Why to open the closed health care?

The article deals with modern aspects of the communication policy in the field of public health. A classic paternalistic and new market (partner) model of interaction in the «doctor-patient» system is described. A hypothesis has been put forward that the crisis of the relationship between the medical and patient communities is the result of a change in the paradigm of behavior caused by economic transformations in the state. To strengthen the regime of citizens’ trust in the national health care system, the necessity of intensifying the communication campaigns of the Ministry of Health of Russia in response to the unfair unilateral information coverage of the media situation in Russian medicine is justified

Instantaneous Radio Spectra of Giant Pulses from the Crab Pulsar from Decimeter to Decameter Wavelengths

The results of simultaneous multifrequency observations of giant radio pulses from the Crab pulsar, PSR B0531+21, at 23, 111, and 600 MHz are presented and analyzed. Giant pulses were detected at a frequency as low as 23 MHz for the first time. Of the 45 giant pulses detected at 23 MHz, 12 were identified with counterparts observed simultaneously at 600 MHz. Of the 128 giant pulses detected at 111 MHz, 21 were identified with counterparts observed simultaneously at 600 MHz. The spectral indices for the power-law frequency dependence of the giant-pulse energies are from -3.1 to -1.6. The mean spectral index is -2.7 +/- 0.1 and is the same for both frequency combinations (600-111 MHz and 600-23 MHz). The large scatter in the spectral indices of the individual pulses and the large number of unidentified giant pulses suggest that the spectra of the individual giant pulses do not actually follow a simple power law. The observed shapes of the giant pulses at all three frequencies are determined by scattering on interstellar plasma irregularities. The scatter broadening of the pulses and its frequency dependence were determined as tau_sc=20*(f/100)^(-3.5 +/- 0.1) ms, where the frequency f is in MHz.Comment: 13 pages, 1 figure, 1 table (originally published in Russian in Astronomicheskii Zhurnal, 2006, vol. 83, No. 7, pp. 630-637), translated by Georgii Rudnitski

DEVELOPMENT OF METHODICAL APPROACH TO AN ASSESSMENT OF INTERESTS OF STAKEHOLDER SMART SUPPLY CHAINS

Attention growth to management of chains of deliveries has caused search of new ways of improvement of logistic processes. At the same time the question of a role of the theory of stakeholders in formation and maintenance of chains of deliveries was staticized. The main attention of the concept of interested parties of rather logistic processes has concentrated on the main points of decision-making in a choice of routes for transportation of freights. In article the methodical approach developed by authors to the analysis of extent of influence of interests of stakeholders in management of chains of deliveries within digital transformation of logistics is considered. For a choice of optimum option of transportation of the freights, most realizing the transport capacity of Russia, authors have taken as a basis A. Garrison's fundamental approach, allowing to develop methodical approach to an assessment of interests of stakeholders of the international logistic knot of the country. The circle of the stakeholders (interested parties) involved in process of decision-making on a choice of an optimum route at implementation of transportation of freights is created. The main transnational corridors of transportation of goods from the People's Republic of China in the European Union and criteria by which it is possible to carry out their assessment for a choice of the most acceptable are defined. Methodical approach to an assessment of degree of compliance of routes to certain criteria according to interests of stakeholders is developed. Comparison of criteria among themselves, and also an assessment of their influence in each option of transportation have shown as far as interests of stakeholders of chains of deliveries differ. The hierarchy of the importance of each criterion for the described routes of transportation taking into account interests of stakeholders of chains of deliveries is created. The conclusion is drawn that the main factor in transportation of goods when using capacities of Russia is time. This criterion plays a significant role at a route choice, however at the high cost and insufficient reliability such route will concede in most cases to competitors. Proceeding from it, attraction of opportunities and advantages which can provide other options, becomes quite expedient. Thus, harmonization of the relations of stakeholders is reduced uniting their interests of rather allocated options of transportations on development of Russia as the international logistic knot and to show, what economic benefits they can receive from this interaction

Catalytic photometric determination of nitrate in nature water using stepwise injection analysis

Разработана кинетическая фотометрическая методика экспрессного определения нитрат-ионов в природных пресных и соленых водах с использованием циклического инжекционного анализа. Методика основана на каталитическом влиянии нитрит-ионов на реакцию окисления этилендиаминтетраацетата марганца (II) пероксидом водорода после предварительного восстановления нитрат-ионов до нитрит-ионов при помощи омедненного Cd-редуктора. В результате реакции образуется окрашенное соединение - этилендиаминтетраацетат марганца (III). Измерение оптической плотности раствора проводили при длине волны 520 нм. Диапазон определяемых концентраций 0.1-5 мг/л. Предел обнаружения 0.02 мг/л. Относительная случайная погрешность определения не превышает 15 %. Рассмотрены преимущества и недостатки расположения омедненного Cd-редуктора в гидравлических схемах проточно-инжекционного и циклического инжекционного анализов. Рассмотрен представленный в литературе вариант расположения омедненного Cd-редуктора в методике, реализованной в циклическом инжекционном анализе, и предложен альтернативный вариант размещения. Проведена проверка методики определения нитрат-ионов в пресной и соленой воде методом добавок и референтным методом. Основными преимуществами данной методики являются избирательность, экономия используемых реактивов и автоматически настраиваемая частота проведения анализов. Методика может быть использована для автоматического определения нитрат-ионов в природной воде в непрерывном режиме с максимальной производительностью 12 анализов/ч, а также в режиме с меньшей производительностью, с установленным перерывом между анализами.A new express technique for the kinetic catalytic photometric determination of nitrate by stepwise injection analysis is introduced. The detection is based on the catalytic effect of nitrite on the oxidation of ethylendiaminetetreaacetat manganese (II) to red ethylendiaminetetreaacetat manganese (III) by hydrogen peroxide. Nitrate was preliminary reduced to nitrite using copperised cadmium reductor column. The measurement of the red color absorbance was monitored at 520 nm wavelength. Determined the reliable working concentration range to be 0.1 - 5 mg/d

Detection of decametre-wavelength pulsed radio emission of 40 known pulsars

International audienceThe study of pulsars at the lowest radio frequencies observable from the ground (10-30 MHz) is complicated by strong interstellar (dispersion, scattering) and ionospheric (scintillation, refraction) propagation effects, as well as intense Galactic background noise and interference. However, it permits us to measure interstellar plasma parameters (the effects of which increase by a power of two to >4 times the wavelength), the spectrum and the pulse profile at low frequencies more accurately. Up to now, only ˜10 pulsars have been successfully detected at these frequencies. The recent upgrade of the receivers at the Ukrainian T-shaped Radio telescope, second modification (UTR-2) has increased its sensitivity and motivated a new search for pulsed radio emissions. In this work we carried out a survey of known pulsars with declination above -10°, period >0.1 s and dispersion measure (DM) < 30 pc cm-3, i.e. a sample of 74 sources. Our goal was either to detect pulsars not recorded before in the decametre range or to identify factors that prevent their detection. As a result, we have detected the radio emission of 40 pulsars, i.e. 55 per cent of the observed sample. For 30 of them, this was a first detection at these frequencies. Parameters of their average profiles have been calculated, including the intrinsic widening of the pulse (not due to interstellar scattering) with decreasing frequency. Furthermore, two pulsars beyond the selected DM (B0138+59 with DM ≈ 35 pc cm-3 and B0525+21 with DM ≈51 pc cm-3) were also detected. Our results indicate that there is still room to detect new transient and pulsed sources with low-frequency observations

Biochemical Content of Cambium of Abies nephrolepis

The peculiarity of bears behavior of stripping of bark is typical for all species. We have described the damage to trees, by Asiatic black bear (Ursus thibetanus) and brown bear (U. arctos) in Primorsky Krai and by brown bears on the Sakhalin Island during 1998–2015. In this study, we studied the damaged bark of the tree only in cases where it was clear that part of the cambium was eaten by bears. Cambium of species Abies nephrolepis is the most preferred for bear consumption in Primorsky Krai. We distinguished very large seasonal fluctuations in the amount of its consumption. The greatest interest of bears in this kind of food is in the summer time. We have analyzed the composition of the cambium of A. nephrolepis. These results suggest that the important purpose of the use of this kind of food is to restore and maintain the normal functioning of the intestines

Identification of cement in atmospheric particulate matter using the hybrid method of laser diffraction analysis and Raman spectroscopy

Environmental science; Atmospheric science; Ecology; Environmental chemistry; Environmental pollution; Atmospheric particulate matter, Laser diffraction analysis, PM10, Raman spectroscop

Erratum to: Plasma and saliva miR-21 expression in colorectal cancer patients

Erratum to: J Appl Genetics DOI:10.1007/s13353-016-0379-9 The Acknowledgement section in the original version is missing. Given in the following is the complete acknowledgement statement. Acknowledgements Michael N. Romanov is supported by a grant of the Government of Russian Federation (Contract No. 14.W03.31.0013)

Digital receivers for low-frequency radio telescopes UTR-2, URAN, GURT

This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. Since 1998, digital receivers performing on-the-fly dynamic spectrum calculations or waveform data recording without data loss have been used at the UTR-2 radio telescope, the URAN VLBI system, and the GURT new generation radio telescope. Here we detail these receivers developed for operation in the strong interference environment that prevails in the decameter wavelength range. Data collected with these receivers allowed us to discover numerous radio astronomical objects and phenomena at low frequencies, a summary of which is also presented.Comment: 24 pages, 15 figure

Glycyrrhetinic acid and its derivatives as inhibitors of poly(ADP-ribose)polymerases 1 and 2, apurinic/apyrimidinic endonuclease 1 and DNA polymerase β

Aim. For strengthening the efficiency of monofunctional alkylating antineoplastic drugs it is important to lower the capacity of base excision repair (BER) system which corrects the majority of DNA damages caused by these reagents. The objective was to create inhibitors of the key BER enzymes (PARP1, PARP2, DNA polymerase β, and APE1) by the directed modification of glycyrrhetinic acid (GA). Methods. Amides of GA were produced from the GA acetate by formation of the corresponding acyl chloride, amidation with the appropriate amine and subsequent deacylation. Small library of 2-cyano substituted derivatives of GA methyl esters was obtained by the structural modification of GA framework and carboxylic acid group. The inhibitory capacity of the compounds was estimated by comparison of the enzyme activities in specific tests in the presence of compounds versus their absence. Results. None of tested compounds inhibits PARP1 significantly. Unmodified GA and its morpholinic derivative were shown to be weak inhibitors of PARP2. The derivatives of GA containing keto-group in 11 triterpene framework were shown to be moderate inhibitors of pol β. Compound 3, containing 12-oxo-9(11)-en moiety in the ring C, was shown to be a single inhibitor of APE1 among all compounds studied. Conclusions. The class of GA derivatives, selective pol β inhibitors, was found out. The selective inhibitor of APE1 and weak selective inhibitor of PARP2 were also revealed