Risk and protective factors for release in outpatients with schizophrenia

eposterWe aim to determine risk and protective factors influencing relapse incidence in outpatient with schizophrenia. A longitudinal, observational study was done with outpatients with schizophrenia (F20) or schizoaffective disorder (F25)(DMS-IV and ICD-10), without hospitalization during the previous 6 months. The patients were consecutively included into the study to received oral (O-A) or long-acting injectable (depot-A) antipsychotics. Clinical stage evolution, compliance, efficacy and safety assessments (including PANSS, CGI-SSI, hospitalization rates, and adverse events) were recorded before and after 6 and 12 months of treatment. Results: 60 outpatients (aged 34.5±8.9, male 73%), 75% schizophrenia and 25% schizoaffective disorder diagnosis, 68.3% fewer than 15 years of schizophrenia evolution, 76.7% fewer than 5 times previous hospitalizations were treated with O-A (41.7%) or depot-A (58.3%) antipsychotics for at least one year. Depot-A treated patients showed a significant higher compliance compared to O-A patients during the all following time, lower PANSS (total, positive and negative) scores and CGI-SSI score (p<0.01), and a delayed relapse incidence and re-hospitalization to more than 1 year in the 48% of patients (relapse % depot/% oral) after 6 months 22.9%/52.0%, and after 12 months 48.6%/4.0%. Conclusion: There were protective factors which delayed relapse incidence in schizophrenia: Use of sustained-release preparations, family support. There were risk factors for occurrence of relapse in schizophrenia: cocaine, heroin and alcohol consumption, absence of family support, greater severity of patients assessed through CGI-SI, male sex, age older than 25 years and long-term evolution of the disorder.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Análisis de compuestos perfluorados en suero sanguíneo mediante microextracción con disolventes supramoleculares y cromatografía líquida/espectrometría de masas con trampa iónica

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

Avatars and Cartoons reduce anxiety in pediatric inpatients

Avatars and Cartoons reduce anxiety in pediatric inpatients I Bellido1, MV Bellido2, A Gomez-Luque3. 1University of Malaga, Pharmacology and Clinical Therapeutics, Spain, 2Regional University Hospital, Malaga, Surgery Service, Spain, 3Virgen de la Victoria University Hospital, Malaga, Anaesthesia Service, Spain Background and aim: Pain induces fear, stress and anxiety in young children. Avatars and cartoons explaining analgesic and sedative drugs administration routes may reduce children’s anxiety in young children. We quantify the possible antianxiety effect of avatars and cartoons explaining analgesic and sedative drug’s administration routes to inpatients children. Methods: A prospective, aleatorized, controlled study (blinded for the analyser) in inpatients children (< 6 years old) was done. Clinical stage, diagnostic, surgery, anaesthesia and all treatment procedures were recorded. Anxiety (STAIC test) was recorded before and 5 h and 24 h after drugs administration. A 15 minutes movie with avatars and cartoons explaining how the analgesic and sedative drugs were going to be administered was use in 120 children (movie group) and was compared to other group that could not see the movie (control group n=120). Results: Children, N=240, aged 3-6 years, 4.5±1 years old, 55% male, treated in emergency 50%, surgery (31.3%) and intensities care unit (18.8%) were enrolled. The drugs routes administration were oral (25%), intramuscular (29.6%), intravenous (39.6%), inhalatory (3.8%), others (2.1%). Children saw part or the full movie an average of 5.2±2.1 times. At 24 h of follow-up anxiety was higher in control than in movie group (8.5±3 vs. 4.3±1.6, p<0.05, Student t test). Children of the control group wept, complained, and called their parents during more time than movie group. Conclusion: The use of avatars and cartoons to explain analgesics and sedative drugs routes administration to inpatients young children reduced children’s anxiety.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A small non‐coding rna modulates expression of pilus‐1 type in streptococcus pneumoniae

Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, and about 30% of the pneumococcal clinical isolates show type I pili‐like structures. These long protein-aceous polymers extending from the bacterial surface are encoded by pilus islet 1 and play major roles in adhesion and host colonization. Pili expression is bistable and is controlled by the transcriptional activator RlrA. In this work, we demonstrate that the previously identified small noncoding RNA srn135 also participates in pilus regulation. Our findings show that srn135 is generated upon processing of the 5′‐UTR region of rrgA messenger and its deletion prevents the synthesis of RrgA, the main pili adhesin. Moreover, overexpression of srn135 increases the expression of all pili genes and rises the percentage of piliated bacteria within a clonal population. This regulation is mediated by the stabilization of rlrA mRNA since higher levels of srn135 increase its half‐life to 165%. Our findings suggest that srn135 has a dual role in pilus expression acting both in cis‐ (on the RrgA levels) and in trans‐ (modulating the levels of RlrA) and contributes to the delicate balance between pili expressing and non‐expressing bacteria

Inequality in mortality in pre-industrial Southern Europe during an epidemic episode : socio-economic determinants (eighteenth - nineteenth centuries Spain)

The objective of this study is to gain more comprehensive knowledge about social inequality in mortality in pre-industrial periods. With this aim, we have reconstructed the life courses of the inhabitants of the town of Vera in south-east Spain for the period 1797-1812 in order to estimate the influence of socio-economic status on ordinary and extraordinary mortality, given that, during this period, the town suffered from several epidemic outbreaks of yellow fever. As a result of these outbreaks, around a quarter of the town's population died. The results obtained indicate social inequality in mortality at least from the end of the eighteenth century. Although the differences are higher in mortality caused by non-infectious diseases or ill-defined causes, the coefficients also show a certain social gradient in mortality derived from infectious diseases. However, with respect to this latter type of mortality, the place of residence - seems to have a greater influence on the chances of survival than socio-economic status

Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat

Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Deconstructing corporate environmental, social, and governance performance: Heterogeneous stakeholder preferences in the food industry

Environmental, social, and governance (ESG) performance assessment has emerged as a way to analyze corporate sustainability. However, the literature suggests that stakeholders are not satisfied with advisory firms' current assessment approaches since they do not consider stakeholders' sustainability preferences. Adopting the stakeholder perspective, this study proposes a new approach to assess ESG performance by developing a stakeholder-specific composite indicator that considers different stakeholder profiles. The proposed approach is empirically implemented to assess the ESG performance of European food firms, as the food industry plays an essential role in achieving the Sustainable Development Goals. The results provide evidence of differences in individual stakeholders' preferences regarding ESG assessment, even within the same stakeholder group (e.g., investors, consumers, or non-governmental organizations). However, the results reveal that almost all the stakeholders sampled showed individual firm rankings similar to generic rankings provided by advisory firms. In any case, this evidence suggests the need to reconsider how ESG composite indicators are constructed, underlining the value of enhanced transparency and communication with stakeholders to provide more valuable and reliable composite indicators

Development and Evaluation of a Python Telecare System Based on a Bluetooth Body Area Network

This paper presents a prototype of a telemonitoring system, based on a BAN (Body Area Network) that is integrated by a Bluetooth (BT) pulse oximeter, a GPS (Global Positioning System) unit, and a smartphone. The smartphone is the hardware platformfor running a Python software thatmanages the Bluetooth piconet formed by the sensors. Thus the smartphone forwards the data received from the Bluetooth devices, encoded into JSON (JavaScript Object Notation), to a central server. This server provides universal access to the information of the patient’s location and health status through a web application based on AJAX (Asynchronous JavaScript and XML) technology. Additionally, for the described prototype, the study presents some performance analyses about several topics that are of great interest for the applicability of the prototype: (i) the technique used to forward the patient’s location and health status, (ii) the power consumption of the smartphone (which is compared with the measurements of an equivalent software developed for Java Micro Edition platform), and (iii) the web browser compatibility of the web application developed for the control and monitoring of the patients.Ministerio de Educación y Ciencia TEC2009-13763-C02-0

Prototyping of a Remote Monitoring System for a medical Personal Area Network using Python

This paper presents a prototype developed in Python of a pervasive mobile health system aimed at monitoring a patient in indoor and outdoor environments continuously. The system is based on a Bluetooth PAN (Personal Area Network), worn by the patient, whose master node, a smartphone, collects information about patient's location and health status and detects emergency situations. These data are sent to a central server through Wi-Fi or GPRSIUMTS, which allows physicians to get access to patient data and configure the PAN sensors remotely using a conventional web browser.Ministerio de Educación y Ciencia TEC2006-12211- C02-01/TC