Spontane durale arteriovenöse Fistel am Sinus cavernosus: Demaskierung nach endoskopischer Nasennebenhöhlen-Operation

Zusammenfassung: Spontane arteriovenöse Fisteln können sich über längere Zeit symptomlos entwickeln, bevor sie mit Strömungsgeräuschen, Visusminderung, Exophthalmos und konjunktivaler Injektion symptomatisch werden. Wir stellen den seltenen Fall einer okkulten parainfektiösen duralen arteriovenösen Fistel vor. Diese demaskierte sich postoperativ durch akute Verschlechterung der venösen Drainage, möglicherweise aufgrund der intraoperativen Lagerung, positiver Beatmungsdrucke und Stauung durch die Nasentamponad

Effect of a Novel Nonviral Gene Delivery of BMP-2 on Bone Healing

Background. Gene therapeutic drug delivery approaches have been introduced to improve the efficiency of growth factors at the site of interest. This study investigated the efficacy and safety of a new nonviral copolymer-protected gene vector (COPROG) for the stimulation of bone healing. Methods. In vitro, rat osteoblasts were transfected with COPROG + luciferase plasmid or COPROG + hBMP-2 plasmid. In vivo, rat tibial fractures were intramedullary stabilized with uncoated versus COPROG+hBMP-2-plasmid-coated titanium K-wires. The tibiae were prepared for biomechanical and histological analyses at days 28 and 42 and for transfection/safety study at days 2, 4, 7, 28, and 42. Results. In vitro results showed luciferase expression until day 21, and hBMP-2-protein was measured from day 2 – day 10. In vivo, the local application of hBMP-2-plasmid showed a significantly higher maximum load after 42 days compared to that in the control. The histomorphometric analysis revealed a significantly less mineralized periosteal callus area in the BMP-2 group compared to the control at day 28. The rt-PCR showed no systemic biodistribution of luciferase RNA. Conclusion. A positive effect on fracture healing by nonviral BMP-2 plasmid application from COPROG-coated implants could be shown in this study; however, the effect of the vector may be improved with higher plasmid concentrations. Transfection showed no biodistribution to distant organs and was considered to be safe

Symmetry Analysis of Second Harmonic Generation at Surfaces of Antiferromagnets

Using group theory we classify the nonlinear magneto-optical response at low-index surfaces of fcc antiferromagnets, such as NiO. Structures consisting of one atomic layer are discussed in detail. We find that optical second harmonic generation is sensitive to surface antiferromagnetism in many cases. We discuss the influence of a second type of magnetic atoms, and also of a possible oxygen sublattice distortion on the output signal. Finally, our symmetry analysis yields the possibility of antiferromagnetic surface domain imaging even in the presence of magnetic unit-cell doubling.Comment: 23 pages, 10 figures incorporated. Accepted to Phys. Rev. B, scheduled for July'9

Nonlinear Magneto-Optics of Fe Monolayers from first principles: Structural dependence and spin-orbit coupling strength

We calculate the nonlinear magneto-optical response of free-standing fcc (001), (110) and (111) oriented Fe monolayers. The bandstructures are determined from first principles using a full-potential LAPW method with the additional implementation of spin-orbit coupling. The variation of the spin-orbit coupling strength and the nonlinear magneto-optical spectra upon layer orientation are investigated. We find characteristic differences which indicate an enhanced sensitivity of nonlinear magneto-optics to surface orientation and variation of the in-plane lattice constants. In particular the crossover from onedimensional stripe structures to twodimensional films of (111) layers exhibits a clean signature in the nonlinear Kerr-spectra and demonstrates the versatility of nonlinear magneto-optics as a tool for in situ thin-film analysis.Comment: 28 pages, RevTeX, psfig, submitted to PR

[Spontaneous dural arterio-venous fistula at the cavernous sinus: detected by decompensation following endoscopic sinus surgery]

Spontaneous dural arterio-venous fistulas can imperceptibly develop over a long time period before they suddenly develop symptoms like bruit, loss of vision, exophthalmos and conjunctival injection. We present the rare case of an occult, para-infectious, dural arterio-venous fistula which became symptomatic after endoscopic sinus surgery. Conjunctival injection and slight exophthalmos developed due to decompensation of venous drainage probably by intraoperative positioning of the patient, positive pressure ventilation and nasal packing

Management of Dehydration in Patients Suffering Swallowing Difficulties

Swallowing difficulties, also called dysphagia, can have various causes and may occur at many points in the swallowing process. The treatment and rehabilitation of dysphagia represent a major interdisciplinary and multiprofessional challenge. In dysphagic patients, dehydration is frequent and often accelerated as a result of limited fluid intake. This condition results from loss of water from the intracellular space, disturbing the normal levels of electrolytes and fluid interfering with metabolic processes and body functions. Dehydration is associated with increased morbidity and mortality rates. Dysphagic patients at risk of dehydration thus require close monitoring of their hydration state, and existing imbalances should be addressed quickly. This review gives an overview on dehydration, as well as its pathophysiology, risk factors, and clinical signs/symptoms in general. Available management strategies of dehydration are presented for oral, enteral, and parenteral fluid replacement

Fe(II) interaction with cement phases: Method development, wet chemical studies and X-ray absorption spectroscopy

10.1016/j.jcis.2020.11.085Journal of Colloid and Interface Science588692-70