Mechanisms of variability in a convective basin

Author Posting. © Sears Foundation for Marine Research, 2009. This article is posted here by permission of Sears Foundation for Marine Research for personal use, not for redistribution. The definitive version was published in Journal of Marine Research 67 (2009): 273-303, doi:10.1357/002224009789954757.An idealized model for a convective basin is used to investigate the mechanisms of variability of the formation and export of dense water. In this model, which consists of two isopycnic layers, dense water formation is induced by surface buoyancy loss in the interior, which is at rest. Newly formed dense water is transmitted to the surrounding boundary current through parameterized eddy fluxes. Variability in the formation and export of dense water is due to changes in the two main drivers: variations in the surface buoyancy fluxes and variations in the large-scale wind via a barotropic boundary current. Numerical integrations of the nonlinear model, with parameters and forcings corresponding to the Labrador Sea, show that the rate of dense water formation in the interior of the basin is strongly affected by changes in the buoyancy forcing, but not significantly affected by seasonal to interannual changes in the wind-driven barotropic boundary current. The basin tends to integrate the buoyancy forcing variability with a memory time scale set by eddies, which is decadal for the Labrador Sea. Variability in dense water export, on the contrary, is strongly affected by changes in the wind-driven barotropic boundary current but hardly affected by changes in buoyancy forcing. Indeed changes in the transport of dense water at the basin outflow are dominated by those at the basin inflow, which, in this model, are directly related to fluctuations in the wind-driven barotropic boundary current. These results, which are consistent with analytical solutions of the linear model, suggest that fluctuations in the surface buoyancy fluxes in the interior Labrador Sea have little impact on the interannual variability of the dense water transport by the Deep Western Boundary Current at the outflow of the Labrador Sea, which is dominated by fluctuations in the wind-driven North Atlantic subpolar gyre, but influence the formation and export of recently ventilated waters.Support for JD from the NOAA Office of Hydrologic Development through a scientific appointment administered by UCAR is gratefully acknowledged. Support for FS was provided by NSF grant OCE−0525929. Support for MAS was provided by NSF grant OCE−0423975

Robust Optimization for Smart Machining Systems: An Enabler for Agile Manufacturing

ABSTRACT This paper reports our efforts towards developing a mathematical and information framework for optimization of machining processes within a Smart Machining System (SMS). An SMS uses diverse integrated technologies that enable an enterprise to: (1) produce the first and every product correct; (2) improve the response of the production system to changes in demand (just in time); (3) realize rapid and agile manufacturing; and (4) provide data to the rest of the enterprise as needed. Optimization of machining processes is an important component of an SMS and contributes to realizing these capabilities. Based on a prototype, we demonstrate the concepts for robust optimization within an SMS and develop requirements and challenges for robust optimization in an SMS

Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature

International audienceBackground. There are few data on anakinra use after failure of conventional medications for crystal-induced peripheral arthritis and/or crowned dens syndrome among complex hospitalized patients. Methods. We retrospectively analyzed the outcome of six patients affected with subacute crystal-induced arthritis who had received anakinra in second or third line therapy, including three patients with crowned dens syndrome and three others with gouty arthritis. Patients' comorbidities, reasons for anakinra use and associated drugs, and outcomes were recorded. Results. All patients presented with elevated inflammatory syndrome, systemic symptoms with poly/oligoarthritis. Except for absolute contraindications, all patients were previously treated with full or decreased dose of NSAID, colchicine, and/or glucocorticoids, with unsatisfactory response. All three gouty patients exhibited complete responses in all acute involvements under anakinra within 3 to 5 days, including one of them who needed the reintroduction of colchicine treatment that was previously unsuccessful. Crowned dens syndrome patients, including two with pseudogout and one with subacute hydroxyapatite deposition disease, needed 9 to 11 days to achieve complete response. Tolerance to anakinra was good. Conclusion. In case series of complex hospitalized patients, anakinra showed good activity in crowned dens syndrome and associated crystal-induced peripheral arthritis, with longer treatment duration than in gouty arthritis

Assessing the role of EO in biodiversity monitoring: options for integrating in-situ observations with EO within the context of the EBONE concept

The European Biodiversity Observation Network (EBONE) is a European contribution on terrestrial monitoring to GEO BON, the Group on Earth Observations Biodiversity Observation Network. EBONE’s aims are to develop a system of biodiversity observation at regional, national and European levels by assessing existing approaches in terms of their validity and applicability starting in Europe, then expanding to regions in Africa. The objective of EBONE is to deliver: 1. A sound scientific basis for the production of statistical estimates of stock and change of key indicators; 2. The development of a system for estimating past changes and forecasting and testing policy options and management strategies for threatened ecosystems and species; 3. A proposal for a cost-effective biodiversity monitoring system. There is a consensus that Earth Observation (EO) has a role to play in monitoring biodiversity. With its capacity to observe detailed spatial patterns and variability across large areas at regular intervals, our instinct suggests that EO could deliver the type of spatial and temporal coverage that is beyond reach with in-situ efforts. Furthermore, when considering the emerging networks of in-situ observations, the prospect of enhancing the quality of the information whilst reducing cost through integration is compelling. This report gives a realistic assessment of the role of EO in biodiversity monitoring and the options for integrating in-situ observations with EO within the context of the EBONE concept (cfr. EBONE-ID1.4). The assessment is mainly based on a set of targeted pilot studies. Building on this assessment, the report then presents a series of recommendations on the best options for using EO in an effective, consistent and sustainable biodiversity monitoring scheme. The issues that we faced were many: 1. Integration can be interpreted in different ways. One possible interpretation is: the combined use of independent data sets to deliver a different but improved data set; another is: the use of one data set to complement another dataset. 2. The targeted improvement will vary with stakeholder group: some will seek for more efficiency, others for more reliable estimates (accuracy and/or precision); others for more detail in space and/or time or more of everything. 3. Integration requires a link between the datasets (EO and in-situ). The strength of the link between reflected electromagnetic radiation and the habitats and their biodiversity observed in-situ is function of many variables, for example: the spatial scale of the observations; timing of the observations; the adopted nomenclature for classification; the complexity of the landscape in terms of composition, spatial structure and the physical environment; the habitat and land cover types under consideration. 4. The type of the EO data available varies (function of e.g. budget, size and location of region, cloudiness, national and/or international investment in airborne campaigns or space technology) which determines its capability to deliver the required output. EO and in-situ could be combined in different ways, depending on the type of integration we wanted to achieve and the targeted improvement. We aimed for an improvement in accuracy (i.e. the reduction in error of our indicator estimate calculated for an environmental zone). Furthermore, EO would also provide the spatial patterns for correlated in-situ data. EBONE in its initial development, focused on three main indicators covering: (i) the extent and change of habitats of European interest in the context of a general habitat assessment; (ii) abundance and distribution of selected species (birds, butterflies and plants); and (iii) fragmentation of natural and semi-natural areas. For habitat extent, we decided that it did not matter how in-situ was integrated with EO as long as we could demonstrate that acceptable accuracies could be achieved and the precision could consistently be improved. The nomenclature used to map habitats in-situ was the General Habitat Classification. We considered the following options where the EO and in-situ play different roles: using in-situ samples to re-calibrate a habitat map independently derived from EO; improving the accuracy of in-situ sampled habitat statistics, by post-stratification with correlated EO data; and using in-situ samples to train the classification of EO data into habitat types where the EO data delivers full coverage or a larger number of samples. For some of the above cases we also considered the impact that the sampling strategy employed to deliver the samples would have on the accuracy and precision achieved. Restricted access to European wide species data prevented work on the indicator ‘abundance and distribution of species’. With respect to the indicator ‘fragmentation’, we investigated ways of delivering EO derived measures of habitat patterns that are meaningful to sampled in-situ observations

Applications of Nanoscale Materials in the Fields of Electrochemistry and Photoelectrochemistry

We have illustrated the important role played by the nanoscale materials in three-up-to-date energy topics

On the role of eddies and surface forcing in the heat transport and overturning circulation in marginal seas

Author Posting. © American Meteorological Society, 2011. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 24 (2011): 4844–4858, doi:10.1175/2011JCLI4130.1.The factors that determine the heat transport and overturning circulation in marginal seas subject to wind forcing and heat loss to the atmosphere are explored using a combination of a high-resolution ocean circulation model and a simple conceptual model. The study is motivated by the exchange between the subpolar North Atlantic Ocean and the Nordic Seas, a region that is of central importance to the oceanic thermohaline circulation. It is shown that mesoscale eddies formed in the marginal sea play a major role in determining the mean meridional heat transport and meridional overturning circulation across the sill. The balance between the oceanic eddy heat flux and atmospheric cooling, as characterized by a nondimensional number, is shown to be the primary factor in determining the properties of the exchange. Results from a series of eddy-resolving primitive equation model calculations for the meridional heat transport, overturning circulation, density of convective waters, and density of exported waters compare well with predictions from the conceptual model over a wide range of parameter space. Scaling and model results indicate that wind effects are small and the mean exchange is primarily buoyancy forced. These results imply that one must accurately resolve or parameterize eddy fluxes in order to properly represent the mean exchange between the North Atlantic and the Nordic Seas, and thus between the Nordic Seas and the atmosphere, in climate models.This study was supported by the National Science Foundation under Grants OCE-0726339 and OCE-0850416

Tomato protoplast DNA transformation: physical linkage and recombination of exogenous DNA sequences

Tomato protoplasts have been transformed with plasmid DNA's, containing a chimeric kanamycin resistance gene and putative tomato origins of replication. A calcium phosphate-DNA mediated transformation procedure was employed in combination with either polyethylene glycol or polyvinyl alcohol. There were no indications that the tomato DNA inserts conferred autonomous replication on the plasmids. Instead, Southern blot hybridization analysis of seven kanamycin resistant calli revealed the presence of at least one kanamycin resistance locus per transformant integrated in the tomato nuclear DNA. Generally one to three truncated plasmid copies were found integrated into the tomato nuclear DNA, often physically linked to each other. For one transformant we have been able to use the bacterial ampicillin resistance marker of the vector plasmid pUC9 to 'rescue' a recombinant plasmid from the tomato genome. Analysis of the foreign sequences included in the rescued plasmid showed that integration had occurred in a non-repetitive DNA region. Calf-thymus DNA, used as a carrier in transformation procedure, was found to be covalently linked to plasmid DNA sequences in the genomic DNA of one transformant. A model is presented describing the fate of exogenously added DNA during the transformation of a plant cell. The results are discussed in reference to the possibility of isolating DNA sequences responsible for autonomous replication in tomato.