Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis

Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap. There is increasing recognition, however, of a group of acidotic patients who have a large anion gap that is not explained by either keto- or lactic acidosis nor, in most cases, is inappropriate fluid resuscitation or ingestion of exogenous agents the cause. Methods: Plasma ultrafiltrate from patients with diabetic ketoacidosis, lactic acidosis, acidosis of unknown cause, normal anion gap metabolic acidosis, or acidosis as a result of base loss were examined enzymatically for the presence of low molecular weight anions including citrate, isocitrate, α-ketoglutarate, succinate, malate and d-lactate. The results obtained from the study groups were compared with those obtained from control plasma from normal volunteers. Results: In five patients with lactic acidosis, a significant increase in isocitrate (0.71 ± 0.35 mEq l-1), α-ketoglutarate (0.55 ± 0.35 mEq l-1), malate (0.59 ± 0.27 mEq l-1), and d-lactate (0.40 ± 0.51 mEq l-1) was observed. In 13 patients with diabetic ketoacidosis, significant increases in isocitrate (0.42 ± 0.35 mEq l-1), α-ketoglutarate (0.41 ± 0.16 mEq l-1), malate (0.23 ± 0.18 mEq l-1) and d-lactate (0.16 ± 0.07 mEq l-1) were seen. Neither citrate nor succinate levels were increased. Similar findings were also observed in a further five patients with high anion gap acidosis of unknown origin with increases in isocitrate (0.95 ± 0.88 mEq l-1), α-ketoglutarate (0.65 ± 0.20 mEq l-1), succinate (0.34 ± 0.13 mEq l-1), malate (0.49 ± 0.19 mEq l-1) and d-lactate (0.18 ± 0.14 mEq l-1) being observed but not in citrate concentration. In five patients with a normal anion gap acidosis, no increases were observed except a modest rise in d-lactate (0.17 ± 0.14 mEq l-1). Conclusion: The levels of certain low molecular weight anions usually associated with intermediary metabolism were found to be significantly elevated in the plasma ultrafiltrate obtained from patients with metabolic acidosis. Our results suggest that these hitherto unmeasured anions may significantly contribute to the generation of the anion gap in patients with lactic acidosis and acidosis of unknown aetiology and may be underestimated in diabetic ketoacidosis. These anions are not significantly elevated in patients with normal anion gap acidosis

Halogen bonding enhances nonlinear optical response in poled supramolecular polymers

We demonstrate that halogen bonding strongly enhances the nonlinear optical response of poled supramolecular polymer systems. We compare three nonlinear optical chromophores with similar electronic structures but different bond-donating units, and show that both the type and the strength of the noncovalent interaction between the chromophores and the polymer matrix play their own distinctive roles in the optical nonlinearity of the systems

On the detectability of non-trivial topologies

We explore the main physical processes which potentially affect the topological signal in the Cosmic Microwave Background (CMB) for a range of toroidal universes. We consider specifically reionisation, the integrated Sachs-Wolfe (ISW) effect, the size of the causal horizon, topological defects and primordial gravitational waves. We use three estimators: the information content, the S/N statistic and the Bayesian evidence. While reionisation has nearly no effect on the estimators, we show that taking into account the ISW strongly decreases our ability to detect the topological signal. We also study the impact of varying the relevant cosmological parameters within the 2 sigma ranges allowed by present data. We find that only Omega_Lambda, which influences both ISW and the size of the causal horizon, significantly alters the detection for all three estimators considered here.Comment: 11 pages, 9 figure

An operator-theoretic approach to differential positivity

Differentially positive systems are systems whose linearization along trajectories is positive. Under mild assumptions, their solutions asymptotically converge to a one-dimensional attractor, which must be a limit cycle in the absence of fixed points in the limit set. In this paper, we investigate the general connections between the (geometric) properties of differentially positive systems and the (spectral) properties of the Koopman operator. In particular, we obtain converse results for differential positivity, showing for instance that any hyperbolic limit cycle is differentially positive in its basin of attraction. We also provide the construction of a contracting cone field.A. Mauroy holds a BELSPO Return Grant and F. Forni holds a FNRS fellowship. This paper presents research results of the Belgian Network DYSCO, funded by the Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy Office.This is the author accepted manuscript. The final version is available from IEEE via http://dx.doi.org/10.1109/CDC.2015.740332

Square-tiled cyclic covers

A cyclic cover of the complex projective line branched at four appropriate points has a natural structure of a square-tiled surface. We describe the combinatorics of such a square-tiled surface, the geometry of the corresponding Teichm\"uller curve, and compute the Lyapunov exponents of the determinant bundle over the Teichm\"uller curve with respect to the geodesic flow. This paper includes a new example (announced by G. Forni and C. Matheus in \cite{Forni:Matheus}) of a Teichm\"uller curve of a square-tiled cyclic cover in a stratum of Abelian differentials in genus four with a maximally degenerate Kontsevich--Zorich spectrum (the only known example found previously by Forni in genus three also corresponds to a square-tiled cyclic cover \cite{ForniSurvey}). We present several new examples of Teichm\"uller curves in strata of holomorphic and meromorphic quadratic differentials with maximally degenerate Kontsevich--Zorich spectrum. Presumably, these examples cover all possible Teichm\"uller curves with maximally degenerate spectrum. We prove that this is indeed the case within the class of square-tiled cyclic covers.Comment: 34 pages, 6 figures. Final version incorporating referees comments. In particular, a gap in the previous version was corrected. This file uses the journal's class file (jmd.cls), so that it is very similar to published versio

Dominance margins for feedback systems

The paper introduces notions of robustness margins geared towards the analysis and design of systems that switch and oscillate. While such phenomena are ubiquitous in nature and in engineering, a theory of robustness for behaviors away from equilibria is lacking. The proposed framework addresses this need in the framework of p-dominance theory, which aims at generalizing stability theory for the analysis of systems with low-dimensional attractors. Dominance margins are introduced as natural generalisations of stability margins in the context of p-dominance analysis. In analogy with stability margins, dominance margins are shown to admit simple interpretations in terms of familiar frequency domain tools and to provide quantitative measures of robustness for multistable and oscillatory behaviors in Lure systems. The theory is illustrated by means of an elementary mechanical example.The research leading to these results has received funding from the European Research Council under the Advanced ERC Grant Agreement Switchlet n. 670645