The Grizzly, March 28, 2019

Alumni Award Winners Announced • Diversity Monologues: A Night of Sharing • Ursinus Honors Dr. Crigler\u27s Legacy • Changing Comic Books One Superhero at a Time • Tess Beck \u2720 Embracing Aussie • Ursinus Students Building Houses in South Carolina • Opinions: College Admissions Scandal is Shocking, but not Surprising; Backlash Against Rep. Omar Underlines Weakness in Democratic Leadership • The Off to an Historic Start Award: Dom Fiorentino • Women\u27s Lacrosse Travels to Nashville and Earns First Win of the Season • UC Baseball Picking up Steam as Season Gets Into Full Swinghttps://digitalcommons.ursinus.edu/grizzlynews/1616/thumbnail.jp

The Grizzly, May 9, 2019

Kingston Out, Varner in for Bear Bash • Ursinus Reacts to Symbol of Hatred • Q&A with President Blomberg • Ursinus Graduates First Wave of Education Studies Majors • Breakaway Student Productions\u27 One Act Festival Premieres Four Student-Written Plays • Ursinus Fulbright Scholar, Jason Bennett \u2719, to Research Theoretical High-Energy Physics at the University of Groningen in the Netherlands • Opinions: Swarthmore Scandal Speaks to Greater Issues with Fraternity Culture; The United States Should Shorten its Work Week • Athlete Spotlight: Running Back Sam Ragland \u2721 • The Thanks for a Fun Two Years Award: You, the Fans • Bears Win Conference Championshiphttps://digitalcommons.ursinus.edu/grizzlynews/1622/thumbnail.jp

The Grizzly, February 28, 2019

To Squat or to Cluster? That is the Question • HEP Professor Goes on a Revelatory Journey • SUN Event Concludes Black History Month • Ursinus Makes Impressive List • Eye-Opening Experiences in Limerick, Ireland • Religion Battles Science in Agnes of God • Opinions: U.S.\u27s Nuclear Intervention in Japan was Justified / was not Justified • The Did You Guys Seriously Forget How Good I Am? Award: Courtney Cortese • Men\u27s Hoops Eliminated in CC Semifinal; Williams Jr. Ends Career as CC Record-Holder • New Lax Coach, Mercadante, off to Impressive Starthttps://digitalcommons.ursinus.edu/grizzlynews/1614/thumbnail.jp

The Grizzly, March 7, 2019

Chair of History Department Featured in Forbes • David Perry Shines Spotlight on College Problems • Book Club Brings Students and Faculty Together • Ariana Brown Reads at Ursinus • Student Worker Profile: Wismer Workers • Senior Feature: Paul Cottam • Opinions: America Could use a Universal Basic Income; New Housing Process Could be a New Mess • The That was the Coolest Lax Goal I\u27ve Ever Seen Award: Bobby McClure • Athlete Spotlight: Peter DeSimone • UC Swim Teams Complete Outstanding Seasons; Women Win 6th Straight Championshiphttps://digitalcommons.ursinus.edu/grizzlynews/1615/thumbnail.jp

Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids

Reduced taste sensitivity to 6-n-propylthiouracil (PROP), a genetic trait regarded as a general index for oral chemosensory perception, has been associated with a calorie-rich food preference and lower circulating endocannabinoid levels in participants with normal weight (NW), which suggests an adaptive mechanism to maintain a lean phenotype. In this study, we assessed whether participants with obesity (OB) show different patterns of plasma endocannabinoids and lipid metabolism biomarkers from those of NW, with further categorization based on their PROP sensitivity. NW and OB were classified by their PROP taster status as non-tasters (NT), medium-tasters (MT) and supertasters (ST). The blood samples were analysed for plasma endocannabinoids, nonesterified fatty acids (NEFA) and retinol, which have been associated to metabolic syndrome. In OB, we found a higher BMI and lower circulating endocannabinoids in ST vs. OB NT. However, OB ST showed lower circulating NEFA and retinol levels, which suggested a more favourable lipid metabolism and body fat distribution than those of OB NT. We confirmed lower plasma endocannabinoid levels in NW NT than in NW ST. These data suggest that PROP taste sensitivity determines metabolic changes and ultimately body mass composition differently in OB and NW

The Grizzly, February 14, 2019

Drone Policy Brings Safer Skies • A Quick Word on Wellness • The New V.P.\u27s Agenda • Ashley Henderson Joins IIE • Job, Internship and Networking Fair • LGBTea Time: A Safe, Open, and Supportive Event • Opinions: Elitism of Davos is Repulsive and Out-of-Touch; Climate Denial is More Malicious Than Ignorant • Love and Basketball and Tennis • Men\u27s Lax Prepped for Start of Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1612/thumbnail.jp

IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids

Regulation of the expression of GPCR fatty acid receptor genes has been examined in human adipocytes differentiated in culture. TNFα and IL-1β induced a marked reduction in GPR120 expression, mRNA level falling 17-fold at 24h in adipocytes incubated with TNFα. In contrast, GPR84 mRNA was dramatically increased by these cytokines (>500-fold for IL-1β at 4h); GPR41 expression was also stimulated. Rosiglitazone did not affect GPR84 expression, but GPR120 and GPR41 expression increased. Dexamethasone, insulin, linoleic and docosahexaenoic acids, and TUG891 (GPR120 agonist) had little effect on GPR120 and GPR84 expression. TUG891 did not attenuate the pro-inflammatory actions of TNFα and IL-1β. Docosahexaenoic acid slightly countered the actions of IL-1β on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines. GPR120 and GP84 gene expression in human adipocytes is highly sensitive to pro-inflammatory mediators; the inflammation-induced inhibition of GPR120 expression may compromise the anti-inflammatory action of GPR120 agonists

IL-1β and TNFα inhibit GPR120 (<i>FFAR4</i>) and stimulate GPR84 (<i>EX33</i>) and GPR41 (<i>FFAR3</i>) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of <i>n</i>-3 fatty acids

<p>Regulation of the expression of GPCR fatty acid receptor genes has been examined in human adipocytes differentiated in culture. TNFα and IL-1β induced a marked reduction in <i>GPR120</i> expression, mRNA level falling 17-fold at 24 h in adipocytes incubated with TNFα. In contrast, GPR84 mRNA was dramatically increased by these cytokines (>500-fold for IL-1β at 4 h); <i>GPR41</i> expression was also stimulated. Rosiglitazone did not affect <i>GPR84</i> expression, but <i>GPR120</i> and <i>GPR41</i> expression increased. Dexamethasone, insulin, linoleic and docosahexaenoic acids (DHA), and TUG891 (GPR120 agonist) had little effect on <i>GPR120</i> and <i>GPR84</i> expression. TUG891 did not attenuate the pro-inflammatory actions of TNFα and IL-1β. DHA slightly countered the actions of IL-1β on <i>CCL2</i>, <i>IL6</i> and <i>ADIPOQ</i> expression, though not on secretion of these adipokines. <i>GPR120</i> and <i>GP84</i> gene expression in human adipocytes is highly sensitive to pro-inflammatory mediators; the inflammation-induced inhibition of <i>GPR120</i> expression may compromise the anti-inflammatory action of GPR120 agonists.</p