Astrophysical inputs on the SUSY dark matter annihilation detectability

If dark matter (DM), which is considered to constitute most of the mass of galaxies, is made of supersymmetric (SUSY) particles, the centers of galaxies should emit gamma-rays produced by their self-annihilation. We present accurate estimates of continuum gamma-ray fluxes due to neutralino annihilation in the central regions of the Milky Way. We use detailed models of our Galaxy, which satisfy available observational data, and include some important physical processes, which were previously neglected. Our models predict that spatially extended annihilation signal should be detected at high confidence levels by incoming experiments assuming that neutralinos make up most of the DM in the Universe and that they annihilate according to current SUSY models.Comment: 4 pages, submitted to Physical Review Letter

Identification of reference genes for RT-qPCR data normalisation in aging studies

Aging is associated with changes in gene expression levels that affect cellular functions and predispose to age-related diseases. The use of candidate genes whose expression remains stable during aging is required to correctly address the age-associated variations in expression levels. Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) has become a powerful approach for sensitive gene expression analysis. Reliable RT-qPCR assays rely on the normalisation of the results to stable reference genes. Taken these data together, here we evaluated the expression stability of eight frequently used reference genes in three aging models: oncogene-induced senescence (OIS), in vitro and in vivo aging. Using NormFinder and geNorm algorithms, we identified that the most stable reference gene pairs were PUM1 and TBP in OIS, GUSB and PUM1 for in vitro aging and GUSB and OAZ1 for in vivo aging. To validate these candidates, we used them to normalise the expression data of CDKN1A, APOD and TFRC genes, whose expression is known to be affected during OIS, in vitro and in vivo aging. This study demonstrates that accurate normalisation of RT-qPCR data is crucial in aging research and provides a specific subset of stable reference genes for future aging studies

Is DNA Damage Response Ready for Action Anywhere?

Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability

The commissioning of CMS sites: improving the site reliability

The computing system of the CMS experiment works using distributed resources from more than 60 computing centres worldwide. These centres, located in Europe, America and Asia are interconnected by the Worldwide LHC Computing Grid. The operation of the system requires a stable and reliable behaviour of the underlying infrastructure. CMS has established a procedure to extensively test all relevant aspects of a Grid site, such as the ability to efficiently use their network to transfer data, the functionality of all the site services relevant for CMS and the capability to sustain the various CMS computing workflows at the required scale. This contribution describes in detail the procedure to rate CMS sites depending on their performance, including the complete automation of the program, the description of monitoring tools, and its impact in improving the overall reliability of the Grid from the point of view of the CMS computing system

New allowed mSUGRA parameter space from variations of the trilinear scalar coupling A0

In minimal Supergravity (mSUGRA) models the lightest supersymmetric particle (assumed to be the lightest neutralino) provides an excellent cold dark matter (CDM) candidate. The supersymmetric parameter space is significantly reduced, if the limits on the CDM relic density, obtained from WMAP data, are used. Assuming a vanishing trilinear scalar coupling A0 and fixed values of tan(beta), these limits result in narrow lines of allowed regions in the m0-m1/2 plane, the so called WMAP strips. In this analysis the trilinear coupling A0 has been varied within +/-4 TeV. A fixed non vanishing A0 value leads to a shift of the WMAP strips in the m0-m1/2 plane.Comment: Typos corrected, Fig.1. updated, references adde

Two photon annihilation of Kaluza-Klein dark matter

We investigate the fermionic one-loop cross section for the two photon annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray line with energy equal to the KK dark matter particle mass. We find that the cross section is large enough that if a continuum signature is detected, the energy distribution of gamma-rays should end at the particle mass with a peak that is visible for an energy resolution of the detector at the percent level. This would give an unmistakable signature of a dark matter origin of the gamma-rays, and a unique determination of the dark matter particle mass, which in the case studied should be around 800 GeV. Unlike the situation for supersymmetric models where the two-gamma peak may or may not be visible depending on parameters, this feature seems to be quite robust in UED models, and should be similar in other models where annihilation into fermions is not helicity suppressed. The observability of the signal still depends on largely unknown astrophysical parameters related to the structure of the dark matter halo. If the dark matter near the galactic center is adiabatically contracted by the central star cluster, or if the dark matter halo has substructure surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio

Do the Unidentified EGRET Sources Trace Annihilating Dark Matter in the Local Group?

In a cold dark matter (CDM) framework of structure formation, the dark matter haloes around galaxies assemble through successive mergers with smaller haloes. This merging process is not completely efficient, and hundreds of surviving halo cores, or {\it subhaloes}, are expected to remain in orbit within the halo of a galaxy like the Milky Way. While the dozen visible satellites of the Milky Way may trace some of these subhaloes, the majority are currently undetected. A large number of high-velocity clouds (HVCs) of neutral hydrogen {\it are} observed around the Milky Way, and it is plausible that some of the HVCs may trace subhaloes undetected in the optical. Confirming the existence of concentrations of dark matter associated with even a few of the HVCs would represent a dramatic step forward in our attempts to understand the nature of dark matter. Supersymmetric (SUSY) extensions of the Standard Model of particle physics currently suggest neutralinos as a natural well-motivated candidate for the non-baryonic dark matter of the universe. If this is indeed the case, then it may be possible to detect dark matter indirectly as it annihilates into neutrinos, photons or positrons. In particular, the centres of subhaloes might show up as point sources in gamma-ray observations. In this work we consider the possibility that some of the unidentified EGRET $\gamma$-ray sources trace annihilating neutralino dark matter in the dark substructure of the Local Group. We compare the observed positions and fluxes of both the unidentified EGRET sources and the HVCs with the positions and fluxes predicted by a model of halo substructure, to determine to what extent any of these three populations could be associated.Comment: 12 Pages, 4 figures, to appear in a special issue of ApSS. Presented at "The Multiwavelength Approach to Unidentified Gamma-Ray Sources" (Hong Kong, June 1 - 4, 2004; Conference organizers: K.S. Cheng and G.E. Romero

Adiabatic compression and indirect detection of supersymmetric dark matter

Recent developments in the modelling of the dark matter distribution in our Galaxy point out the necessity to consider some physical processes to satisfy observational data. In particular, models with adiabatic compression, which include the effect of the baryonic gas in the halo, increase significantly the dark matter density in the central region of the Milky Way. On the other hand, the non-universality in scalar and gaugino sectors of supergravity models can also increase significantly the neutralino annihilation cross section. We show that the combination of both effects gives rise to a gamma-ray flux arising from the Galactic Center largely reachable by future experiments like GLAST. We also analyse in this framework the EGRET excess data above 1 GeV, as well as the recent data from CANGAROO and HESS. The analysis has been carried out imposing the most recent experimental constraints, such as the lower bound on the Higgs mass, the \bsg branching ratio, and the muon $g-2$. In addition, the recently improved upper bound on $B(B_s \to \mu^+ \mu^-)$ has also been taken into account. The astrophysical (WMAP) bounds on the dark matter density have also been imposed on the theoretical computation of the relic neutralino density through thermal production.Comment: 32 pages, 11 figures, final version to appear in JCA

First bounds on the very high energy gamma-ray emission from Arp 220

Using the Major Atmospheric Gamma Imaging Cherenkov Telescope (MAGIC), we have observed the nearest ultra-luminous infrared galaxy Arp 220 for about 15 hours. No significant signal was detected within the dedicated amount of observation time. The first upper limits to the very high energy $\gamma$-ray flux of Arp 220 are herein reported and compared with theoretical expectations.Comment: Accepted for publication in Ap

Extending the distributed computing infrastructure of the CMS experiment with HPC resources

Particle accelerators are an important tool to study the fundamental properties of elementary particles. Currently the highest energy accelerator is the LHC at CERN, in Geneva, Switzerland. Each of its four major detectors, such as the CMS detector, produces dozens of Petabytes of data per year to be analyzed by a large international collaboration. The processing is carried out on the Worldwide LHC Computing Grid, that spans over more than 170 compute centers around the world and is used by a number of particle physics experiments. Recently the LHC experiments were encouraged to make increasing use of HPC resources. While Grid resources are homogeneous with respect to the used Grid middleware, HPC installations can be very different in their setup. In order to integrate HPC resources into the highly automatized processing setups of the CMS experiment a number of challenges need to be addressed. For processing, access to primary data and metadata as well as access to the software is required. At Grid sites all this is achieved via a number of services that are provided by each center. However at HPC sites many of these capabilities cannot be easily provided and have to be enabled in the user space or enabled by other means. At HPC centers there are often restrictions regarding network access to remote services, which is again a severe limitation. The paper discusses a number of solutions and recent experiences by the CMS experiment to include HPC resources in processing campaigns