Longidorus brevis sp. n. (Nematoda : Longidoridae) from Senegal, West Africa

#Longidorus brevis sp. n. is described from the rhizosphere of #Guiera senegalensis, #Pennisetum pedicellatum, #Cordyla pinnata and #Blumea aurita in Senegal. It is a small longidorid, morphologically resembling #L. juveniloides, #L. juveniis, #L. reneyii and #L. laevicapitatus$. The new species can be distinguished from these species by combinations of the following characters : short, thick body (L = 1.71-2.13 mm and a = 54.2-69.9), short odontostyle (40-43 micrometers), lobed amphidial pouches, distance of guide ring from anterior end (23-25.5 micrometers) and an elongate conoid tail with a slightly digitated terminus (c' = 1.89-2.61). (Résumé d'auteur

Aboriginal and Torres Strait Islander health and wellbeing: implications for a CBT framework

Research Aims/Questions: It has been acknowledged that the mental health of Australian Aboriginal and Torres Strait Islander people has been 'bedeviled' by the inappropriate application of non-Indigenous models of mental health. Given the poor health outcomes of Indigenous people, another approach to mental health practice is required. In order to enhance Indigenous health and wellbeing it is necessary for non-Indigenous practitioners to find a culturally safe way in which to enter the negotiated space of cross-cultural mental health. This will be facilitated through understanding both the points of similarity and divergence in perspectives of mental health across cultures. The current study aimed to explore urban Aboriginal and Torres Strait Islander’s understandings of mental health using a positive psychology framework. Methodology: A qualitative research project was conducted with a sample of 19 Australian Aboriginal and Torres Strait Islanders people. Data was collected via individual semi-structured interviews and focus groups. Thematic analysis was conducted to identify themes within the data. Conclusion: Four themes emerged as reflecting health and wellbeing – coping skills, knowledge, social support, and connectedness. The theme of connectedness to country, family and kinship, cultural knowledge and social networks emerged as reflecting a unique contribution to Indigenous health and wellbeing. However, the themes of coping skills, knowledge and social support shared cross-cultural meaning. In particular, coping skills identified in the behavioural, emotional and cognitive domains shared many cross-culturally applicable avenues for intervention. Therapeutic interventions in these domains are already well established within cognitive behaviour therapies. It is the cross-cultural understandings within these themes that offer clinicians a culturally safe avenue for supporting Australian Aboriginal and Torres Strait Islander health and wellbeing

Comparaison de quelques peuplements nématologiques des Petites Antilles

L'enquête faunistique effectuée sur trois îles des Antilles : Union, Barbade et la Martinique a permis de collecter 63 espèces de nématodes appartenant à 25 genres. Plus de la moitié des genres sont multispécifiques, avec un maximum de 7 espèces pour le genre #Xiphinema. A l'exception de 4 espèces : #Tylenchorhynchus curvus Williams, 1960, #Gracilacus aonli (Misra & Edward, 1971) Raski, 1976, #Helicotylenchus retusus Siddiqi & Brown, 1964 et #Pratylenchus teres Khan & Singh, 1975, toutes les autres existent en Amérique du Sud. Trois espèces seulement sont communes aux trois îles : #Paratylenchus elachistus Steiner, 1949, #Pratylenchus zeae Graham, 1951 et #Rotylenchus reniformis Linford & Oliveira, 1940. C'est à la Martinique, la plus vaste des trois îles, où l'altitude est la plus élevée, la pluviométrie la plus forte, qu'il y a le plus d'espèces et de genres, bien que la plus éloignée du continent américain. Le taux d'endémisme qui atteint 7 % est relativement faible. (Résumé d'auteur

Palaeoceanographic implications of new and revised bio-chronostratigraphic constraints from the Profitis Ilias Unit (Rhodes, Greece)

Middle Oxfordian-early Kimmeridgian radiolaria, extracted from the top of radiolarites of Profitis Ilias unit (Rhodes island), suggest that the latter are essentially Middle Jurassic in age and the overlying siliceous shales Late Jurassic. The previously identified Calpionellid horizon at the top of Profitis Ilias siliceous marls is now regarded as early Valanginian in age. The above chronostratigraphic constraints allow tentative correlations to be made between Profitis Ilias and Pindos-Olonos sedimentary units. Finally, the palaeoceanographic significance of the studied series in Rhodes and potentially similar pelagic sequences in the Marmaris area of Turkey are discussed

LXR regulate cholesterol homeostasis in the proximal mouse epididymis.

Oxysterol nuclear receptors liver x receptors (LXRalpha and LXRbeta) regulate lipid homeostasis when cells have to face high amounts of cholesterol and/or fatty acids. Male mice invalidated for both lxr (LXR-/-) are infertile by 5 months of age, and become sterile by the age of 9 months. The epididymis was previously shown to be affected by the gene invalidation, a phenotype specifically located in the two proximal segments of this organ. We demonstrate here that cholesteryl esters are accumulated in a specific cell type of the epididymal epithelium, the apical cells, in these two first segments, in LXR-/- male mice. These accumulations are correlated to a decrease in the amount of a specific membrane cholesterol transporter, ATP-binding cassette A1 (ABCA1) in the caput epididymidis of LXR-/- mice. This decrease is due to a transcriptional down-regulation, and we further demonstrate that ABCA1, in the two first segments of the caput epididymidis, is located in the apical cells, and that its accumulation is lost in these cells for LXR-/- male mice as soon as 4 months of age. These data bring new elements in the cholesterol trafficking pathways in the epididymis, and will help a better understanding of the molecular mechanisms occurring in this organ in relation to the sperm cells maturation process

Evaluating research impact: The development of a research for impact tool

© 2016 Tsey, Lawson, Kinchin, Bainbridge, McCalman, Watkin, Cadet-James and Rossetto. Introduction: This paper examines the process of developing a Research for Impact Tool in the contexts of general fiscal constraint, increased competition for funding, perennial concerns about the over-researching of Aboriginal and Torres Strait Islander issues without demonstrable benefits as well as conceptual and methodological difficulties of evaluating research impact. The aim is to highlight the challenges and opportunities involved in evaluating research impact to serve as resource for potential users of the research for impact tool and others interested in assessing the impact of research. Materials and methods: A combination of literature reviews, workshops with researchers, and reflections by project team members and partners using participatory snowball techniques. Results: Assessing research impact is perceived to be difficult, akin to the so-called "wicked problem," but not impossible. Heuristic and collaborative approach to research that takes the expectations of research users, research participants and the funders of research offers a pragmatic solution to evaluating research impact. The logic of the proposed Research for Impact Tool is based on the understanding that the value of research is to create evidence and/or products to support smarter decisions so as to improve the human condition. Research is, therefore, of limited value unless the evidence created is used to make smarter decisions for the betterment of society. A practical way of approaching research impact is, therefore, to start with the decisions confronting decision makers whether they are government policymakers, industry, professional practitioners, or households and the extent to which the research supports them to make smarter policy and practice decisions and the knock-on consequences of doing so. Embedded at each step in the impact planning and tracking process is the need for appropriate mix of expertise, capacity enhancement, and collaborative participatory learning-by-doing approaches. Discussion: The tool was developed in the context of Aboriginal and Torres Strait Islander research but the basic idea that the way to assess research impact is to start upfront with the information needs of decisions makers is equally applicable to research in other settings, both applied (horizontal) and basic (vertical) research. The tool will be further tested and evaluated with researchers over the next 2 years (2016/17). The decision by the Australian Government to include 'industry engagement' and 'impact' as additions to the Excellence in Research for Australia (ERA) quality measures from 2018 makes the Research for Impact Tool a timely development. The wider challenge is to engage with major Australian research funding agencies to ensure consistent alignment and approaches across research users, communities, and funders in evaluating impact

Site effect estimation through site characterization from ambient noise recordings,

Site effect assessment is an important step in seismic risk mitigation. There is therefore a drastic need for co proxies to site effects estimates. In that context, a new promising approach was proposed, using the time-avera over the top z meters with z varying form 5, 10, 20 and 30 meters (Vsz) and the fundamental resonance frequen two-parameters characterization of a site. Then to assess site effect, a Site Amplification Prediction Equat completely defined by these two parameters was build-up based on Japanese data from the KiK-Net network. Thu to be validated using other dataset. For that aim the EUROSEIS-test data is a suitable one. The EUROSE sedimentary basin in northern-Greece that has been thoroughly investigated through grants from the European C mainly to study site effects. Fourteen accelerometric stations have been installed since 1995, that to date recorded 100 events. After a review of the main available information over the EUROSEIS-test, we end up with a poor Vs for some of the accelerometric stations. Thus eight accelerometric stations were selected for noise array me surveys to provide more details information about Vsz and f0 parameters. The noise array technique has been pro decades ago but its development is still in progress, particularly regarding the inversion step. Different approaches el al. 2009, Renalier et al. 2009) were tested in this study to provide Vsz. These two inversion strategies provide Vsz for z equals to 10, 20 and 30 meters. With the resulting Vsz and f0 from noise analysis, a validation-test of th SAPE was realized. The results of such a comparison are encouraging and indicate as well limitations of the SAP It is a promising tool for engineering and seismic risk management

Protein Block Expert (PBE): a web-based protein structure analysis server using a structural alphabet

Encoding protein 3D structures into 1D string using short structural prototypes or structural alphabets opens a new front for structure comparison and analysis. Using the well-documented 16 motifs of Protein Blocks (PBs) as structural alphabet, we have developed a methodology to compare protein structures that are encoded as sequences of PBs by aligning them using dynamic programming which uses a substitution matrix for PBs. This methodology is implemented in the applications available in Protein Block Expert (PBE) server. PBE addresses common issues in the field of protein structure analysis such as comparison of proteins structures and identification of protein structures in structural databanks that resemble a given structure. PBE-T provides facility to transform any PDB file into sequences of PBs. PBE-ALIGNc performs comparison of two protein structures based on the alignment of their corresponding PB sequences. PBE-ALIGNm is a facility for mining SCOP database for similar structures based on the alignment of PBs. Besides, PBE provides an interface to a database (PBE-SAdb) of preprocessed PB sequences from SCOP culled at 95% and of all-against-all pairwise PB alignments at family and superfamily levels. PBE server is freely available at

No one's discussing the elephant in the room: Contemplating questions of research impact and benefit in Aboriginal and Torres Strait Islander Australian health research

© 2015 Bainbridge et al. Background: There remains a concern that Indigenous Australians have been over-researched without corresponding improvements in their health; this trend is applicable to most Indigenous populations globally. This debate article has a dual purpose: 1) to open a frank conversation about the value of research to Indigenous Australian populations; and 2) to stimulate ways of thinking about potential resolutions to the lack of progress made in the Indigenous research benefit debate. Discussion: Capturing the meaning of research benefit takes the form of ethical value-oriented methodological considerations in the decision-making processes of Indigenous research endeavours. Because research practices come from Western knowledge bases, attaining such positions in research means reconciling both Indigenous and Western knowledge systems to produce new methodologies that guide planning, evaluating and monitoring of research practices as necessary. Increasingly, more sophisticated performance measures have been implemented to ensure academic impact and benefits are captured. Assessing societal and other non-academic impacts and benefits however, has not been accorded corresponding attention. Research reform has only focussed on research translation in more recent years. The research impact debate must take account of the various standards of accountability (to whom), impact priorities (for whom), positive and negative impacts, and biases that operate in describing impact and measuring benefit. Summary: A perennial question in Indigenous research discourse is whether the abundance of research conducted; purportedly to improve health, is justified and benefits Indigenous people in ways that are meaningful and valued by them. Different research stakeholders have different conceptions of the value and nature of research, its conduct, what it should achieve and the kinds of benefits expected. We need to work collaboratively and listen more closely to the voice of Indigenous Australians to better understand, demonstrate and measure health research benefits. The authors conclude that as an imperative, a systematic benefit assessment strategy that includes identification of research priorities and planning, monitoring and evaluation components needs to be developed and implemented across research projects. In Indigenous health research, this will often mean adopting a benefit-led approach by changing the way research is done and preferencing alternative research methodologies. As a point of departure to improving impact and reaching mutually beneficial outcomes for researchers and partners in Indigenous health research, we need to routinise the assessment of benefit from outset of research as one of the standards toward which we work

Chronic Methamphetamine Administration Causes Differential Regulation of Transcription Factors in the Rat Midbrain

Methamphetamine (METH) is an addictive and neurotoxic psychostimulant widely abused in the USA and throughout the world. When administered in large doses, METH can cause depletion of striatal dopamine terminals, with preservation of midbrain dopaminergic neurons. Because alterations in the expression of transcription factors that regulate the development of dopaminergic neurons might be involved in protecting these neurons after toxic insults, we tested the possibility that their expression might be affected by toxic doses of METH in the adult brain. Male Sprague-Dawley rats pretreated with saline or increasing doses of METH were challenged with toxic doses of the drug and euthanized two weeks later. Animals that received toxic METH challenges showed decreases in dopamine levels and reductions in tyrosine hydroxylase protein concentration in the striatum. METH pretreatment protected against loss of striatal dopamine and tyrosine hydroxylase. In contrast, METH challenges caused decreases in dopamine transporters in both saline- and METH-pretreated animals. Interestingly, METH challenges elicited increases in dopamine transporter mRNA levels in the midbrain in the presence but not in the absence of METH pretreatment. Moreover, toxic METH doses caused decreases in the expression of the dopamine developmental factors, Shh, Lmx1b, and Nurr1, but not in the levels of Otx2 and Pitx3, in saline-pretreated rats. METH pretreatment followed by METH challenges also decreased Nurr1 but increased Otx2 and Pitx3 expression in the midbrain. These findings suggest that, in adult animals, toxic doses of METH can differentially influence the expression of transcription factors involved in the developmental regulation of dopamine neurons. The combined increases in Otx2 and Pitx3 expression after METH preconditioning might represent, in part, some of the mechanisms that served to protect against METH-induced striatal dopamine depletion observed after METH preconditioning