1,080 research outputs found
Modelling the atmosphere of the carbon-rich Mira RU Vir
Context. We study the atmosphere of the carbon-rich Mira RU Vir using the
mid-infrared high spatial resolution interferometric observations from
VLTI/MIDI. Aims. The aim of this work is to analyse the atmosphere of the
carbon-rich Mira RU Vir, with state of the art models, in this way deepening
the knowledge of the dynamic processes at work in carbon-rich Miras. Methods.
We compare spectro-photometric and interferometric measurements of this
carbon-rich Mira AGB star, with the predictions of different kinds of modelling
approaches (hydrostatic model atmospheres plus MOD-More Of Dusty,
self-consistent dynamic model atmospheres). A geometric model fitting tool is
used for a first interpretation of the interferometric data. Results. The
results show that a joint use of different kind of observations (photometry,
spectroscopy, interferometry) is essential to shed light on the structure of
the atmosphere of a carbon-rich Mira. The dynamic model atmospheres fit well
the ISO spectrum in the wavelength range {\lambda} = [2.9, 25.0] {\mu}m.
Nevertheless, a discrepancy is noticeable both in the SED (visible), and in the
visibilities (shape and level). A possible explanation are intra-/inter-cycle
variations in the dynamic model atmospheres as well as in the observations. The
presence of a companion star and/or a disk or a decrease of mass loss within
the last few hundred years cannot be excluded but are considered unlikely.Comment: 15 pages. Accepted in A&
An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides to the optimal size. Genome Wide Association Studies highlighted non-synonymous polymorphisms in their coding regions as associated with several immune mediated diseases. The two genes lie contiguous and oppositely oriented on the 5q15 chromosomal region. Very little is known about the transcriptional regulation and the quantitative variations of these enzymes. Here, we correlated the level of transcripts and proteins of the two aminopeptidases in B-lymphoblastoid cell lines from 44 donors harbouring allelic variants in the intergenic region between ERAP1 and ERAP2. We found that the presence of a G instead of an A at SNP rs75862629 in the ERAP2 gene promoter strongly influences the expression of the two ERAPs with a down-modulation of ERAP2 coupled with a significant higher expression of ERAP1. We therefore show here for the first time a coordinated quantitative regulation of the two ERAP genes, which can be relevant for the setting of specific therapeutic approaches
New ATCA, ALMA and VISIR observations of the candidate LBV SK-67266 (S61): the nebular mass from modelling 3D density distributions
We present new observations of the nebula around the Magellanic candidate
Luminous Blue Variable S61. These comprise high-resolution data acquired with
the Australia Telescope Compact Array (ATCA), the Atacama Large
Millimetre/Submillimetre Array (ALMA), and VISIR at the Very Large Telescope
(VLT). The nebula was detected only in the radio, up to 17 GHz. The 17 GHz ATCA
map, with 0.8 arcsec resolution, allowed a morphological comparison with the
H Hubble Space Telescope image. The radio nebula resembles a spherical
shell, as in the optical. The spectral index map indicates that the radio
emission is due to free-free transitions in the ionised, optically thin gas,
but there are hints of inhomogeneities. We present our new public code RHOCUBE
to model 3D density distributions, and determine via Bayesian inference the
nebula's geometric parameters. We applied the code to model the electron
density distribution in the S61 nebula. We found that different distributions
fit the data, but all of them converge to the same ionised mass, ~0.1 , which is an order of magnitude smaller than previous estimates. We
show how the nebula models can be used to derive the mass-loss history with
high-temporal resolution. The nebula was probably formed through stellar winds,
rather than eruptions. From the ALMA and VISIR non-detections, plus the derived
extinction map, we deduce that the infrared emission observed by space
telescopes must arise from extended, diffuse dust within the ionised region.Comment: 17 pages, 9 figures. Authors list corrected. In press in MNRAS.
RHOCUBE code available online ( https://github.com/rnikutta/rhocube
Modeling and predicting the shape of the far-infrared to submillimeter emission in ultra-compact HII regions and cold clumps
Dust properties are very likely affected by the environment in which dust
grains evolve. For instance, some analyses of cold clumps (7 K- 17 K) indicate
that the aggregation process is favored in dense environments. However,
studying warm (30 K-40 K) dust emission at long wavelength (300
m) has been limited because it is difficult to combine far
infared-to-millimeter (FIR-to-mm) spectral coverage and high angular resolution
for observations of warm dust grains. Using Herschel data from 70 to 500
m, which are part of the Herschel infrared Galactic (Hi-GAL) survey
combined with 1.1 mm data from the Bolocam Galactic Plane Survey (BGPS), we
compared emission in two types of environments: ultra-compact HII (UCHII)
regions, and cold molecular clumps (denoted as cold clumps). With this
comparison we tested dust emission models in the FIR-to-mm domain that
reproduce emission in the diffuse medium, in these two environments (UCHII
regions and cold clumps). We also investigated their ability to predict the
dust emission in our Galaxy. We determined the emission spectra in twelve UCHII
regions and twelve cold clumps, and derived the dust temperature (T) using the
recent two-level system (TLS) model with three sets of parameters and the
so-called T- (temperature-dust emissvity index) phenomenological models,
with set to 1.5, 2 and 2.5. We tested the applicability of the TLS
model in warm regions for the first time. This analysis indicates distinct
trends in the dust emission between cold and warm environments that are visible
through changes in the dust emissivity index. However, with the use of standard
parameters, the TLS model is able to reproduce the spectral behavior observed
in cold and warm regions, from the change of the dust temperature alone,
whereas a T- model requires to be known.Comment: Accepted for publication in A&A. 19 pages, 8 figures, 7 table
Large-scale environments of binary AGB stars probed by Herschel. II: Two companions interacting with the wind of pi1 Gruis
Context. The Mass loss of Evolved StarS (MESS) sample observed with PACS on
board the Herschel Space Observatory revealed that several asymptotic giant
branch (AGB) stars are surrounded by an asymmetric circumstellar envelope (CSE)
whose morphology is most likely caused by the interaction with a stellar
companion. The evolution of AGB stars in binary systems plays a crucial role in
understanding the formation of asymmetries in planetary nebul{\ae} (PNe), but
at present, only a handful of cases are known where the interaction of a
companion with the stellar AGB wind is observed.
Aims. We probe the environment of the very evolved AGB star Gruis on
large and small scales to identify the triggers of the observed asymmetries.
Methods. Observations made with Herschel/PACS at 70 m and 160 m
picture the large-scale environment of Gru. The close surroundings of
the star are probed by interferometric observations from the VLTI/AMBER
archive. An analysis of the proper motion data of Hipparcos and Tycho-2
together with the Hipparcos Intermediate Astrometric Data help identify the
possible cause for the observed asymmetry.
Results. The Herschel/PACS images of Gru show an elliptical CSE whose
properties agree with those derived from a CO map published in the literature.
In addition, an arc east of the star is visible at a distance of
from the primary. This arc is most likely part of an
Archimedean spiral caused by an already known G0V companion that is orbiting
the primary at a projected distance of 460 au with a period of more than 6200
yr. However, the presence of the elliptical CSE, proper motion variations, and
geometric modelling of the VLTI/AMBER observations point towards a third
component in the system, with an orbital period shorter than 10 yr, orbiting
much closer to the primary than the G0V star.Comment: 13 pages, 11 figures, accepted for publication in Astronomy &
Astrophysic
The Luminous Blue Variable RMC127 as seen with ALMA and ATCA
We present ALMA and ATCA observations of the luminous blue variable \rmc. The
radio maps show for the first time the core of the nebula and evidence that the
nebula is strongly asymmetric with a Z-pattern shape. Hints of this morphology
are also visible in the archival \emph{HST} image, which overall
resembles the radio emission. The emission mechanism in the outer nebula is
optically thin free-free in the radio. At high frequencies, a component of
point-source emission appears at the position of the star, up to the ALMA
frequencies. The rising flux density distribution () of this object suggests thermal emission from the ionized
stellar wind and indicates a departure from spherical symmetry with
. We examine different scenarios to explain this excess
of thermal emission from the wind and show that this can arise from a bipolar
outflow, supporting the suggestion by other authors that the stellar wind of
\rmc is aspherical. We fit the data with two collimated ionized wind models and
we find that the mass-loss rate can be a factor of two or more smaller than in
the spherical case. We also fit the photometry obtained by IR space telescopes
and deduce that the mid- to far-IR emission must arise from extended, cool
() dust within the outer ionized nebula. Finally we discuss two
possible scenarios for the nebular morphology: the canonical single star
expanding shell geometry, and a precessing jet model assuming presence of a
companion star.Comment: Accepted for publication in ApJ (minor revision included
AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population
Background BehcEet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-Bâ51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes) identified as associated to BD because of their LD with HLA-Bâ51. In fact, the HLA-Bâ51 is inherited as part of extended HLA haplotypes which are well preserved in patients with BD. Sardinian population is highly differentiated from other Mediterranean populations because of a distinctive genetic structure with very highly preserved HLA haplotypes. Patients and methods In order to identify other genes of susceptibility to BD within the HLA region we investigated the distribution of human Allograft Inflammatory Factor-1 (AIF-1) gene variants among BD patients and healthy controls from Sardinia. Six (rs2736182; rs2259571; rs2269475; rs2857597; rs13195276; rs4711274) AIF-1 single nucleotide polymorphisms (SNPs) and related extended haplotypes have been investigated as well as their LD within the HLA region and with HLA-Bâ51. Overall, 64 BD patients, 43 HLA-Bâ51 positive healthy controls (HC) and 70 random HC were enrolled in the study. Results HLA-Bâ51 was the only allele with significantly higher frequency (pc = 0.0021) in BD patients (40.6%) than in HC (9.8%). The rs2259571TAIF-1 variant had a significantly reduced phenotypic, but not allelic frequency in BD patients (72.1%; pc = 0.014) compared to healthy population (91.3%). That was likely due to the LD between HLA-Bâ51 and rs2259571G(pc= 9E-5), even though the rs2259571Gdistribution did not significantly differ between BD patients and HC. Conclusion No significant difference in distribution of AIF-1 SNPs haplotypes was observed between BD patients and HC and between HLA-Bâ51 positive BD patients and HLA-Bâ51 positive HC. Taken together, these results suggest that AIF-1 gene is not associated with susceptibility to BD in Sardinia
Detection and characterization of a 500 ÎŒm dust emissivity excess in the Galactic plane using Herschel/Hi-GAL observations
Context. Past and recent observations have revealed unexpected variations in the far-infrared â millimeter (FIR-mm) dust emissivity in the interstellar medium. In the Herschel spectral range, those are often referred to as a 500 ÎŒm emission excess. Several dust emission models have been developed to interpret astrophysical data in the FIR-mm domain. However, these are commonly unable to fully reconcile theoretical predictions with observations. In contrast, the recently revised two level system (TLS) model, based on the disordered internal structure of amorphous dust grains, seems to provide a promising way of interpreting existing data.
Aims. The newly available Herschel infrared GALactic (Hi-GAL) data, which covers most of the inner Milky Way, offers a unique opportunity to investigate possible variations in the dust emission properties both with wavelength and environment. The goal of our analysis is to constrain the internal structure of the largest dust grains on Galactic scales, in the framework of the TLS model.
Methods. By combining the IRIS (Improved Reprocessing of the IRAS Survey) 100 ÎŒm with the Hi-GAL 160, 250, 350, and 500 ÎŒm data, we model the dust emission spectra in each pixel of the Hi-GAL maps, using both the TLS model and, for comparison, a single modified black-body fit. The effect of temperature mixing along the line of sight is investigated to test the robustness of our results.
Results. We find a slight decrease in the dust temperature with distance from the Galactic center, confirming previous results. We also report the detection of a significant 500 ÎŒm emissivity excess in the peripheral regions of the plane (35° < |l| < 70°) of about 13â15% of the emissivity, which can reach up to 20% in some HII regions. We present the spatial distributions of the best-fit values for the two main parameters of the TLS model, i.e. the charge correlation length, lc, used to characterize the disordered charge distribution (DCD) part of the model, and the amplitude A of the TLS processes with respect to the DCD effect. These distributions illustrate the variations in the dust properties with environment, in particular the plausible existence of an overall gradient with distance to the Galactic center. A comparison with previous findings in the solar neighborhood shows that the local value of the excess is less than expected from the Galactic gradient observed here
Platelet Count and Volume and Pharmacological Closure with Paracetamol of Ductus Arteriosus in Preterm Infants
Background: Low platelet count might promote resistance to pharmacological closure with indomethacin and ibuprofen of a hemodynamically significant patent ductus arteriosus (hsPDA). However, no studies have investigated if this occurs with paracetamol. Methods: We retrospectively assessed the correlation between platelet count, mean platelet volume (MPV), and plateletcrit (PCT), as well as the effectiveness of paracetamol in closing hsPDA in infants born at 23+0 â31+6 weeks of gestation who were treated with 15 mg/kg/6 h of i.v. paracetamol for 3 days. Results: We studied 79 infants: 37 (47%) Had closure after a course of paracetamol and 42 (53%) did not. Platelet count and PCT did not correlate with paracetamol success or failure in closing hsPDA, while MPV was lower at birth (10.7 ± 1.4 vs. 9.5 ± 1.1; p < 0.001) and prior to starting therapy (11.7 ± 1.9 vs. 11.0 ± 1.6; p = 0.079) in refractory infants. Regression analysis confirmed that the low MVP measured prior to starting the treatment increased the risk of hsPDA paracetamol closure failure (OR 1.664, 95% CI 1.153â2.401). Conclusions: The greater MPV correlated positively with the effectiveness of paracetamol in closing hsPDA, while platelet count and PCT did not influence closure rates. Additional studies are needed to confirm our results
- âŠ