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Measurement of the Vertical Emittance and beta-Function at the PEP-II Interaction Point Using the BaBar Detector
We present measurements of the effective vertical emittance and IP {beta}-function in the PEP-II asymmetric B Factory at SLAC. These beam parameters are extracted from fits to the longitudinal dependence of the luminosity and the vertical luminous size, measured using e{sup +}e{sup -} {yields} {mu}{sup +}{mu}{sup -} events recorded in the BABAR detector. The results are compared, for different sets of machine conditions, to accelerator-based measurements of the optical functions of the two beams
First Observation of the decay KL -> pi0 e e gamma
We report on the first observation of the decay KL -> pi0 ee gamma by the
KTeV E799 experiment at Fermilab. Based upon a sample of 48 events with an
estimated background of 3.6 +/- 1.1 events, we measure the KL -> pi0 ee gamma
branching ratio to be (2.34 +/- 0.35 +/- 0.13)x10^{-8}. Our data agree with
recent O(p^6) calculations in chiral perturbation theory that include
contributions from vector meson exchange through the parameter a_V. A fit was
made to the KL -> pi0 ee gamma data for a_V with the result -0.67 +/- 0.21 +/-
0.12, which is consistent with previous results from KTeV.Comment: Submitted to Physical Review Letters, 5 pages, 5 figure
SuperB: a linear high-luminosity B Factory
This paper is based on the outcome of the activity that has taken place
during the recent workshop on "SuperB in Italy" held in Frascati on November
11-12, 2005. The workshop was opened by a theoretical introduction of Marco
Ciuchini and was structured in two working groups. One focused on the machine
and the other on the detector and experimental issues.
The present status on CP is mainly based on the results achieved by BaBar and
Belle. Estabilishment of the indirect CP violation in B sector in 2001 and of
the direct CP violation in 2004 thanks to the success of PEP-II and KEKB e+e-
asymmetric B Factories operating at the center of mass energy corresponding to
the mass of the Y(4s). With the two B Factories taking data, the Unitarity
Triangle is now beginning to be overconstrained by improving the measurements
of the sides and now also of the angles alpha, and gamma. We are also in
presence of the very intriguing results about the measurements of sin(2 beta)
in the time dependent analysis of decay channels via penguin loops, where b -->
s sbar s and b --> s dbar d. Tau physics, in particular LFV search, as well as
charm and ISR physics are important parts of the scientific program of a SuperB
Factory. The physics case together with possible scenarios for the high
luminosity SuperB Factory based on the concepts of the Linear Collider and the
related experimental issues are discussed.Comment: 22 pages, 22 figures, INFN Roadmap Repor
Paget's disease of the skull causing hyperprolactinemia and erectile dysfunction: a case report
<p>Abstract</p> <p>Introduction</p> <p>Hyperprolactinemia is an uncommon cause of erectile dysfunction in men. Paget's disease of the skull is a relatively common disease. This case proposes a rare example of a causative link between the two and how treatment of the Paget's disease with bisphosphonates helped the patient regain erectile function.</p> <p>Case presentation</p> <p>A 67-year-old man with Paget's disease of the skull presented with prostatitis, erectile dysfunction, and hyperprolactinemia. Radio-isotope scanning showed increased vascularity around the sphenoid bone. Treatment with intravenous bisphosphonates improved the active Paget's disease as indicated by declining alkaline phosphatase levels and the patient's erectile function while serum prolactin levels became normal and serum testosterone levels remained unchanged.</p> <p>Conclusion</p> <p>It is possible that hyperprolactinemia is unrecognised in other patients with Paget's disease of the skull. Normalizing elevated prolactin levels by using bisphosphonates in treating Paget's disease appears to be more appropriate than traditional treatment for hyperprolactinemia.</p
Brown dwarf census with the Dark Energy Survey year 3 data and the thin disc scale height of early L types
27 pages, 18 figuresIn this paper we present a catalogue of 11 745 brown dwarfs with spectral types ranging from L0 to T9, photometrically classified using data from the Dark Energy Survey (DES) year 3 release matched to the Vista Hemisphere Survey (VHS) DR3 and Wide-field Infrared Survey Explorer (WISE) data, covering ≈2400 deg2 up to iAB = 22. The classification method follows the same phototype method previously applied to SDSS-UKIDSS-WISE data. The most significant difference comes from the use of DES data instead of SDSS, which allow us to classify almost an order of magnitude more brown dwarfs than any previous search and reaching distances beyond 400 pc for the earliest types. Next, we also present and validate the GalmodBD simulation, which produces brown dwarf number counts as a function of structural parameters with realistic photometric properties of a given survey. We use this simulation to estimate the completeness and purity of our photometric LT catalogue down to iAB = 22, as well as to compare to the observed number of LT types. We put constraints on the thin disc scale height for the early L (L0–L3) population to be around 450 pc, in agreement with previous findings. For completeness, we also publish in a separate table a catalogue of 20 863 M dwarfs that passed our colour cut with spectral types greater than M6. Both the LT and the late M catalogues are found at DES release page https://des.ncsa.illinois.edu/releases/other/y3-mlt.Peer reviewedFinal Published versio
Photometric redshifts and clustering of emission line galaxies selected jointly by DES and eBOSS
We present the results of the first test plates of the extended Baryon
Oscillation Spectroscopic Survey. This paper focuses on the emission line
galaxies (ELG) population targetted from the Dark Energy Survey (DES)
photometry. We analyse the success rate, efficiency, redshift distribution, and
clustering properties of the targets. From the 9000 spectroscopic redshifts
targetted, 4600 have been selected from the DES photometry. The total success
rate for redshifts between 0.6 and 1.2 is 71\% and 68\% respectively for a
bright and faint, on average more distant, samples including redshifts measured
from a single strong emission line. We find a mean redshift of 0.8 and 0.87,
with 15 and 13\% of unknown redshifts respectively for the bright and faint
samples. In the redshift range 0.6<z<1.2, for the most secure spectroscopic
redshifts, the mean redshift for the bright and faint sample is 0.85 and 0.9
respectively. Star contamination is lower than 2\%. We measure a galaxy bias
averaged on scales of 1 and 10~Mpc/h of 1.72 \pm 0.1 for the bright sample and
of 1.78 \pm 0.12 for the faint sample. The error on the galaxy bias have been
obtained propagating the errors in the correlation function to the fitted
parameters. This redshift evolution for the galaxy bias is in agreement with
theoretical expectations for a galaxy population with MB-5\log h < -21.0. We
note that biasing is derived from the galaxy clustering relative to a model for
the mass fluctuations. We investigate the quality of the DES photometric
redshifts and find that the outlier fraction can be reduced using a comparison
between template fitting and neural network, or using a random forest
algorithm
Precise Measurements of Direct CP Violation, CPT Symmetry, and Other Parameters in the Neutral Kaon System
We present precise tests of CP and CPT symmetry based on the full dataset of
K to pipi decays collected by the KTeV experiment at Fermi National Accelerator
Laboratory during 1996, 1997, and 1999. This dataset contains 16 million K to
2pi0 and 69 million K to pi+pi- decays. We measure the direct CP violation
parameter Re(epsilon'/epsilon) = (19.2 pm 2.1)x10-4. We find the KL-KS mass
difference Deltam = (5270 pm 12)x10^6 hbar/s and the KS lifetime tauS = (89.62
pm 0.05)x10-12 s. We also measure several parameters that test CPT invariance.
We find the difference between the phase of the indirect CP violation
parameter, epsilon, and the superweak phase, phi_epsilon - phi_SW = (0.40 pm
0.56) degrees. We measure the difference of the relative phases between the CP
violating and CP conserving decay amplitudes for K to pi+pi- (phi+-) and for K
to 2pi0 (phi00), Delta phi = (0.30 pm 0.35) degrees. From these phase
measurements, we place a limit on the mass difference between K0 and K0bar,
DeltaM < 4.8 x 10-19 GeV/c^2 at 95% C.L. These results are consistent with
those of other experiments, our own earlier measurements, and CPT symmetry.Comment: 28 pages, 30 figures; removed extra figur
Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone
Measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) and mutation of the SQSTM1 (p62) gene contribute to the increased OCL activity in Paget's disease (PD). OCLs expressing MVNP display many of the features of PD OCLs. Interleukin-6 (IL-6) production is essential for the pagetic phenotype, because transgenic mice with MVNP targeted to OCLs develop pagetic OCLs and lesions, but this phenotype is absent when MVNP mice are bred to IL-6(-/-) mice. In contrast, mutant p62 expression in OCL precursors promotes receptor activator of NF-κB ligand (RANKL) hyperresponsivity and increased OCL production, but OCLs that form have normal morphology, are not hyperresponsive to 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3 ), nor produce elevated levels of IL-6. We previously generated p62(P394L) knock-in mice (p62KI) and found that although OCL numbers were increased, the mice did not develop pagetic lesions. However, mice expressing both MVNP and p62KI developed more exuberant pagetic lesions than mice expressing MVNP alone. To examine the role of elevated IL-6 in PD and determine if MVNP mediates its effects primarily through elevation of IL-6, we generated transgenic mice that overexpress IL-6 driven by the tartrate-resistant acid phosphatase (TRAP) promoter (TIL-6 mice) and produce IL-6 at levels comparable to MVNP mice. These were crossed with p62KI mice to determine whether IL-6 overexpression cooperates with mutant p62 to produce pagetic lesions. OCL precursors from p62KI/TIL-6 mice formed greater numbers of OCLs than either p62KI or TIL-6 OCL precursors in response to 1,25-(OH)2 D3 . Histomorphometric analysis of bones from p62KI/TIL-6 mice revealed increased OCL numbers per bone surface area compared to wild-type (WT) mice. However, micro-quantitative CT (µQCT) analysis did not reveal significant differences between p62KI/TIL-6 and WT mice, and no pagetic OCLs or lesions were detected in vivo. Thus, increased IL-6 expression in OCLs from p62KI mice contributes to increased responsivity to 1,25-(OH)2 D3 and increased OCL numbers, but is not sufficient to induce Paget's-like OCLs or bone lesions in vivo
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3in vivo
Background
Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of OC seen after 1,25-(OH)2D3 administration in vivo is unclear. There is evidence that the normal fate of OC is to undergo apoptosis (programmed cell death). We have investigated the effect of short-term application of high dose 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on OC apoptosis in an experimental rat model.
Methods
OC recruitment, augmentation and apoptosis was visualised and quantitated by staining histochemically for tartrate resistant acid phosphatase (TRAP), double staining for TRAP/ED1 or TRAP/DAPI, in situ DNA fragmentation end labelling and histomorphometric analysis.
Results
Short-term treatment with high-dose 1,25-(OH)2D3 increased the recruitment of OC precursors in the bone marrow resulting in a short-lived increase in OC numbers. This was rapidly followed by an increase in the number of apoptotic OC and their subsequent removal. The response of OC to 1,25-(OH)2D3 treatment was dose and site dependent; higher doses producing stronger, more rapid responses and the response in the tibiae being consistently stronger and more rapid than in the vertebrae.
Conclusions
This study demonstrates that (1) after recruitment, OC are removed from the resorption site by apoptosis (2) the combined use of TRAP and ED1 can be used to identify OC and their precursors in vivo (3) double staining for TRAP and DAPI or in situ DNA fragmentation end labelling can be used to identify apoptotic OC in vivo
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