Glycemic Profile of Patients on Hydroxychloroquine

BACKGROUND: Hypoglycemia is a known adverse effect of treatment with Hydroxychloroquine. Diabetes Mellitus is the leading metabolic disease world wide. The higher cost of the existing oral hypoglycemic agents have led to the development of a number of newer oral hypoglycemic agents. Hydroxy chloroquine, an old drug which is comparatively cheaper can be considered for the treatment of diabetes, if it is found to be effective. OBJECTIVE: To compare the efficacy of Hydroxychloroquine in decreasing the blood glucose in patients suffering from rheumatic diseases. METHODS: 100 patients newly diagnosed with a rheumatological disease were selected of which 70 had Rheumatoid arthritis and 30 had Systemic lupus erythematosus. Baseline HbA1c, FBS and PPBS were measured and compared after 3 months of treatment with Hydroxychloroquine at a dose of 200 mg twice daily. Efficacy is assessed by the changes in HbA1c, Fasting and Post prandial Blood Glucose after 3 months. RESULTS: Out of the 100 patients chosen for the study, 30 were Diabetic, 30 were Impaired glucose tolerant and 40 were Normal glucose tolerant at the beginning of the study. At the end of 3 months mean decrease in HbA1c was 0.362, 0.29 and 0.29% in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. All of them had a p value of 0.001 and was highly significant. Mean decrease in Fasting blood sugar was 10.42 mg/dl, 8.44 and 8.44 mg/dl in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. All of them had a p value of 0.001 and was highly significant. Mean decrease in Postprandial blood sugar was 6.2 mg/dl, 3.97 and 3.97 mg/dl in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. The p value in Diabetes, patients, Impaired glucose tolerant and Normal glucose tolerant patients were 0.148, 0.127 and 0.127 respectively and were not significant. CONCLUSION: Hydroxychloroquine has greater effect in decreasing blood glucose in Diabetes Mellitus compared to patients with Impaired and Normal glucose tolerance

An Experimental Study on Short Term Durability and Hardened Properties of Baggasse Ash and Fly Ash Based Geo Polymer Concrete

This project reports the comparison of bagasse ash and fly ash-bagasse ash based on geopolymer concrete. In which cement is fully replaced by pozzolanic material that is rich in silicon and aluminium like fly ash and bagasse ash referred to as “Geopolymer concrete” which is a contemporary material. Geopolymer concrete was actually manufactured by reusing and recycling of industrial solid wastes and by products. Fly Ash, a by-product of coal obtained from the thermal power plant is plenty available worldwide. Fly ash is used as ingredients in concrete which enhance the properties of concrete and utilization of fly ash is helpful for consumption. Bagasse ash is a final waste product of sugar obtained from the sugar mills. The base material, viz. fly ash and Bagasse ash, is activated by alkaline solution that is sodium hydroxide and sodium silicate to produce a binder which is rich in silica and aluminium. Sample 1 is cement.  It is replaced by 100% fly ash geopolymer concrete and trial 2 is 10%, 30% & 50% replaced by  Bagasse ash in Geopolymer concrete . The project presents the strength and durability of Bagasse ash based Geopolymer concrete and fly ash and Bagasse ash based Geopolymer concrete

A prospective comparative study of intestinal anastomosis, single layer extramucosal versus double layer

Background: Intestinal anastomosis is an operative procedure that is of central importance in the practice of surgery. Intestinal anastomosis after resection of bowel may be of various types and techniques. This prospective comparative study is performed to evaluate the safety in term of anastomotic leak of single layer interrupted extramucosal technique as compared to conventional double layer technique.Methods: The patients selected for this study are those who were admitted with various clinical conditions requiring resection and anastomosis of small or large bowel presented to P.D.U. Medical College & Hospital, Rajkot between a period of August 2012 to December 2014. A total of 50 patients were included in the study. All the patients above the age of 18 years and less than 60 years, requiring intestinal anastomosis on emergency or electively, were included in the study and those requiring anastomosis to esophageal, gastric and duodenal anastomosis were excluded and randomly allotted single layer and double layer groups and results such as anastomotic leak rate, duration for anastomosis, number of suture material required noted.Results: Mean duration required for single layer anastomosis was 19.6 minutes and for double layer anastomosis was 29.5 minutes and double number of suture material used in double layer anastomosis with equal anastomotic leak rate (6%) in each group.Conclusions: Single layer interrupted extramucosal technique required significantly less duration for anastomosis, is cost effective with no significant difference in anastomotic leak rate and  as safe as conventional double layer technique.

Implementation of a 4-tier Cloud-Based Architecture for Collaborative Health Care Delivery

Cloud services permit healthcare providers to ensure information handling and allow different service resources such as Software as a Service (SaaS), Platform as a Service (PaaS) and Infrastructure as a Service (IaaS) on the Internet, given that security and information proprietorship concerns are attended to. Health Care Providers (HCPs) in Nigeria however, have been confronted with various issues because of their method of operations. Amongst the issues are ill-advised methods of data storage and unreliable nature of patient medical records. Apart from these challenges, trouble in accessing quality healthcare services, high cost of medical services, and wrong analysis and treatment methodology are not left out. Cloud Computing has relatively possessed the capacity to give proficient and reliable method for securing medical information and the need for data mining tools in this form of distributed system will go a long way in achieving the objective set out for this project. The aim of this research therefore is to implement a cloud-based architecture that is suitable to integrate Healthcare Delivery into the cloud to provide a productive mode of operation. The proposed architecture consists of four phases (4-Tier); a User Authentication and Access Control Engine (UAACE) which prevents unauthorized access to patient medical records and also utilizes standard encryption/decoding techniques to ensure privacy of such records. The architecture likewise contains a Data Analysis and Pattern Prediction Unit (DAPPU) which gives valuable data that guides decision making through standard Data mining procedures as well as Cloud Service Provider (CSP) and Health Care Providers (HCPs). The architecture which has been implemented on CloudSim has proved to be efficient and reliable base on the results obtained when compared with previous work

Do analysts’\u27 forecast properties deter suboptimal labor investment decisions? Evidence from Regulation Fair Disclosure

We examine whether analyst forecast properties deter inefficient labor investment decisions. Using accuracy and dispersion as analyst forecast properties, we find that more accurate and less dispersed forecasts are associated with less inefficient corporate labor investments. We Utilizing Regulation Fair Disclosure (Reg FD) as an exogenous variation to analyst forecasts\u27 activities we find a causal relationship between analyst forecast properties and labor investment inefficiency. We also find that more accurate and less dispersed forecasts decrease labor cost stickiness. Our results are consistent with the view that analyst forecast properties enhance the information environment, which, in turn, improves corporate labor investment decisions

Tax Incentives for Green Industries: Determinants of Performance Between Green Building Index (GBI) and Non-Green Building Index Firms in Malaysia

Industrialization, urbanization, and economic growth are among the major causes of environmental degradation. These factors are closely related to the construction sector. To curb the issue, the government has initiated tax incentives to encourage developers embracing green technology. Developers who entitled to these tax incentives should enjoy a considerable amount of tax savings, which can be employed for capital reinvestment. Consequently, this study aims to determine whether firms that specifically involve with the construction of green buildings and have received the tax incentives are more likely to achieve relatively better financial performance, as a result of tax benefits gained from the government assistance. For the empirical analyses, secondary data was employed. A total of 138 firm-year observations from 2015 until 2017 used to measure the firm's characteristic of board size, asset tangibility, deferred tax balances, and leverage against financial performance. The Theory of the Growth of the Firm was used to interpret the relationship between the financial characteristics and firm performance. We obtain evidence that indicates there is no significant difference in the financial performance between the GBI and non-GBI firms. The deferred tax balance, a proxy of the investment tax allowances granted by the Malaysian government to the GBI firms, is shown to be ineffective in improving the financial performances of these firms. The finding of this study suggests that any form of tax assistance from the government for the construction sector has not benefitted its recipients and requires remodeling

Pd-catalyzed oxidative kinetic resolution of 2-azido-1-arylethanols

1533-1535(-)-Sparteine/ Pd (II) complex in combination with oxygen as a stoichiometric oxidant, catalyses the oxidative kinetic resolution of β-azido alcohols to afford the corresponding chiral 2-azido-1-arylethanol