Multiple inverse problem

The problem of providing the required level of quality of products and/or technological processes often becomes difficult due to the fact that there is no general theory for determining optimal sets of values of primary factors, i.e. output parameters of parts and units comprising an object as well as ensuring the equivalence of object parameters to the quality requirements. This is the main reason why the development of complex systems and objects of vital importance takes several years. To create this theory, one has to overcome a number of difficulties and solve the following tasks: creation of reliable and stable mathematical models that indicate the influence of primary factors on output parameters; determination of accurate solutions when mathematical models are poorly stipulated; and creation of a method of assigning nominal values and tolerances for primary factors with regard to economical, technological and other criteria. All of the above-listed tasks are equally important. The present work is an attempt to describe a solution for this problem. The mathematically formalized aspect of the problem of providing the required level of quality has been called the “multiple inverse problem”

Identification of Physical and Mechanical Properties of Compound by Solving Inverse Problems

The paper presents a method of identification of physical and mechanical characteristics of the compound (calculated and experimental test method parameters). The idea of the method is that the studied material is connected with other materials, the characteristics of which are well known and differ from the characteristics of the material. Desired physical and mechanical properties should be considered unknown in the proposed calculation model, and the values of the parameters of trial constructions that can be measured accurately with experimental methods in the process of product operation, as well as characteristics of test materials and geometric dimensions of proposed structures are suggested to be placed in the same model as input information

Multiple inverse problem

The problem of providing the required level of quality of products and/or technological processes often becomes difficult due to the fact that there is no general theory for determining optimal sets of values of primary factors, i.e. output parameters of parts and units comprising an object as well as ensuring the equivalence of object parameters to the quality requirements. This is the main reason why the development of complex systems and objects of vital importance takes several years. To create this theory, one has to overcome a number of difficulties and solve the following tasks: creation of reliable and stable mathematical models that indicate the influence of primary factors on output parameters; determination of accurate solutions when mathematical models are poorly stipulated; and creation of a method of assigning nominal values and tolerances for primary factors with regard to economical, technological and other criteria. All of the above-listed tasks are equally important. The present work is an attempt to describe a solution for this problem. The mathematically formalized aspect of the problem of providing the required level of quality has been called the “multiple inverse problem”

Methods for testing and optimizing composite ceramics-compound joints by solving inverse problems of mechanics

The paper demonstrates methods for testing and selecting composite ceramics-compounds by solving inverse problems of mechanics. A method for the identification of physical and mechanical characteristics of the compound is proposed. The idea of the method is that the studied material is connected with other materials, the characteristics of which are well known and differ from the characteristics of the material. Desired physical and mechanical properties should be considered unknown in the proposed calculation model. Values of the parameters can be measured accurately with experimental methods in the process of product operation. Characteristics of test materials and geometric dimensions of proposed structures are suggested. The solution of the problem of optimizing the tolerances of physical and mechanical characteristics of materials is proposed. In order to ensure the strength of the structure, the geometric dimensions of the composite construction ceramic resistor-compound are suggested

Technique for IoT cyberattacks detection based on the energy consumption analysis

Today Smart Home is a system for managing the basic life support processes of both small systems (commercial, office premises, apartments, cottages) and large automated complexes (commercial and industrial complexes). One of the important tasks to be solved by the concept of a modern Smart Home is the problem of preventing the malware spread and the usage of IoT infrastructure. One of the possible approaches for abnormal behavior of the IoT devices and IoT cyberattack detection is the monitoring of the energy consumption. Thus, an effective control and monitoring of heating, ventilation, air conditioning, more efficient use of traditional appliances and the introduction of energy-efficient equipment in the building are important to ensure and decision making in the terms of cybersecurity. In addition, improving the efficiency of energy management and monitoring is the approach to increasing effectiveness of the IoT cyberattack detection in the IoT infrastructure. The paper presents a technique for IoT attacks detection based on the IoT devices energy consumption analysis, which take into account the energy consumption related user's preference modes. With aim to improve the accuracy of IoT cyberattacks detection and localize the IoT malware on these IoT devices the IoT software opcodes sequences analysis is applied. The proposed approach allows detecting the performing of the IoT devices such attacks, for example, as DoS/DDoS with high efficiency, at a level of about 99.88% and localizing malicious IoT software on these devices with accuracy of about 99.66%

Выбор веб-сервиса для создания цифрового образовательного мероприятия

The analysis of features and usability of online services of four platforms Simpoll, Survio, Mentometer and Google Forms that can be taken into account by teachers when choosing them for creating an educational resource. The most significant differences between these services and the factors that contribute to the rapid content filling of online surveys for any educational activities, taking into account their features, are identified. The main features of each of the presented services are described. The paper presents the results of designing a digital event using an open survey form on the example of an ecological and mathematical interactive rapid test for students of all forms and types of education. The survey on the quality of the event showed a high 85% level of satisfaction and interest of respondents in this testing format.Проведен анализ особенностей и удобоприменимости онлайн-сервисов четырех платформ Simpoll, Survio, Mentimeter и Google Формы, которые могут быть приняты во внимание преподавателями при их выборе для создания образовательного ресурса. Определены наиболее существенные отличия этих сервисов и факторы, способствующие быстрому наполнению содержанием онлайн-опросов по любым образовательным мероприятиям с учетом их особенностей. Описываются основные возможности каждого из представленных сервисов. Представлены результаты проектирования цифрового мероприятия с использованием открытой формы опроса на примере эколого-математического интерактивного экспресс-теста для обучающихся всех форм и видов образования. Проведенный опрос о качестве мероприятия показал высокий 85%-ный уровень удовлетворенности и выражение заинтересованности респондентов в таком формате тестирования

Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects

Nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid, can have a dose-dependent nephrotoxic effect. The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects caused by this medicinal product.The aim of the study was to evaluate potential nephrotoxic effects following a single oral administration of 75 mg of acetylsalicylic acid, based on the analysis of the pharmacokinetic parameters.Materials and methods: the study involved 24 healthy volunteers who received 75 mg of acetylsalicylic acid (tablets) once orally. The measurement of the active metabolite of acetylsalicylic acid—salicylic acid—in blood plasma was performed by HPLC/MS using an Agilent 1200 liquid chromatography system coupled to an Agilent 6140 tandem mass spectrometer. Agilent Eclipse XDB-C18 column (4.6 mm×150 mm; 5.0 μm) was used for chromatographic separation. The test procedure used in the study was validated. The results obtained were used to calculate the pharmacokinetic parameters: Cmax (maximum concentration), Tmax (time to maximum concentration), T1/2 (half-life of the drug), AUC0-t (area under the pharmacokinetic curve from 0 to the last time point of the curve), AUC0-∞ (total area under the pharmacokinetic curve from 0 to ∞), MRT (mean residence time of the drug in the blood), Kel (elimination rate constant), Cl/F (total clearance), Vd/F (apparent volume of distribution). The Statistics (22.0.0.0) software was used for statistical processing of the results.Results: T1/2 of salicylic acid in blood plasma was determined to be 1.6 ± 0.5 h, Cmax was 4523.0 ± 725.0 ng/mL, and Tmax was 0.98 ± 0.4 h. AUC0–t was equal to 16183.0 ± 3823.0 ng×h/m, Vd/F was 12.0 ± 3.1 L/kg, and MRT was 2.9 ± 0.6 h.Conclusions: the analysis of the pharmacokinetic parameters demonstrated a high absorption rate, intensive distribution, and moderate elimination rate of salicylic acid (the main metabolite of acetylsalicylic acid), indicating a low risk of nephrotoxic effects associated with the studied dose of the drug

The Demoiselle crane (Anthropoides virgo) population genetic structure in Russia

The Demoiselle crane (Anthropoides virgo Linneaus, 1758) is a widespread crane species of Eurasia distributed in the steppe and semi-desert zones from southeast Ukraine eastward to Northern China. The Demoiselle crane uses two wintering grounds in Africa and India corresponding to the European and Asian breeding parts of the range subdivided into several spatially separated breeding flocks. The first estimates of the genetic diversity and differentiation have been obtained from five of them: 1) Azov & Black Sea, 2) Caspian, 3) Volga & Ural, 4) South Siberian and 5) Eastern Asian sampled across the total breeding range in Russia using data from 10 microsatellite loci and the 1 003-bp control region of mitochondrial DNA. In total, the Demoiselle crane demonstrates high level of observed (HO = 0.638 ± 0.032) and expected (HE = 0.657 ± 0.023) hete-rozygosity and haplotype diversity (h = 0.960). Genetic dif­ferentiation among populations has shown to be weak for both the microsatellite loci (Wright’s FST = 0.052 or AMOVA estimate 0.016) and mtDNA (FST = 0.040). No evidence of significant population structuring of the Demoiselle crane has been found using the STRUCTURE analysis of multilo­cus microsatellite genotypes and the NETWORK grouping of control region haplotypes. Despite the haplotype diversity was high, the nucleotide diversity of the species was low (0.0033 ± 0.0003). Negative but non-significant Tajima’s and Fu’s tests did not suggest the recent population expansion in the Demoiselle crane evolutionary history which contrasts to other cranes of the Palearctic (the Eurasian crane Grus grus, and the Hooded crane G. monacha). These data indicate more stable conditions for the Demoiselle crane breeding groups in the steppe zone in Pleistocene as compared to boreal and subarctic breeding grounds of other crane species

Значение редокс-статуса коэнзима Q10 как биомаркера окислительного стресса

The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled release of reactive oxygen species, which leads to oxidative stress and development of pathologies. The objective of the study was to determine the content of coenzyme Q10 and its redox status in the human body as a biomarker of oxidative stress in various pathologies. This was achieved by assessing and consolidating data on changes in concentrations of the oxidized, reduced ubiquinone forms and total ubiquinone in various pathologies. Total serum ubiquinone was reduced in patients with chronic heart failure (0.68 μmol/L) compared with the control group (0.97 μmol/L). The redox status, expressed as the [ubiquinol]/ [ubiquinone] concentration ratio, decreased in patients with coronary heart disease (0.49 ± 0.34), diabetes (0.26 ± 0.16) compared with the healthy subjects (1.23–1.41). A negative correlation with malonic dialdehyde was observed. The authors analysed the possibility of assessing the efficacy of statin therapy by plasma ubiquinone concentration in patients. Patients with hyperlipidemia who received statins showed a statistically significant reduction in ubiquinol concentration after taking the drug (from 0.81 to 0.46 μg/mL) and the [ubiquinone]/[total ubiquinone] ratio (from 11 to 10 %), which confirms the potential mechanism of statinassociated muscle injury development. Thus, coenzyme Q10 redox status, as well as the concentrations of oxidized, reduced and total ubiquinone can be effective biomarkers of oxidative stress in cardiovascular diseases, diabetes, as well as an important indicator in evaluating the efficacy of hyperlipidemia treatment.Рассмотрена роль убихинона как редокс-молекулы, функциями которой являются перенос электронов в дыхательной цепи митохондрии и регенерация эндогенных антиоксидантов. Изменение редокс-путей электронов вызывает неконтролируемую выработку активных форм кислорода, что приводит к окислительному стрессу и развитию патологий. Цель работы — выявление содержания коэнзима Q10 и значения его редокс-статуса в организме как биомаркера окислительного стресса при различных патологиях, для чего были оценены и обобщены данные о динамике концентраций окисленной, восстановленной формы и общего убихинона при различных патологиях. Содержание общего убихинона в сыворотке крови пациентов с хронической сердечной недостаточностью было снижено (0,68 мкмоль/л) по сравнению с контрольной группой (0,97 мкмоль/л). Редокс-статус, выраженный как отношение концентрации [убихинол]/[убихинон], снижался у пациентов с ишемической болезнью сердца (0,49 ± 0,34), диабетом (0,26 ± 0,16) по сравнению со здоровыми лицами (1,23–1,41). При этом наблюдалась отрицательная корреляция с малоновым диальдегидом. Проведен анализ возможности оценки эффективности статинотерапии по содержанию убихинона в плазме крови пациентов. У пациентов с гиперлипидемией, получавших статины, были достоверно снижены концентрация убихинола после приема препарата (с 0,81 до 0,46 мкг/мл) и соотношение [убихинон]/[общий убихинон] (с 11 до 10 %), что подтверждает потенциальный механизм возникновения статин-ассоциированных поражений мышц. Таким образом, редокс-статус коэнзима Q10, а также концентрация окисленного, восстановленного и общего убихинона могут быть эффективными биомаркерами окислительного стресса при сердечно-сосудистых заболеваниях, диабете, а также важным показателем при оценке эффективности лечения гиперлипидемии