493 research outputs found
Modeling Concept Combinations in a Quantum-theoretic Framework
We present modeling for conceptual combinations which uses the mathematical
formalism of quantum theory. Our model faithfully describes a large amount of
experimental data collected by different scholars on concept conjunctions and
disjunctions. Furthermore, our approach sheds a new light on long standing
drawbacks connected with vagueness, or fuzziness, of concepts, and puts forward
a completely novel possible solution to the 'combination problem' in concept
theory. Additionally, we introduce an explanation for the occurrence of quantum
structures in the mechanisms and dynamics of concepts and, more generally, in
cognitive and decision processes, according to which human thought is a well
structured superposition of a 'logical thought' and a 'conceptual thought', and
the latter usually prevails over the former, at variance with some widespread
beliefsComment: 5 pages. arXiv admin note: substantial text overlap with
arXiv:1311.605
Classical Logical versus Quantum Conceptual Thought: Examples in Economics, Decision theory and Concept Theory
Inspired by a quantum mechanical formalism to model concepts and their
disjunctions and conjunctions, we put forward in this paper a specific
hypothesis. Namely that within human thought two superposed layers can be
distinguished: (i) a layer given form by an underlying classical deterministic
process, incorporating essentially logical thought and its indeterministic
version modeled by classical probability theory; (ii) a layer given form under
influence of the totality of the surrounding conceptual landscape, where the
different concepts figure as individual entities rather than (logical)
combinations of others, with measurable quantities such as 'typicality',
'membership', 'representativeness', 'similarity', 'applicability', 'preference'
or 'utility' carrying the influences. We call the process in this second layer
'quantum conceptual thought', which is indeterministic in essence, and contains
holistic aspects, but is equally well, although very differently, organized
than logical thought. A substantial part of the 'quantum conceptual thought
process' can be modeled by quantum mechanical probabilistic and mathematical
structures. We consider examples of three specific domains of research where
the effects of the presence of quantum conceptual thought and its deviations
from classical logical thought have been noticed and studied, i.e. economics,
decision theory, and concept theories and which provide experimental evidence
for our hypothesis.Comment: 14 page
Quantum Experimental Data in Psychology and Economics
We prove a theorem which shows that a collection of experimental data of
probabilistic weights related to decisions with respect to situations and their
disjunction cannot be modeled within a classical probabilistic weight structure
in case the experimental data contain the effect referred to as the
'disjunction effect' in psychology. We identify different experimental
situations in psychology, more specifically in concept theory and in decision
theory, and in economics (namely situations where Savage's Sure-Thing Principle
is violated) where the disjunction effect appears and we point out the common
nature of the effect. We analyze how our theorem constitutes a no-go theorem
for classical probabilistic weight structures for common experimental data when
the disjunction effect is affecting the values of these data. We put forward a
simple geometric criterion that reveals the non classicality of the considered
probabilistic weights and we illustrate our geometrical criterion by means of
experimentally measured membership weights of items with respect to pairs of
concepts and their disjunctions. The violation of the classical probabilistic
weight structure is very analogous to the violation of the well-known Bell
inequalities studied in quantum mechanics. The no-go theorem we prove in the
present article with respect to the collection of experimental data we consider
has a status analogous to the well known no-go theorems for hidden variable
theories in quantum mechanics with respect to experimental data obtained in
quantum laboratories. For this reason our analysis puts forward a strong
argument in favor of the validity of using a quantum formalism for modeling the
considered psychological experimental data as considered in this paper.Comment: 15 pages, 4 figure
What is Quantum? Unifying Its Micro-Physical and Structural Appearance
We can recognize two modes in which 'quantum appears' in macro domains: (i) a
'micro-physical appearance', where quantum laws are assumed to be universal and
they are transferred from the micro to the macro level if suitable 'quantum
coherence' conditions (e.g., very low temperatures) are realized, (ii) a
'structural appearance', where no hypothesis is made on the validity of quantum
laws at a micro level, while genuine quantum aspects are detected at a
structural-modeling level. In this paper, we inquire into the connections
between the two appearances. We put forward the explanatory hypothesis that,
'the appearance of quantum in both cases' is due to 'the existence of a
specific form of organisation, which has the capacity to cope with random
perturbations that would destroy this organisation when not coped with'. We
analyse how 'organisation of matter', 'organisation of life', and 'organisation
of culture', play this role each in their specific domain of application, point
out the importance of evolution in this respect, and put forward how our
analysis sheds new light on 'what quantum is'.Comment: 10 page
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
BACKGROUND: The main role of the cell cycle is to enable error-free DNA replication, chromosome segregation and cytokinesis.
One of the best characterised checkpoint pathways is the spindle assembly checkpoint, which prevents anaphase onset until the
appropriate attachment and tension across kinetochores is achieved. MPS1 kinase activity is essential for the activation of the
spindle assembly checkpoint and has been shown to be deregulated in human tumours with chromosomal instability and
aneuploidy. Therefore, MPS1 inhibition represents an attractive strategy to target cancers.
METHODS: To evaluate CCT271850 cellular potency, two specific antibodies that recognise the activation sites of MPS1 were used
and its antiproliferative activity was determined in 91 human cancer cell lines. DLD1 cells with induced GFP-MPS1 and HCT116
cells were used in in vivo studies to directly measure MPS1 inhibition and efficacy of CCT271850 treatment.
RESULTS: CCT271850 selectively and potently inhibits MPS1 kinase activity in biochemical and cellular assays and in in vivo models.
Mechanistically, tumour cells treated with CCT271850 acquire aberrant numbers of chromosomes and the majority of cells divide
their chromosomes without proper alignment because of abrogation of the mitotic checkpoint, leading to cell death. We
demonstrated a moderate level of efficacy of CCT271850 as a single agent in a human colorectal carcinoma xenograft model.
CONCLUSIONS: CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo
pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to
achieve tumour stasis or regression by CCT271850
Rapid Discovery of Pyrido[3,4- d ]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach
Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint. Chromosomally unstable cancer cells rely heavily on MPS1 to cope with the stress arising from abnormal numbers of chromosomes and centrosomes and are thus more sensitive to MPS1 inhibition than normal cells. We report the discovery and optimization of a series of new pyrido[3,4-d]pyrimidine based inhibitors via a structure-based hybridization approach from our previously reported inhibitor CCT251455 and a modestly potent screening hit. Compounds in this novel series display excellent potency and selectivity for MPS1, which translates into biomarker modulation in an in vivo human tumor xenograft mode
Precipitation of Trichoderma reesei commercial cellulase preparations under standard enzymatic hydrolysis conditions for lignocelluloses
Comparative studies between commercial Trichoderma reesei cellulase preparations show that, depending on the preparation and loading, total protein precipitation can be as high as 30 % under standard hydrolysis conditions used for lignocellulosic materials. ATR-IR and SDS-PAGE data verify precipitates are protein-based and contain key cell wall hydrolyzing enzymes. Precipitation increased considerably with incubation temperature; roughly 50–150 % increase from 40 to 50 °C and 800 % greater at 60 °C. All of the reported protein losses translated into significant, and often drastic, losses in activity on related 4-nitrophenyl substrates. In addition, supplementation with the non-ionic surfactant PEG 6,000 decreased precipitation up to 80 % in 24 h precipitation levels. Protein precipitation is potentially substantial during enzymatic hydrolysis of lignocelluloses and should be accounted for during lignocellulose conversion process design, particularly when enzyme recycling is considered.This work was supported by the project "Demonstrating Industrial scale second generation bioethaol production-Kalundborg Cellulosic Ethanol Plant" under the EU FP7 framework program and the project "Development of improved second generation (2G) bioethanol technology to prepare for commercialization under the Danish Energy Technology and Demonstration Programme (EUDP)
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