William M. Leigh

William Leigh was born in Bulloch County Georgia about December 29 1804 . He was a merchant by trade dealing in wood and groceries with his partner Jonah Bird. Little is known of his life before the early 1830\u27s. He married Sarah Shipman of New Jersey . March 2 1831. They were married by Stephen A. Mealy pastor of the Lutheran Church. There were three girls born of this marriage. Amanda Malvina was born in 1832 and died November 7, 1833 of Croup and Sore Throat. Mary A. was born December 1833 and Sarah J. in 1835. His wife Sarah died October 7, 1835 of Child Bed leaving Mr. Leigh with the two girls, one just an in­fant. Amanda and Sarah are buried at Laural Grove Cemetery. Sarah Leigh was 30 years old at the time of her deathhttps://digitalcommons.georgiasouthern.edu/sav-bios-lane/1210/thumbnail.jp

Collective corporate social responsibility:The role of trust as an organizing principle

Organizing corporate social responsibility (CSR) on a collective, rather than on the individual firm level, results in a set of specific challenges for organizations. The aim of this article is to assess these challenges inherent in collective CSR and to conceptualize trust as an organizing principle within these networks. To do so, we explore and outline the chief challenges faced within horizontal cooperation between inter-organizational actors aiming to realize CSR efforts collectively. Subsequently, we draw from the literature on trust as an organizing principle in inter-organizational networks and go on to develop mechanisms through which trust can address these challenges. This article contributes a new analytical framework that informs future studies on the role of trust in collective CSR. It enables a differentiated analysis of the potential, but also the pitfalls, of trust-based CSR at the network level

Managing competing demands:Coping with the inclusiveness–efficiency paradox in cross-sector partnerships

This article discusses how cross-sector partnerships (CSPs) for sustainability manage the paradoxical tension between stakeholder inclusiveness and administrative efficiency. Drawing on qualitative data from a case study of a CSP focused on urban sustainability, we show how the inclusiveness–efficiency paradox unfolded throughout the studied collaboration. We discuss how the paradox reemerged in a different guise within each phase of the partnership and how three practices of paradox management helped actors to cope with the tension: “customized inviting” (during the formation phase), “sequential including” (during the preparation phase), and “tailored instructing” (during the implementation phase). On the basis of these findings, we argue that (a) the paradox reoccurred throughout the phases of the CSP because the three paradox management practices accentuated boundaries, thereby helping to resolve the paradox temporarily while at the same time creating grounds for the paradox to resurface, and (b) that the three paradox management practices can be theorized as a special type of boundary work that “plays up” relevant differences between actor groups and thereby ensures collaboration

Morphological and Chemical Properties of Plastic Residues in Composts

The relative quantity of plastic film residues and other man-made materials in composts prepared from municipal solid wastes (MSW), biosolids, yard wastes, and pine bark was evaluated utilizing light and scanning electron microscopy equipped with energy dispersive X-ray analyzer. MSW composts screened through a 4 mm screen contained significant but highly variable quantities of plastic film residues and other man-made materials that escaped detection with the unaided eye. The other composts were free of such particles. We conclude that the database for evaluation of man-made materials in MSW composts is inadequate and must be developed further

PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage healthy tissues. The initiation of BER by the alkyladenine DNA glycosylase (AAG, a.k.a. MPG) can mediate alkylation-induced cytotoxicity in specific cells in the retina and cerebellum of male mice. Cytotoxicity in both wild-type andAag-transgenic (AagTg) mice is abrogated in the absence of Poly(ADP-ribose) polymerase-1 (PARP1). Here, we tested whether PARP inhibitors can also prevent alkylation-induced retinal and cerebellar degeneration in male and female WT andAagTgmice. Importantly, we found that WT mice display sex-dependent alkylation-induced retinal damage (but not cerebellar damage), with WT males being more sensitive than females. Accordingly, estradiol treatment protects males against alkylation-induced retinal degeneration. InAagTgmale and female mice, the alkylation-induced tissue damage in both the retina and cerebellum is exacerbated and the sex difference in the retina is abolished. PARP inhibitors, much likeParp1gene deletion, protect against alkylation-induced AAG-dependent neuronal degeneration in WT andAagTgmice, regardless of the gender, but their efficacy in preventing alkylation-induced neuronal degeneration depends on PARP inhibitor characteristics and doses. The recent surge in the use of PARP inhibitors in combination with cancer chemotherapeutic alkylating agents might represent a powerful tool for obtaining increased therapeutic efficacy while avoiding the collateral effects of alkylating agents in healthy tissues.National Institutes of Health (U.S.) (Award R01- CA075576)National Institutes of Health (U.S.) (Award R01-CA055042)National Institutes of Health (U.S.) (Award P30-ES02109)National Institutes of Health (U.S.) (Award P30- CA014051

Microplastics in Namibian river sediments – a first evaluation

The African continent is rarely the focus of microplastics research, although the ubiquity of microplastics in the environment is undisputed and still increasing. Due to the high production and use of plastic products and the partial lack of recycling systems in many parts of the African continent, it can be assumed that microplastic particles are already present in limnic and terrestrial ecosystems. Few studies, mainly from South Africa and the Northern African region, show a contamination with microplastics, especially in marine environments. This study aims to explore the presence and composition of microplastics in fluvial sediments of the major catchments in Namibia with a regional focus on the Iishana system in Northern Namibia, as one of the most densely populated areas in the country. In March 2019 and March 2021, at the end of the rainy seasons, sediments from the Iishana system and of the largest river catchments were sampled. Extraction was performed by density separation using the Microplastic Sediment Separator (MPSS) with the separation solution sodium chloride (density of 1.20 g/cm3). The particle size was determined by filtration and fractionation, and the polymer type by measurement with ATR-FTIR spectroscopy (minimum particle size 0.3 mm). Microplastics were found in the sediments of each river system, most of the particles in the Iishana system (average of 13.2 particles/kg dry weight). The perennial, the ephemeral rivers, and the Iishana system are similar concerning polymer type and particle size. Polyethylene and polypropylene were the dominant polymer types. Most of the particles were found in the size fractions 0.3 – 0.5 mm and 0.5 – 1.0 mm. The particles were found mainly as fragments and films, the majority transparent and brown

Repair of endogenous DNA base lesions modulate lifespan in mice

The accumulation of DNA damage is thought to contribute to the physiological decay associated with the aging process. Here, we report the results of a large-scale study examining longevity in various mouse models defective in the repair of DNA alkylation damage, or defective in the DNA damage response. We find that the repair of spontaneous DNA damage by alkyladenine DNA glycosylase (Aag/Mpg)-initiated base excision repair and O[superscript 6]-methylguanine DNA methyltransferase (Mgmt)-mediated direct reversal contributes to maximum life span in the laboratory mouse. We also uncovered important genetic interactions between Aag, which excises a wide variety of damaged DNA bases, and the DNA damage sensor and signaling protein, Atm. We show that Atm plays a role in mediating survival in the face of both spontaneous and induced DNA damage, and that Aag deficiency not only promotes overall survival, but also alters the tumor spectrum in Atm[superscript −/−] mice. Further, the reversal of spontaneous alkylation damage by Mgmt interacts with the DNA mismatch repair pathway to modulate survival and tumor spectrum. Since these aging studies were performed without treatment with DNA damaging agents, our results indicate that the DNA damage that is generated endogenously accumulates with age, and that DNA alkylation repair proteins play a role in influencing longevity.National Institutes of Health (U.S.) (Grant R01-CA075576)National Institutes of Health (U.S.) (Grant R01-ES022872)National Institutes of Health (U.S.) (Grant R01-CA149261)National Institutes of Health (U.S.) (Grant P30-ES002109