445 research outputs found
Promoter hypermethylation of SHOX2 and SEPT9 is a potential biomarker for minimally invasive diagnosis in adenocarcinomas of the biliary tract
Clinicopathological data of the 20 biliary tract cancer cases and 100 gender- and age-matched controls included in plasma study. (XLSX 116 kb
Spatio-temporal distribution of nucleation events during crystal growth
We consider irreversible second-layer nucleation that occurs when two adatoms
on a terrace meet. We solve the problem analytically in one dimension for zero
and infinite step-edge barriers, and numerically for any value of the barriers
in one and two dimensions. For large barriers, the spatial distribution of
nucleation events strongly differs from , where is the
stationary adatom density in the presence of a constant flux. The probability
that nucleation occurs at time after the deposition of the second
adatom, decays for short time as a power law [] in and
logarithmically [] in ; for long time it decays
exponentially. Theories of the nucleation rate based on the assumption
that it is proportional to are shown to overestimate by a
factor proportional to the number of times an adatom diffusing on the terrace
visits an already visited lattice site.Comment: 4 pages, 3 figures; accepted for publication on PR
Interventions to improve executive functioning and working memory in school-aged children with AD(H)D:A randomised controlled trial and stepped-care approach
Improvement of the approaches to improve the health of the population in the regions of Russia
Significant differentiation of socio-economic indicators of the subjects of the Russian Federation indicates significant regional differences in the initial conditions of demographic development. The aim of the study is to develop measures to improve the policy in the field of public health at the regional level in Russia, taking into account the factors of formation of public health. We conducted a factor analysis of the socio-economic situation in the regions, followed by clustering on the basis of a list of selected statistical indicators, which allowed us to develop common approaches to improving health policy for each group of subjects of the Russian Federation, taking into account their main historical, geographical and socioeconomic characteristics
Simulations of energetic beam deposition: from picoseconds to seconds
We present a new method for simulating crystal growth by energetic beam
deposition. The method combines a Kinetic Monte-Carlo simulation for the
thermal surface diffusion with a small scale molecular dynamics simulation of
every single deposition event. We have implemented the method using the
effective medium theory as a model potential for the atomic interactions, and
present simulations for Ag/Ag(111) and Pt/Pt(111) for incoming energies up to
35 eV. The method is capable of following the growth of several monolayers at
realistic growth rates of 1 monolayer per second, correctly accounting for both
energy-induced atomic mobility and thermal surface diffusion. We find that the
energy influences island and step densities and can induce layer-by-layer
growth. We find an optimal energy for layer-by-layer growth (25 eV for Ag),
which correlates with where the net impact-induced downward interlayer
transport is at a maximum. A high step density is needed for energy induced
layer-by-layer growth, hence the effect dies away at increased temperatures,
where thermal surface diffusion reduces the step density. As part of the
development of the method, we present molecular dynamics simulations of single
atom-surface collisions on flat parts of the surface and near straight steps,
we identify microscopic mechanisms by which the energy influences the growth,
and we discuss the nature of the energy-induced atomic mobility
The process of irreversible nucleation in multilayer growth. I. Failure of the mean-field approach
The formation of stable dimers on top of terraces during epitaxial growth is
investigated in detail. In this paper we focus on mean-field theory, the
standard approach to study nucleation. Such theory is shown to be unsuitable
for the present problem, because it is equivalent to considering adatoms as
independent diffusing particles. This leads to an overestimate of the correct
nucleation rate by a factor N, which has a direct physical meaning: in average,
a visited lattice site is visited N times by a diffusing adatom. The dependence
of N on the size of the terrace and on the strength of step-edge barriers is
derived from well known results for random walks. The spatial distribution of
nucleation events is shown to be different from the mean-field prediction, for
the same physical reason. In the following paper we develop an exact treatment
of the problem.Comment: 19 pages, 3 figures. To appear in Phys. Rev.
Inorganic carbon promotes photosynthesis, growth, and maximum biomass of phytoplankton in eutrophic water bodies
1.The traditional perception in limnology has been that phytoplankton biomass in lakes is limited by phosphorus, nitrogen, and light, but not by dissolved inorganic carbon (DIC) because CO2 can be supplied from the atmosphere. We tested the possibility of carbon limitation of photosynthesis, growth, and biomass accumulation of phytoplankton communities across an alkalinity and DIC gradient (0.15–3.26 mM) in nutrient‐rich freshwater. 2.During 47‐day long experiments, we measured phytoplankton biomass, organic carbon, calcium, DIC, pH, and oxygen in indoor, constantly mixed mesocosms with either no removal or a 70% weekly removal of the biomass. Photosynthesis was measured in the morning and in the afternoon at high biomass. 3.Maximum biomass and organic carbon production increased two‐ to four‐fold with DIC, which supported 7% of organic carbon production at low DIC and 53% at high DIC concentration, while atmospheric CO2 uptake supplied the remainder. Weekly biomass removal increased growth rates through improved light conditions leading to enhanced total phytoplankton biomass production at high DIC. Photosynthesis was significantly higher in the morning compared to afternoon due to daily DIC depletion. 4.We conclude that phytoplankton photosynthesis, growth rate, maximum biomass, and organic carbon production can be markedly carbon limited in eutrophic lake waters. Consequently, lakes of high DIC and pH can support a faster primary production by greater DIC use and chemically enhanced atmospheric CO2 uptake.publishedVersio
The epidemiology of patellar luxation in dogs attending primary-care veterinary practices in England
A conscious mouse model of gastric ileus using clinically relevant endpoints
BACKGROUND: Gastric ileus is an unsolved clinical problem and current treatment is limited to supportive measures. Models of ileus using anesthetized animals, muscle strips or isolated smooth muscle cells do not adequately reproduce the clinical situation. Thus, previous studies using these techniques have not led to a clear understanding of the pathophysiology of ileus. The feasibility of using food intake and fecal output as simple, clinically relevant endpoints for monitoring ileus in a conscious mouse model was evaluated by assessing the severity and time course of various insults known to cause ileus. METHODS: Delayed food intake and fecal output associated with ileus was monitored after intraperitoneal injection of endotoxin, laparotomy with bowel manipulation, thermal injury or cerulein induced acute pancreatitis. The correlation of decreased food intake after endotoxin injection with gastric ileus was validated by measuring gastric emptying. The effect of endotoxin on general activity level and feeding behavior was also determined. Small bowel transit was measured using a phenol red marker. RESULTS: Each insult resulted in a transient and comparable decrease in food intake and fecal output consistent with the clinical picture of ileus. The endpoints were highly sensitive to small changes in low doses of endotoxin, the extent of bowel manipulation, and cerulein dose. The delay in food intake directly correlated with delayed gastric emptying. Changes in general activity and feeding behavior were insufficient to explain decreased food intake. Intestinal transit remained unchanged at the times measured. CONCLUSION: Food intake and fecal output are sensitive markers of gastric dysfunction in four experimental models of ileus. In the mouse, delayed gastric emptying appears to be the major cause of the anorexic effect associated with ileus. Gastric dysfunction is more important than small bowel dysfunction in this model. Recovery of stomach function appears to be simultaneous to colonic recovery
Which executive functioning deficits are associated with AD/HD, ODD/CD and comorbid AD/HD+ODD/CD?
Item does not contain fulltextThis study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3)~whether a combination of AD/HD and ODD/CD is associated with EF deficits (and the possibility that there is no association between EF deficits and AD/HD or ODD/CD in isolation). Subjects were 99~children ages 6–12 years. Three putative domains of EF were investigated using well-validated tests: verbal fluency, working memory, and planning. Independent of ODD/CD, AD/HD was associated with deficits in planning and working memory, but not in verbal fluency. Only teacher rated AD/HD, but not parent rated AD/HD, significantly contributed to the prediction of EF task performance. No EF deficits were associated with ODD/CD. The presence of comorbid AD/HD accounts for the EF deficits in children with comorbid AD/HD+ODD/CD. These results suggest that EF deficits are unique to AD/HD and support the model proposed by R. A. Barkley (1997).17 p
- …