47 research outputs found
Prerequisites for setting up management system in municipal retail trade
The relevance of the problem is determined by the number of complex problems that exist in present Samara municipal retail trade system, which is manifested in the lack of regulation, a glut of sales area, poorly developed infrastructure. The purpose of this article is to form a quantitative base for determining the municipal needs in the floor space. Leading method to study this problem is the method of empirical observations and mathematical modeling. The study results: the article contains the analysis of sales area availability on the example in the urban district and presents a quantitative method to determine predictive values for retail trade turnover. Practical significance: the paper is aimed to develop managerial decisions in the sphere of municipal trade regulation. Β© 2016 Suraeva et al
Discovering Class-Specific GAN Controls for Semantic Image Synthesis
Prior work has extensively studied the latent space structure of GANs forunconditional image synthesis, enabling global editing of generated images bythe unsupervised discovery of interpretable latent directions. However, thediscovery of latent directions for conditional GANs for semantic imagesynthesis (SIS) has remained unexplored. In this work, we specifically focus onaddressing this gap. We propose a novel optimization method for findingspatially disentangled class-specific directions in the latent space ofpretrained SIS models. We show that the latent directions found by our methodcan effectively control the local appearance of semantic classes, e.g.,changing their internal structure, texture or color independently from eachother. Visual inspection and quantitative evaluation of the discovered GANcontrols on various datasets demonstrate that our method discovers a diverseset of unique and semantically meaningful latent directions for class-specificedits.<br
Organizational model of the congress and exhibition cluster in the field of business travel
The relevance of the analyzed issue is caused by the growth of the international trade in the intensity of business travel services, including in the field of the congress and exhibition business, which necessitates the formation of the effective management model of business travel services at the destination level. The purpose of the article is to substantiate the formation algorithm of the cluster development strategy of tourism and the development of organizational functioning models of the congress and exhibition cluster in the destination. The leading approach to the study of this issue is the method of modeling, which allowed considering the practice of clusters functioning as a sequence of stages of its formation and development, taking into account the resource potential of destinations. Results: the article presents a stepwise algorithm for creating the congress and exhibition cluster in the destination and proves the fundamental organizational model for its functioning in the business tourism market; isolates and systematized criteria and indicators for assessing the contribution of participants of the tourism cluster in the destination development. The contents of this article may be useful for researchers, interested in the use of the cluster approach in the services sector, as well as to regional authorities, responsible for the development of tourism. Β© 2016 Karpova et al
ΠΠΎΠ½ΡΠ΅ΠΏΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Ρ ΠΊ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ²
From a conceptual position, historical development trends, current problems and prospects for ensuring the quality of personnel training were considered, taking into account the provisions of the organization management and quality management concepts. For the first time, conceptual approaches to ensuring the quality of personnel training were systematized and it was shown that they can be described by the following stages of development: in the 1900s, the concept of monitoring the quality of personnel training according to accepted standards; in the 1910s β the concept of taking into account the variability of the characteristics of the quality of training in the continuous process of learning; in the 1920s β a concept based on the large-scale use of statistical methods of quality control; in the 1930s β the concept of ensuring the reliability of knowledge and skills that guarantee the ability of trainees to keep them within the established limits at specified time intervals; in the 1940s. β a concept based on accounting in the system of personnel training for the best practical experience of previous periods of study; in the 1950s, the concept of active use in the management of training processes for quality tools; in the 1960s, with the concept of quality training, based on the TQC and CWQC quality management methodologies, taking into account the behavioral approach concept; in the 1970s, with the concept of quality training based on the TQM methodology; in the 1980s, using the concept of a management culture and the universal quality management system (UQM) as a basis; in the 1990s β the concept of quality management training, based on innovation and the concept of quality- based management (QMC); in the 2000s β the concept of quality management training, based on the concept of management by objectives; in the 2010s β the concept of quality management training, based on the active introduction of information technology; in the 2020s β the concept of quality management based on combinatorial technologies.Π‘ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΡΠ°Π»ΡΠ½ΡΡ
ΠΏΠΎΠ·ΠΈΡΠΈΠΉ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ, ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ² Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ² ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΠ½ΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΎΠΏΠΈΡΠ°Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠΌΠΈ ΡΡΠ°ΠΏΠ°ΠΌΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ: Π² 1900βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ² ΠΏΠΎ ΠΏΡΠΈΠ½ΡΡΡΠΌ ΡΡΠ°Π½Π΄Π°ΡΡΠ°ΠΌ; Π² 1910βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΡΡΠ΅ΡΠ° Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ² ΠΏΡΠΈ ΠΏΠΎΡΠΎΡΠ½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ; Π² 1920βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΌΠ°ΡΡΡΠ°Π±Π½ΠΎΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°; Π² 1930βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π½Π°Π΄Π΅ΠΆΠ½ΠΎΡΡΠΈ Π·Π½Π°Π½ΠΈΠΉ, ΡΠΌΠ΅Π½ΠΈΠΉ ΠΈ Π½Π°Π²ΡΠΊΠΎΠ², Π³Π°ΡΠ°Π½ΡΠΈΡΡΡΡΠΈΡ
ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΎΠ±ΡΡΠ°Π΅ΠΌΡΡ
ΡΠΎΡ
ΡΠ°Π½ΡΡΡ ΠΈΡ
Π² ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΡ
ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Π² Π·Π°Π΄Π°Π½Π½ΡΡ
Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Π°Ρ
; Π² 1940βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΡΡΠ΅ΡΠ΅ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΠΊΠ°Π΄ΡΠΎΠ² Π»ΡΡΡΠ΅Π³ΠΎ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΏΡΠ΅Π΄ΡΠ΄ΡΡΠΈΡ
ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ; Π² 1950βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ² ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠ°ΡΠ΅ΡΡΠ²Π°; Π² 1960βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄- Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², Π±Π°Π·ΠΈΡΡΡΡΠ΅ΠΉΡΡ Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΡ
ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ TQC ΠΈ CWQC Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°; Π² 1970βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², Π±Π°Π·ΠΈΡΡΡΡΠ΅ΠΉΡΡ Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ TQM; Π² 1980βΠ΅ Π³Π³. β ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΡΠ½ΠΎΠ²Ρ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΊΡΠ»ΡΡΡΡΡ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° ΠΊΠ°ΡΠ΅ΡΡΠ²Π° (UQM); Π² 1990βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², ΠΎΡΠ½ΠΎΠ²Π°Π½Π½Π°Ρ Π½Π° ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΡΡ
ΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° (QMC); Π² 2000βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², Π±Π°Π·ΠΈΡΡΡΡΠ΅ΠΉΡΡ Π½Π° ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΏΠΎ ΡΠ΅Π»ΡΠΌ; Π² 2010βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΊΠ°Π΄ΡΠΎΠ², ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° Π°ΠΊΡΠΈΠ²Π½ΠΎΠΌ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ; Π² 2020βΠ΅ Π³Π³. β ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠ΅ΠΉ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ Π½Π° Π±Π°Π·Π΅ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΎΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ
Input of Congress-Exhibition Services to the Economy of a Destination: Development of Assessment Methodology
Quantitative indicators of tourism development are presented: direct and common input of tourism to the global GDP, inο¬uence of the touristic sphere on employment and investment activity in 2015β2017. General approaches of tourism contribution evaluation to the destinationβs economy are systematized. They are analyzed in the context of applicability in the meetings industry. In order to develop methodological system of evaluation of the congress-exhibition contribution to the destination development, set of indicators is proposed. It includes four basic groups with certain valuation factors: group of economical and social factors, group of connected with destination promotion to the national and world markets, group of business-factors, and group of research intensity factors of a destinationβs industry sectors
Weight method for determination of soluble Ξ²-glucans in barley grain
Background. Barley (Hordeum vulgare L.) is an important source of nutrients, such as starch, protein, and various dietary fibers. Ξ²-Glucans are soluble fibers found in high amounts in oat and barley grain, so they are becoming increasingly interesting due to their numerous functional and bioactive properties. The increased interest in Ξ²-glucans as a dietary supplement and a functional component of food calls for a convenient, inexpensive and affordable method for quantitative determination of these compounds.Materials and methods. An overview is given on the existing techniques for determining and isolating Ξ²-glucans in cereals: IR spectroscopy, enzymatic, colorimetric, and alkaline-enzymatic methods. Their advantages and disadvantages are shown. The disadvantages of the methods considered include high costs of reagents and equipment, duration of performance, and labor intensity.Results. This study promotes the weight method for isolation and quantitative determination of Ξ²-glucans in the grain of covered and naked barley. It is based on the modified alkaline method adapted to barley; we developed it earlier for oat grain. The amount of Ξ²-glucans in the grain of the studied barley accessions ranged from 4.12Β±0.23% to 5.34 Β± 0.31% for naked cultivars, and from 3.57 Β± 0.18% to 4.29 Β± 0.32% for covered ones.Conclusion. Based on the conducted research, optimal conditions for the isolation and quantitative determination of Ξ²-glucans from barley grain were selected: centrifugation modes, temperature and extraction ratio, concentration of compounds, precipitation and drying procedures. The main advantage of the described method is its accessibility and practical applicability when conducting mass analysis, including studying a collection of cereal crops
ΠΠ΅ΡΠΎΡΡΠ½ΡΠ΅ ΡΡΠ΅Π½Π΄Ρ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π±Π°ΠΊΠ°Π»Π°Π²ΡΠΈΠ°ΡΠ° ΠΏΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ Β«ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΒ» Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΏΠΎΡΡΠΈΠ½Π΄ΡΡΡΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ
The paper considers processes of the managerial activity dynamics in the context of changing the economy technological patterns accompanied by the global financial crisis, and aggravated by the coronavirus pandemic, which led to localization, slowdown and even partial paralysis of many processes of socioeconomic development. Through the prism of ongoing the society socioeconomic changes, probable trends are described which transform the undergraduate curriculum content of the training direction Β«ManagementΒ» in the higher education system in modern conditions of the post-industrial economy development. As a description results of the process evolution of developing the practical applied directions of management synchronized with the concept evolution of developing management as a science formed within the framework of economic activity business cycles by K. Zhuglyar, it is shown that the next decade (2020-2030) the greatest development in the management practice (due to the socioeconomic development characteristics in the reviewed period) will receive such areas as communication management and coordination management.Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΡΠΎΡΠ΅ΡΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΡΡΠ΅ΠΉ ΡΠΌΠ΅Π½Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΊΠ»Π°Π΄ΠΎΠ² ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ΅ΠΉΡΡ ΠΌΠΈΡΠΎΠ²ΡΠΌ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΡΠΌ ΠΊΡΠΈΠ·ΠΈΡΠΎΠΌ ΠΈ ΠΎΡΡΠ³ΠΎΡΠ΅Π½Π½ΠΎΠΉ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠ΅ΠΉ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ°, ΠΏΡΠΈΠ²Π΅Π΄ΡΠ΅ΠΉ ΠΊ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΡ ΠΈ Π΄Π°ΠΆΠ΅ ΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ. Π‘ΠΊΠ²ΠΎΠ·Ρ ΠΏΡΠΈΠ·ΠΌΡ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΡΡΠΈΡ
ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅ ΠΎΠΏΠΈΡΠ°Π½Ρ Π²Π΅ΡΠΎΡΡΠ½ΡΠ΅ ΡΡΠ΅Π½Π΄Ρ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΡΠ΅Π±Π½ΡΡ
ΠΏΠ»Π°Π½ΠΎΠ² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π±Π°ΠΊΠ°Π»Π°Π²ΡΠΈΠ°ΡΠ° ΠΏΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ Β«ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΒ» Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΡΠΈΠ½Π΄ΡΡΡΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΡΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ°, ΡΠΈΠ½Ρ
ΡΠΎΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΡΠ²ΠΎΠ»ΡΡΠΈΠ΅ΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° ΠΊΠ°ΠΊ Π½Π°ΡΠΊΠΈ, ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΡ
ΡΡ Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π΄Π΅Π»ΠΎΠ²ΡΡ
ΡΠΈΠΊΠ»ΠΎΠ² ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π. ΠΡΠ³Π»ΡΡΠ°, ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² Π±Π»ΠΈΠΆΠ°ΠΉΡΠ΅Π΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΠ΅ (2020β2030βΠ΅ Π³Π³.) Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ (Π² ΡΠΈΠ»Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π² ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΠΌΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄) ΠΏΠΎΠ»ΡΡΠ°Ρ ΡΠ°ΠΊΠΈΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ, ΠΊΠ°ΠΊ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ ΠΈ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ
Assessment of Residual Virulence of Francisella tularensis 15 NIIEG Vaccine Strain Based on Long-term Observations
Objective of the study is to assess and analyze the long-term data on annual control of residual virulence of Francisella tularensis 15 NIIEG vaccine strain for clarifying the value of the parameter and amending the regulatory documentation. Materials and methods. Utilized were 8 vials containing lyophilized cultures of vaccine strain F. tularensis 15 NIIEG dated 1953, 1966, 1969, 1987, 1990, 2003, 2012, and 2013, manufactured at different industrial sites. To gather additional information on residual virulence of F. tularensis 15 NIIEG strain, evaluation of quality control files of 76 lyophilized cultures in vials was performed, out of which 48 strains manufactured at the premises of Odessa Bacterial Products Enterprise in 1980, 1987, and 1990, and 28 β at Joint Stock Company Scientific Production Association on Medical Immunobiological Preparations βMicrogenβ, Omsk Bacterial Products Enterprise, in 2003β2013. Results and discussion. Assessment of the parameter has revealed that out of 8 tested cultures of F. tularensis 15 NIIEG strain of various date of lyophilization 7 cultures have virulence rate ranging within 1Β·102 β 2.5Β·102 mc, LD50 of the strain dated 1966 is 7.3Β·105 mc (the standard range 1Β·102 β 2Β·106 mc). Obtained in the course of analysis of quality control files on F. tularensis 15 NIIEG strain, stored in lyophilized form at (19Β±1) Β°C, data demonstrate that residual virulence stays within the specified limits. Amendments regarding the value of βResidual virulenceβ parameter have been introduced into the regulatory documentation, the level ranging within 1Β·102 β 5Β·103 mc
Comparative analysis of the chemical composition and size of starch granules in grain between diploid and tetraploid sweetcorn cultivars
Background. Improving the taste and nutritional value of sweetcorn using genetic selection techniques is an important trend. The tetraploid sugary maize cultivar βBaksanskaya sakharnayaβ (k-23426) has a number of advantages in terms of taste and marketability over traditional diploid varieties.The purpose of the research was to identify the distinctive biochemical characteristics that affect the taste of this cultivar in comparison with the diploid reference (cv. βRannyaya Lakomkaβ, Ρ-1775).Materials and methods. The differences in phenotypic traits between diploid (2n) and tetraploid (4n) maize plants were assessed. Infrared spectroscopy was used to study the difference in the biochemical composition of kernels in terms of protein, starch and oil content. Accumulation of metabolites in a dry kernel was studied using gasβliquid chromatography with mass spectrometry.Results. Comparison of the phenotypic traits in 2n and 4n sweetcorn plants showed that 4n had a better ear structure, protein and oil content. Analysis of metabolites showed that quantitative indicators of chemical components changed in kernels of the 4n sweetcorn without changing the qualitative composition. The chemical composition of the metabolites in 4n sweetcorn grain was characterized by an increase in the synthesis of most organic acids and protein amino acids, phosphoric acid, fatty acids, some monosaccharides, phenolic compounds, and phytosterols. A decrease in the content of most polyhydric alcohols, disaccharides, trisaccharides, some monosaccharides, and phenolic compounds was observed. An inhibitory effect of a su2 gene dose on the size of starch granules was found.Β Conclusion. The studies showed the advantage of the 4n sweetcorn over the 2n one due to its improved ear structure and biochemical composition, which positively affected the taste qualities