Multilobular tumor of the zygomatic bone in a dog

Multilobular tumor of bone (MTB) (also known as Multilobular Osteochondrosarcoma) is an uncommon bone tumor frequently located on the skull of dogs, rarely on the ribs or pelvis. These neoplasms are slow growing, locally invasive, and have the potential to compress and invade the brain. A 10-year-old mixed breed dog was presented with a history of approximately 4 months of progressive growth of a left zygomatic mass. Radiographic investigation revealed a finely granular or stippled non homogeneous radiopaque mass involving the zygomatic arch. After surgery, grossly the neoplasm consisted of multiple, variably sized, grayish-white to yellow nodules separated by collagenous septa of different thickness. Histologically, the tumor was characterized by the presence of multiple lobules containing osteoid and cartilage, separated by a net of fibrous septae. This neoplastic pattern was consistent with a typical multilobular tumor of bone and based on clinical, radiographical, gross and light microscopic findings the definitive diagnosis was made. While reviewing veterinary literature only few cases of MTB were found in dogs

Breaking Barriers: Blood-brain barrier alterations in capillary cerebral amyloid angiopathy and Alzheimer's disease

Rozemuller, J.M. [Promotor]Vries, H.E. de [Promotor]Hoozemans, J.J.M. [Copromotor]Horssen, J. van [Copromotor

An associated partial skeleton of Jainosaurus cf. septentrionalis (Dinosauria: Sauropoda) from the Late Cretaceous of Chhota Simla, Central India

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86940/1/j.1475-4983.2011.01087.x.pd

A Measurement Tool for Circular Economy Practices: A Case Study in Pallet Supply Chains

A circular economy (CE) is an economic system where products and services are traded in closed loops or ‘cycles’. This work develops a framework for assessing the extent to which product supply chains incorporate circular economy principles, and applies this framework to a specific material handling application, the wooden pallet supply chain. The main decisions affecting circularity and the most common decision alternatives for the wooden pallet supply chain are identified for the Pre-manufacturing, manufacturing, product delivery, customer use, and end-of-life phases. A streamlined life cycle assessment tool is developed for supporting a quick analysis about how the level of adoption of CE strategies could support environmental sustainability in pallet supply chains. A questionnaire, scoring, and assessment are presented for each phase of a pallet supply chain to reduce input and use of natural resources, reduce emission levels, reduce valuable materials losses, increase share of renewable and recyclable resources, and increase the value of durability of products. A case study is used to test the proposed method and present a contrast between two scenarios

A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells.

Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs) are important modulators of gene expression, yet their role in endocrine cell differentiation has not been systematically explored. Here we characterize miRNA-regulatory networks active in human endocrine cell differentiation by combining small RNA sequencing, miRNA over-expression, and network modeling approaches. Our analysis identified Let-7g, Let-7a, miR-200a, miR-127, and miR-375 as endocrine-enriched miRNAs that drive endocrine cell differentiation-associated gene expression changes. These miRNAs are predicted to target different transcription factors, which converge on genes involved in cell cycle regulation. When expressed in human embryonic stem cell-derived pancreatic progenitors, these miRNAs induce cell cycle exit and promote endocrine cell differentiation. Our study delineates the role of miRNAs in human endocrine cell differentiation and identifies miRNAs that could facilitate endocrine cell reprogramming

Hydrodynamics and Nonlocal Conductivities in Vortex States of Type II Superconductors

A hydrodynamical description for vortex states in type II superconductors is presented based on the time-dependent Ginzburg-Landau equation (TDGL). In contrast to the familiar extension of a single vortex dynamics based on the force balance, our description is consistent with the known hydrodynamics of a rotating neutral superfluid and correctly includes informations on the Goldstone mode. Further it enables one to examine nonlocal conductivities perpendicular to the magnetic field in terms of Kubo formula. The nonlocal conductivities deviate from the usual vortex flow expressions typically when the nonlocality parallel to the field becomes weaker than the perpendicular one measuring a degree of positional correlations, and, for instance, the superconducting contribution of dc Hall conductivity nonlocal only in directions perpendicular to the field becomes vanishingly small in the situations with large shear viscosity, leading to an experimentally measurable relation $\rho_{xy} \sim {\rho_{xx}^2}$ among the total resistivity components. Other situations are also discussed on the basis of the resulting expressions.Comment: 12 pages, no figures, to appear in J. Phys. Soc. Jpn. in October, 199

Alu fossil relics - distribution and insertion polymorphism

Screening of a human genomic library with an oligonucleotide probe specific for one of the young subfamilies of Alu repeats (Ya5/8) resulted in the identification of several hundred positive clones. Thirty-three of these clones were analyzed in detail by DNA sequencing. Oligonucleotide primers complementary to the unique sequence regions flanking each Alu repeat were used in PCR-based assays to perform phylogenetic analyses, chromosomal localization, and insertion polymorphism analyses within different human population groups. All 33 Alu repeats were present only in humans and absent from orthologous positions in several nonhuman primate genomes. Seven Alu repeats were polymorphic for their presence/absence in three different human population groups, making them novel identical-by-descent markers for the analysis of human genetic diversity and evolution. Nucleotide sequence analysis of the polymorphic Alu repeats showed an extremely low nucleotide diversity compared with the subfamily consensus sequence with an average age of 1.63 million years old. The young Alu insertions do not appear to accumulate preferentially on any individual human chromosome