CHANGES IN SPERMIOGRAMS, BIOCHEMICAL AND PHYSIOLOGICAL INDICES FOLLOWING SUCCESSIVE ELECTROEJACULATION DURING DIFFERENT PERIODS OF THE DAY IN WEST AFRICAN DWARF BUCKS

This study was conducted to investigate the changes that might occur in spermiograms, blood andphysiological indices following successive electroejaculation (EE) during different periods of the day.Twenty (20) West African Dwarf (WAD) bucks were grouped into four consisting of five bucks eachand ejaculated at 0900, 1200, 0300 and 0600Hrs for 3 successive days in a completely randomizeddesign. The results showed that progressive sperm motility, sperm concentration and mass activityfollowed similar trend and the values deteriorated with respect to elevated temperatures during semencollection periods (p<0.05). Also, primary abnormality increased with respect to elevated temperaturesduring semen collection periods (p<0.05). The results also showed that Testosterone, Na+,K+,GlucoseAlanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and Aspartate Aminotransferase(AST) were similar irrespective of the periods of semen collection except cortisol that increased withrespect to the semen collection periods (p<0.05). The rectal temperature and pulse rate were not affected,irrespective of the period of the day bucks were ejaculated. The findings of this study indicatethat reduced ejaculate quality probably reflects stress stimuli arising from increased ambient temperature.Physiological traits in WAD goat is probably the adaptive mechanism evolved to cope with stressarising from elevated temperature

Development of a realtime microcomputer-based logging system for diagnosis and research

In this research, a realtime temperature logging system that logs human temperature into the computer over a period was developed and the temperature chart produced is useful for diagnosis and research purposes. The graphical representation within the threshold temperature (36°C) depicts normal body temperature of a healthy person. An upshot beyond this temperature makes the logger to signal an audible alarm for medical attention. It consists of hardware and software units. The hardware consists of sensor NTC (negative coefficient of temperature) thermistor, pre-amp; analog to digital converter, buffer between analog to digital converter and computer interface port. The software was developed in Visual Basic 6.0 for interfacing through the parallel port of the computer and the program designed to provide a user-friendly environment where the measurement can be read. There is high correlation between the approach developed by this study and other standard measuring equipments — correlation of 0.994574 with standard thermistor, and correlation of 0.997785 with standard thermocouple. The temperature logged to the PC can also be viewed from another PC remotely located over a network thus providing a good framework for telemedicine

EFFECT OF UROMAIZ ON SPERM CHARACTERISTICS IN WEST AFRICAN DWARF BUCKS

The effect of uromaiz, slow ammonia releasing urea product, produced by autoclaving and drying ofgerminated maize and urea on semen characteristics was investigated in twenty West African Dwarf(WAD) bucks in a completely randomized design experiment. The bucks were 11 and 13 months oldand they weighed 9.26+1.33kg. The bucks were assigned to five treatment groups and fed 0, 25, 50,75 and 100% uromaiz inclusion in the diet for eight weeks while data collection was carried out weeklyat the last four weeks. The results showed that important semen characteristics such as semen volume,sperm motility, sperm concentration and Sperm number per ejaculate increased (p<0.05) at 25and 50% levels of inclusion and reduced at higher levels of 75% and 100%. Primary abnormality locatedin the head, midpiece and tail increased (p<0.05) with increasing levels of uromaiz inclusion butvalues obtained were within the acceptable range for optimal fertility. The findings of this study indicatethat uromaiz at 25% or 50% could be included in the diet of WAD bucks to enhance sperm quality

Inflow forecasting using Artificial Neural Networks for reservoir operation

In this study, multi-layer perceptron (MLP) artificial neural networks have been applied to forecast one-month-ahead inflow for the Ubonratana reservoir, Thailand. To assess how well the forecast inflows have performed in the operation of the reservoir, simulations were carried out guided by the systems rule curves. As basis of comparison, four inflow situations were considered: (1) inflow known and assumed to be the historic (Type A); (2) inflow known and assumed to be the forecast (Type F); (3) inflow known and assumed to be the historic mean for month (Type M); and (4) inflow is unknown with release decision only conditioned on the starting reservoir storage (Type N). Reservoir performance was summarised in terms of reliability, resilience, vulnerability and sustainability. It was found that Type F inflow situation produced the best performance while Type N was the worst performing. This clearly demonstrates the importance of good inflow information for effective reservoir operation

EVALUATION OF ANALGESIC, ANTICONVULSANT AND HYPNOTIC ACTIVITIES OF PYRENACANTHIA STAUNDTII

An Aqueous leaf extract of Pyrenacanthia Staundtii (AqPs) was studied for central nervous activities. The extract (100.0 – 400.0 mg/kg i. p). significantly (

Amenamevir: Studies of Potential CYP2C8- and CYP2B6-Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers.

Amenamevir (formerly ASP2151) induces cytochrome P450 (CYP)2B6 and CYP3A4 and inhibits CYP2C8.  We conducted 2 studies, 1 using montelukast as a probe to assess CYP2C8 and the other bupropion to assess CYP2B6.  The montelukast study examined the effect of amenamevir on the pharmacokinetics of montelukast in 24 healthy men: each subject received montelukast 10 mg alone, followed by montelukast 10 mg with amenamevir 400 mg, or vice versa after a washout period.  In the bupropion study, 24 subjects received a single dose of 150 mg bupropion on days 1, 15, 22, and 29, and repeated once-daily doses of 400 mg amenamevir on days 6-15.  Amenamevir increased peak concentration and area under the concentration-time curve of montelukast by about 22% (ratio 121.7%, 90%CI [114.8, 129.1]; 121% [116.2, 128.4], respectively) with a similar increase in hydroxymontelukast (ratio 121.4%, 90%CI [106.4, 138.5]; 125.6 % [111.3, 141.7]).  Amenamevir reduced peak concentration and area under the concentration-time curve of bupropion by 16% (84.29%, 90%CI [78.00, 91.10]; 84.07%, 90%CI [78.85, 89.63]), with recovery after 1 week; the pharmacokinetics of the primary metabolite hydroxybupropion was unaffected.  Thus, amenamevir increased plasma concentrations of montelukast and decreased those of bupropion, but it did not do so enough to require dose adjustment of coadministered substrates of either CYP2C8 or CYP2B6.Maruh

Haematological and hepatic indices of cockerels fed treated dietary Blighia sapida seeds

Ninety-six day old Lairier cockerel chicks were used in an experiment to evaluate the after effects of detoxifying (soaking, boiling, addition of riboflavin and glycine to antagonize hypoglycins) dietary Blighia sapida (ackee apple) seed meal, BSSM. Blood chemistry, haematology, liver morphology indices which dietary BSSM influenced and reflected in the performance characteristics of the cockerels investigated in a single-factor experimental design experiment were assessed. Results showed that the residual phytotoxins of BSSM, hypoglycins A & B with their metabolite MCPA at 17.50% inclusion of the processed BSSM in diets elicited reduction in glucose, protein, albumin, globulin while elevating blood cholesterol, creatinine, urea,total and conjugated bilirubin relative to the reference diet (p <0.05).Dietary BSSM similarly increased the transaminase activities of AST/SGOT, ALT/SGPT including ACP (p < 0.05). BSSM based diets also caused significant reduction in PCV, RBC, WBC, Hb as well as MCV, MCH and MCHC similar to the results obtained on WBC differential counts of neutrophils and lymphocytes in comparison with the conventional diet (p < 0.05). Histopathological examinations on the liver samples revealed that the control diet presented livers that were normal in tissue morphology without inflammation or haemorrhage while the photomicrographs of the liver samples of cockerels fed treated dietary BSSM at 17.50% inclusion showed morphological patterns indicating severe distortion suggesting evidence of haemorrhage and inflammation with numerous blood cells occupying the available hepatic sinuses. The poor results recorded on the biochemical, haematological and morphological parameters were reflected in performance characteristics as reduced feed intake, weight gain, growth rate, feed efficiency and high mortality were obtained on diets containing BSSM compared with the orthodox diet (p < 0.05). Findings of this experiment indicated that for optimum results, processed BSSM be included in diets below the 17.50% level considered high for the birds in this study

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

Background The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD. Methods We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities. Results 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity. Conclusions The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD