D-Meson Mixing in Broken SU(3)

A fit of amplitudes to the experimental branching ratios to two mesons is used to construct a new estimate of neutral $D$ mixing which includes $SU(3)$ breaking. The result is dominated by the experimental uncertainties. This suggests that the charm sector may not be as sensitive to new physics as previously thought and that long-distance calculations may not be useful.Comment: 12 pages, LaTeX, no figure

Tables of SU(3) Isoscalar Factors

The Clebsch-Gordan coefficients of $SU(3)$ are useful in calculations involving baryons and mesons, as well as in calculations involving arbitrary numbers of quarks. For the latter case, one needs the coupling constants between states of nonintegral hypercharges. The existing published tables are insufficient for many such applications, and therefore we have compiled this collection. This report supplies the isoscalar factors required to reconstruct the Clebsch-Gordan coefficients for a large set of products of representations.Comment: LaTeX, 51 pages, no figures, MACROS INCLUDED IN NEW FIL

Program for Generating Tables of SU(3) Coupling Coefficients

A C-Language program which tabulates the isoscalar factors and Clebsch-Gordan coefficients for products of representations in SU(3) is presented. These are efficiently computed using recursion relations, and the results are presented in exact precision as square roots of rational numbers. Output is in LaTeX format.Comment: LaTeX, 29 pages, no figure

Pascal Program for Generating Tables of SU(3) Clebsch-Gordan Coefficients

Pascal routines are provided that generate representations of the group $SU(3)$ and tabulate the Clebsch-Gordan coefficients in the products of representations.Comment: 14 pages, LBL-3573

Mixing and CP-violation in charm

The motivation most often cited in searches for D0-anti-D0 mixing and CP-violation in charm system lies with the possibility of observing a signal from new physics which dominates that from the Standard Model. We review recent theoretical predictions and experimental constraints on D0-anti-D0 mixing parameters. We also discuss the current status of searches for CP-violation in charmed meson transitions, as well as some recent theoretical ideas.Comment: 7 pages, 1 figure, 1 table, invited talk at BEACH 2004, 6th international conference on Hyperons, Charm and Beauty Hadrons, Illionois Institute of Technology, Chicago, June 27 - July 3, 200

Nonleptonic Two-Body Decays of D Mesons in Broken SU(3)

Decays of the D mesons to two pseudoscalars, to two vectors, and to pseudoscalar plus vector are discussed in the context of broken flavor SU(3). A few assumptions are used to reduce the number of parameters. Amplitudes are fit to the available data, and predictions of branching ratios for unmeasured modes are made.Comment: LaTeX, 24 page

A Syngeneic Orthotopic Murine Model of Pancreatic Adenocarcinoma in the C57/BL6 Mouse Using the Panc02 and 6606PDA Cell Lines

Background/Aims: To develop a clinically relevant immunocompetent murine model to study pancreatic cancer using two different syngeneic pancreatic cancer cell lines and to assess MRI for its applicability in this model. Methods: Two cell lines, 6606PDA and Panc02, were employed for the experiments. Cell proliferation and migration were monitored in vitro. Matrigel™ was tested for its role in tumor induction. Tumor cell growth was assessed after orthotopic injection of tumor cells into the pancreatic head of C57/BL6 mice by MRI and histology. Results: Proliferation and migration of Panc02 were significantly faster than those of 6606PDA. Matrigel did not affect tumor growth/migration but prevented tumor cell spread after injection thus avoiding undesired peritoneal tumor growth. MRI could reliably monitor longitudinal tumor growth in both cell lines: Panc02 had a more irregular finger-like growth, and 6606PDA grew more spherically. Both tumors showed local invasiveness. Histologically, Panc02 showed a sarcoma-like undifferentiated growth pattern, whereas 6606PDA displayed a moderately differentiated glandular tumor growth. Panc02 mice had a significantly shorter (28 days) survival than 6606PDA mice (50 days). Conclusion: This model closely mimics human pancreatic cancer. MRI was invaluable for longitudinal monitoring of tumor growth thus reducing the number of mice required. Employing two different cell lines, this model can be used for various treatment and imaging studies

Resonant Two-body D Decays

The contribution of a $K^*(1430)$ $0^+$ resonance to $D^0\to K^-\pi^+$ is calculated by applying the soft pion theorem to $D^+ \to K^* \pi^+$, and is found to be about 30% of the measured amplitude and to be larger than the $\Delta I=3/2$ component of this amplitude. We estimate a 70% contribution to the total amplitude from a higher $K^*(1950)$ resonance. This implies large deviations from factorization in D decay amplitudes, a lifetime difference between D^0 and D^+, and an enhancement of $D^0-\bar D^0$ mixing due to SU(3) breaking.Comment: To be published in Physical Review Letters, some corrections, references update