Pathways to sex addiction: Relationships with adverse childhood experience, attachment, narcissism, self-compassion and motivation in a gender-balanced sample

Research about sex addiction and its relationships with other constructs remains unexplored. We recruited a gender-balanced sample (53 men, 51 women) who responded to measures of sex addiction, adverse childhood experience, adult attachment, narcissism, self-compassion and motivation. Sex addiction was found to be statistically significantly associated with these constructs. Anxious attachment statistically significantly mediated the relationship between adverse childhood experience and sex addiction and the relationship between narcissism and sex addiction. Self-compassion did not statistically significantly moderate the relationship between anxious attachment and sex addiction. Therapeutic approaches targeting attachment and narcissism such as relation-based or mindfulness-based interventions are recommended.N/

Computational framework for interactive architecting of complex systems

Presented is a novel framework for interactive systems architecture definition at early design stages. It incorporates graph‐theoretic data structures, entity relationships, and algorithms that enable the systems architect to operate interactively and simultaneously in different domains. It explicitly captures the “zigzagging” of the functional reasoning process, including not only allocated, but also the derived functions. A prototype software tool, AirCADia Architect, was implemented, which allowed the framework to be demonstrated to and tried hands‐on by practicing aircraft systems architects. The tool enables architects to effectively express their ideas when interactively synthesizing new architectures, while still retaining control over the process. The proposed approach was especially acknowledged as the way forward for rationale capture

From Model Based Systems Engineering to Model Based System Realization: Role and Relevance of IVTV Plan

Part 1: Knowledge Discovery and SharingInternational audienceThe IVTV Plan (Integration, Verification, Transition and Validation of the system before its Qualification) is developed and validated during the design stage. It details all the activities, resources, requirements, means, etc. requested during the realization stage so it is the hyphen between these two crucial stages in system life cycle. It is today necessary to help companies to better transfer detailed design models towards realization for many reasons discussed in this paper. Mainly, IVTV plan remains difficult to be exploited. This article proposes a first step towards a Model-Based Realization Plan, that is, a meta-model that represents the links between models that comes from Model-Based System Engineering and information required in the IVTV plan

Surveillance et détection des événements inhabituels en toxicovigilance : revue des méthodes pertinentes.

International audienceBACKGROUND: Declared cases of exposures related to potential toxic agents are reported through a national database, the French Network of Poison Centers, and account on average for 200,000 cases per year, including 75,000 to 80,000 symptomatic cases. These data are currently used to investigate signals from local, national or international institutional partners (such as hospitals, local health authorities, and the Rapid Alert System for Food and Feed). Our objective is to complete this classical toxicovigilance activity through the automated detection of unexpected or unusual events in order to identify precociously signals representing potential threats for public health. To reach this objective, the inventory of surveillance and detection methods of unexpected events is necessary.METHODS: A literature review was conducted via Scopus(®) and Pubmed(®) databases, completed with grey literature and data available on worldwide vigilance systems' websites.RESULTS: The most commonly used methods are disproportional measures in the field of pharmacovigilance, some of which are subject to a routine detection at regular time intervals. Criteria of signal generation differ from one system to another, which have implemented data filtering strategies before or after analysis, in order to decrease the number of generated signals and improve their priority level. These signals are then transmitted to an experts committee for a clinical and epidemiological evaluation, and at times, for informing the patient's medical records. We also notice an interest in other approaches such as surveillance methods of temporal series or symbolic methods for associative rules extraction between one or more drugs and one or more adverse effects, with the possibility to include other types of variables, such a demographic data. The developments of probabilistic-based algorithms have also been recently developed, opening new opportunities.CONCLUSION: These surveillance and detection methods are of high interest for the automated detection of signals from the French toxicovigilance network. The initial step to developing these methods consists in studying the statistical quality of data and targeting the needs and expectations of the toxicovigilance network for what we want and what we can detect