lambda \sim 10^{-4} m$. These conjectured violations of the Lorentz symmetry are consistent with the most stringent experimental limits.Comment: 13 pages, plain Latex. This essay was selected for an honorable mention in the 1997 Gravity Research Foundation essay competio