Mori Dream Spaces

This article is based on the 7th Takagi Lectures that the author delivered at the University of Tokyo on November 21-23, 2009.We explore the circle of ideas connecting finite generation of the Cox ring, Mori dream spaces and invariant theory

The UA9 experimental layout

The UA9 experimental equipment was installed in the CERN-SPS in March '09 with the aim of investigating crystal assisted collimation in coasting mode. Its basic layout comprises silicon bent crystals acting as primary collimators mounted inside two vacuum vessels. A movable 60 cm long block of tungsten located downstream at about 90 degrees phase advance intercepts the deflected beam. Scintillators, Gas Electron Multiplier chambers and other beam loss monitors measure nuclear loss rates induced by the interaction of the beam halo in the crystal. Roman pots are installed in the path of the deflected particles and are equipped with a Medipix detector to reconstruct the transverse distribution of the impinging beam. Finally UA9 takes advantage of an LHC-collimator prototype installed close to the Roman pot to help in setting the beam conditions and to analyze the efficiency to deflect the beam. This paper describes in details the hardware installed to study the crystal collimation during 2010.Comment: 15pages, 11 figure, submitted to JINS

On base loci of higher fundamental forms of toric varieties

We study the base locus of the higher fundamental forms of a projective toric variety X at a general point. More precisely we consider the closure X of the image of a map (C*)k→Pn, sending t to the vector of Laurent monomials with exponents p0,…,pn∈Zk. We prove that the m-th fundamental form of such an X at a general point has non empty base locus if and only if the points pi lie on a suitable degree-m affine hypersurface. We then restrict to the case in which the points pi are all the lattice points of a lattice polytope and we give some applications of the above result. In particular we provide a classification for the second fundamental forms on toric surfaces, and we also give some new examples of weighted 3-dimensional projective spaces whose blowing up at a general point is not Mori dream

Four lectures on secant varieties

This paper is based on the first author's lectures at the 2012 University of Regina Workshop "Connections Between Algebra and Geometry". Its aim is to provide an introduction to the theory of higher secant varieties and their applications. Several references and solved exercises are also included.Comment: Lectures notes to appear in PROMS (Springer Proceedings in Mathematics & Statistics), Springer/Birkhause

Warm and Cold Magnetic and Mechanical Alignment Tests of LHC Short Straight Sections

This paper contains a summary of the results of the magnetic and mechanical alignment tests performed at CERN on the first 111 arc Short Straight Sections. These include the mechanical axis of the Cold Bore Tube at room temperature, the magnetic axis of main quadrupoles and correctors at both room and cryogenic temperature, and the field direction of the main quadrupoles. The measurements show that the quality of the assemblies is generally within the requirements for the machine

OPEN XAL Status Report 2015

MOPW1050International audienceOpen XAL is an accelerator physics software platformdeveloped in collaboration among several facilitiesaround the world. The Open XAL collaboration wasformed in 2010 to port, improve and extend the successfulXAL platform used at the Spallation Neutron Source foruse in the broader accelerator community and to establishit as the standard platform for accelerator physicssoftware. The site-independent core is complete, activeapplications have been ported, and now we are in theprocess of verification and transitioning to using OpenXAL in production. This paper will present the currentstatus and a roadmap for this project

Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease

Inflammatory cells are emerging markers in various cancers in human trials. The relationship between the inflammatory cells response, cancer grade, and progression has been investigated experimentally in a spontaneous canine model of breast cancer and in the unselected population (18–64 years.o.) under anti-HER2 treatments that represent the most prevalent population in this cancer type. The canine data (N samples = 101) were collected retrospectively for diagnosis in our regional area and evaluated by immunohistochemistry and haemato-chemistry. The inflammatory and immune-related adverse reactions (ADR) in humans were evaluated using EudraVigilance. The “Proportional Reporting Ratio” (PRR) of the mabs was calculated for each ADR with values >2 indicative of high risk. In dogs, we found elevated immunostaining of CD68-macrophages in the lymph node of the aggressive cancer G3 and infiltrating CD20+-lymphocyte. A high density of CD20 + lymphocytes was observed in G1 and a decrease in the density was observed with the histological degree of the tumors. The animals with the sample in G1 showed reduced serum platelet and neutrophil count and elevated lymphocytes and the opposite in severely affected animals. Inflammatory reactions with edema, skin reactions, extravasation, loss of effectiveness, and platelet count decrease (PRR > 13) were found with trastuzumab emtansine in humans, in the absence of immune system reactions. Trastuzumab i.v.-s.c. showed immune system reactions, loss of effectiveness, intolerances with drug withdrawal, technological issues (PRR > 7), and neutrophil count decrease reports. These reactions were less frequently reported for pertuzumab i.v. Case reports of platelet and neutrophil count decrease were not associated with disease progression with a better outcome in humans as in canine breast cancer. Therefore, infiltrating CD68-macrophages are associated with G3, while infiltrating CD20+ and elevated serum lymphocytes in parallel with reduced platelet and neutrophil count play a favorable role in human and canine breast cancer

The assessment and the within-plant variation of the morpho-physiological traits and VOCs profile in endemic and rare Salvia ceratophylloides Ard. (Lamiaceae)

Salvia ceratophylloides (Ard.) is an endemic and rare plant species recently rediscovered as very few individuals at two different Southern Italy sites. The study of within-plant variation is fundamental to understand the plant adaptation to the local conditions, especially in rare species, and consequently to preserve plant biodiversity. Here, we reported the variation of the morpho-ecophysiological and metabolic traits between the sessile and petiolate leaf of S. ceratophylloides plants at two different sites for understanding the adaptation strategies for surviving in these habitats. The S. ceratophylloides individuals exhibited different net photosynthetic rate, maximum quantum yield, light intensity for the saturation of the photosynthetic machinery, stomatal conductance, transpiration rate, leaf area, fractal dimension, and some volatile organic compounds (VOCs) between the different leaf types. This within-plant morpho-physiological and metabolic variation was dependent on the site. These results provide empirical evidence of sharply within-plant variation of the morpho-physiological traits and VOCs profiles in S. ceratophylloides, explaining the adaptation to the local conditions