New perturbative solutions of the Kerr-Newman dilatonic black hole field equations

This work describes new perturbative solutions to the classical, four-dimensional Kerr--Newman dilaton black hole field equations. Our solutions do not require the black hole to be slowly rotating. The unperturbed solution is taken to be the ordinary Kerr solution, and the perturbation parameter is effectively the square of the charge-to-mass ratio $(Q/M)^2$ of the Kerr--Newman black hole. We have uncovered a new, exact conjugation (mirror) symmetry for the theory, which maps the small coupling sector to the strong coupling sector ($\phi \to -\phi$). We also calculate the gyromagnetic ratio of the black hole.Comment: Revtex, 27 page

Seismic topographic scattering in the context of GW detector site selection

In this paper, we present a calculation of seismic scattering from irregular surface topography in the Born approximation. Based on US-wide topographic data, we investigate topographic scattering at specific sites to demonstrate its impact on Newtonian-noise estimation and subtraction for future gravitational-wave detectors. We find that topographic scattering at a comparatively flat site in Oregon would not pose any problems, whereas scattering at a second site in Montana leads to significant broadening of wave amplitudes in wavenumber space that would make Newtonian-noise subtraction very challenging. Therefore, it is shown that topographic scattering should be included as criterion in the site-selection process of future low-frequency gravitational-wave detectors.Comment: 16 pages, 7 figure

Squeezed Light for the Interferometric Detection of High Frequency Gravitational Waves

The quantum noise of the light field is a fundamental noise source in interferometric gravitational wave detectors. Injected squeezed light is capable of reducing the quantum noise contribution to the detector noise floor to values that surpass the so-called Standard-Quantum-Limit (SQL). In particular, squeezed light is useful for the detection of gravitational waves at high frequencies where interferometers are typically shot-noise limited, although the SQL might not be beaten in this case. We theoretically analyze the quantum noise of the signal-recycled laser interferometric gravitational-wave detector GEO600 with additional input and output optics, namely frequency-dependent squeezing of the vacuum state of light entering the dark port and frequency-dependent homodyne detection. We focus on the frequency range between 1 kHz and 10 kHz, where, although signal recycled, the detector is still shot-noise limited. It is found that the GEO600 detector with present design parameters will benefit from frequency dependent squeezed light. Assuming a squeezing strength of -6 dB in quantum noise variance, the interferometer will become thermal noise limited up to 4 kHz without further reduction of bandwidth. At higher frequencies the linear noise spectral density of GEO600 will still be dominated by shot-noise and improved by a factor of 10^{6dB/20dB}~2 according to the squeezing strength assumed. The interferometer might reach a strain sensitivity of 6x10^{-23} above 1 kHz (tunable) with a bandwidth of around 350 Hz. We propose a scheme to implement the desired frequency dependent squeezing by introducing an additional optical component to GEO600s signal-recycling cavity.Comment: Presentation at AMALDI Conference 2003 in Pis

The role of pre-school quality in promoting resilience in the cognitive development of young children

The study reported here investigates the role of pre-school education as a protective factor in the development of children who are at risk due to environmental and individual factors. This investigation builds upon earlier research by examining different kinds of 'quality' in early education and tests the hypothesis that pre-schools of high quality can moderate the impacts of risks upon cognitive development. Cognitive development was measured in 2857 English pre-schoolers at 36 and 58 months of age, together with 22 individual risks to children's development, and assessments were made of the quality of their pre-school provision. Multilevel Structural Equation Modelling revealed that: the global quality of pre-school can moderate the effects of familial risk (such as poverty); the relationships between staff and children can moderate the effects of child level risk (such as low birth weight); and the specific quality of curricular provision can moderate the effects of both. Policy makers need to take quality into account in their efforts to promote resilience in young 'at risk' children through early childhood services

A Field-Based Assessing the Role of PCV-2 and Other Swine Viruses in Postweaning Multisystemic Wasting Syndrome

A case-control study was conducted to assess the association of major swine viral pathogens, including porcine circovirus type 2 (PCV2) with postweaning multisystemic wasting syndrome (PMWS). Cases were defined as individual pigs with a clinical history of progressive weight loss and respiratory signs and that were subsequently diagnosed with PMWS on the basis of characteristic histopathological lesions. Controls were pigs clinically unaffected and/or from herds in which PMWS had not been diagnosed and with no clinical signs compatible with PMWS. A total of 31 cases and 56 controls were identified from diagnostic submissions or farms within a 6-month period. Among viruses examined, PCV2 appeared to be the most strongly associated with PMWS (P\u3c.05). Risk for PWMS was much higher if animal was coinfected with porcine reproductive and respiratory syndrome virus (odd ratio =31.2). However, PCV2 was found in 62.5% of the control animals and was not detected in 2 of the 31 PMWS pigs. Furthermore, no significant genetic difference was observed among PCV2 isolates from PMWS and clinically normal pigs. The role of PCV2 in PMWS remains to be reassessed

Optical cavities as amplitude filters for squeezed fields

We explore the use of Fabry-P\'erot cavities as high-pass filters for squeezed light, and show that they can increase the sensitivity of interferometric gravitational-wave detectors without the need for long (kilometer scale) filter cavities. We derive the parameters for the filters, and analyze the performance of several possible cavity configurations in the context of a future gravitational-wave interferometer with squeezed light (vacuum) injected into the output port.Comment: 9 pages, 6 figure

Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids

The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145. Exposure of neurons to the neurotoxin ethylcholine aziridinium (AF64A) results in activation of caspase-3 and a dramatic loss of p21(Waf1/Cip1) preceding apoptosis in neurons. These effects of AF64A are reversed by pretreatment with corticosterone. Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase. Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis. We identify p21(Waf1/Cip1) as a novel antiapoptotic factor for postmitotic neurons and implicate p21(Waf1/Cip1) as the molecular target of neuroprotection by high-dose glucocorticoids