Interferometric studies of a piano soundboard

Electronic speckle pattern interferometry has been used to study the deflection shapes of a piano soundboard. A design for an interferometer that can image such an unstable object is introduced, and interferograms of a piano soundboard obtained using this interferometer are presented. Deflection shapes are analyzed and compared to a finite element model, and it is shown that the force the strings exert on the soundboard is important in determining the mode shapes and resonant frequencies. Measurements of resonance frequencies and driving point impedance made using the interferometer are also presented

A Simple and Inexpensive Optical Technique to Help Students Visualize Mode Shapes

An imaging technique is introduced that is suitable for visualizing the mode shapes of vibrating structures in an educational setting. The method produces images similar to those obtained using electronic speckle pattern interferometry (ESPI) but it can be implemented for less than 1=10 the cost of a commercial ESPI system, and the apparatus is simple enough that it can be constructed by undergraduate students. This technique allows for real-time visualization of the normal modes and detection shapes of harmonically vibrating structures, including those with shapes that make generating Chladni patterns with sand or powder impossible. The theory of operation and construction details are discussed

Imaging of vibrating objects using speckle subtraction

A simple method for imaging vibrational motion is proposed. The process consists of capturing two speckled images of a region illuminated by coherent radiation. One of the images is captured before the onset of motion and the other during motion. If the mean speckle intensity is below the threshold for detection or above the saturation intensity of the detector, subtracting the two images produces a high contrast image of the moving region. A theory is shown to agree well with experimental data

S-wave splitting in the offshore South Island, New Zealand : insights into plate-boundary deformation

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 16 (2015): 2829–2847, doi:10.1002/2015GC005882.Local and regional S-wave splitting in the offshore South Island of the New Zealand plate-boundary zone provides constraints on the spatial and depth extent of the anisotropic structure with an enhanced resolution relative to land-based and SKS studies. The combined analysis of offshore and land measurements using splitting tomography suggests plate-boundary shear dominates in the central and northern South Island. The width of this shear zone in the central South Island is about 200 km, but is complicated by stress-controlled anisotropy at shallow levels. In northern South Island, a broader (>200 km) zone of plate-boundary parallel anisotropy is associated with the transitional faulting between the Alpine fault and Hikurangi subduction and the Hikurangi subduction zone itself. These results suggest S-phases of deep events (∼90 km) in the central South Island are sensitive to plate-boundary derived NE-SW aligned anisotropic media in the upper-lithosphere, supporting a “thin viscous sheet” deformation model.United States National Ocean Bottom Seismograph Instrumentation Pool2016-02-2

Upper mantle seismic anisotropy at a strike-slip boundary: South Island, New Zealand

New shear wave splitting measurements made from stations onshore and offshore the South Island of New Zealand show a zone of anisotropy 100–200 km wide. Measurements in central South Island and up to approximately 100 km offshore from the west coast yield orientations of the fast quasi-shear wave nearly parallel to relative plate motion, with increased obliquity to this orientation observed farther from shore. On the eastern side of the island, fast orientations rotate counterclockwise to become nearly perpendicular to the orientation of relative plate motion approximately 200 km off the east coast. Uniform delay times between the fast and slow quasi-shear waves of nearly 2.0 s onshore continue to stations approximately 100 km off the west coast, after which they decrease to ~1 s at 200 km. Stations more than ~300 km from the west coast show little to no splitting. East coast stations have delay times around 1 s. Simple strain fields calculated from a thin viscous sheet model (representing distributed lithospheric deformation) with strain rates decreasing exponentially to both the northwest and southeast with e-folding dimensions of 25–35 km (approximately 75% of the deformation within a zone 100–140 km wide) match orientations and amounts of observed splitting. A model of deformation localized in the lithosphere and then spreading out in the asthenosphere also yields predictions consistent with observed splitting if, at depths of 100–130 km below the lithosphere, typical grain sizes are ~ 6–7 mm.New Zealand. Ministry of Research, Science, and TechnologyNational Science Foundation (U.S.). Continental Dynamics Program (Grant EAR-0409564)National Science Foundation (U.S.). Continental Dynamics Program (Grant EAR-0409609)National Science Foundation (U.S.). Continental Dynamics Program (Grant EAR-0409835

A model for transition of 5 '-nuclease domain of DNA polymerase I from inert to active modes

Bacteria contain DNA polymerase I (PolI), a single polypeptide chain consisting of similar to 930 residues, possessing DNA-dependent DNA polymerase, 3'-5' proofreading and 5'-3' exonuclease (also known as flap endonuclease) activities. PolI is particularly important in the processing of Okazaki fragments generated during lagging strand replication and must ultimately produce a double-stranded substrate with a nick suitable for DNA ligase to seal. PolI's activities must be highly coordinated both temporally and spatially otherwise uncontrolled 5'-nuclease activity could attack a nick and produce extended gaps leading to potentially lethal double-strand breaks. To investigate the mechanism of how PolI efficiently produces these nicks, we present theoretical studies on the dynamics of two possible scenarios or models. In one the flap DNA substrate can transit from the polymerase active site to the 5'-nuclease active site, with the relative position of the two active sites being kept fixed; while the other is that the 5'-nuclease domain can transit from the inactive mode, with the 5'-nuclease active site distant from the cleavage site on the DNA substrate, to the active mode, where the active site and substrate cleavage site are juxtaposed. The theoretical results based on the former scenario are inconsistent with the available experimental data that indicated that the majority of 5'-nucleolytic processing events are carried out by the same PolI molecule that has just extended the upstream primer terminus. By contrast, the theoretical results on the latter model, which is constructed based on available structural studies, are consistent with the experimental data. We thus conclude that the latter model rather than the former one is reasonable to describe the cooperation of the PolI's polymerase and 5'-3' exonuclease activities. Moreover, predicted results for the latter model are presented

Proposing new variables for the identification of strategic groups in franchising

The identification of strategic groups in the Spanish franchising area is the main aim of this study. The authors have added some new strategic variables (not used before) to the study and have classified franchisors between sectors and distribution strategy. The results reveal the existence of four perfectly differentiated strategic groups (types of franchisors). One of the major implications of this study is that the variables that build a strategic group vary depending on the respective sector the network operates in and its distribution strategy. This fact indicates that including sector and distribution strategy is absolutely necessary to achieve good classifications of franchisor type

A Chromatic Treatment of Linear Polarization in the Solar Corona at the 2023 Total Solar Eclipse

The broadband solar K-corona is linearly polarized due to Thomson scattering. Various strategies have been used to represent coronal polarization. Here, we present a new way to visualize the polarized corona, using observations from the 2023 April 20 total solar eclipse in Australia in support of the Citizen CATE 2024 project. We convert observations in the common four-polarizer orthogonal basis (0{\deg}, 45{\deg}, 90{\deg}, & 135{\deg}) to -60{\deg}, 0{\deg}, and +60{\deg} (MZP) polarization, which is homologous to R, G, B color channels. The unique image generated provides some sense of how humans might visualize polarization if we could perceive it in the same way we perceive color.Comment: 4 pages, 1 figure; accepted for publication in Research Notes of the American Astronomical Society (RNAAS

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease. Although both blockade of glutamate receptors and inhibition of microglial activation are the therapeutic candidates for these neurodegenerative diseases, glutamate receptor blockers also perturbed physiological and essential glutamate signals, and inhibitors of microglial activation suppressed both neurotoxic/neuroprotective roles of microglia and hardly affected disease progression. We previously demonstrated that activated microglia release a large amount of glutamate specifically through gap junction hemichannel. Hence, blockade of gap junction hemichannel may be potentially beneficial in treatment of neurodegenerative diseases.In this study, we generated a novel blood-brain barrier permeable gap junction hemichannel blocker based on glycyrrhetinic acid. We found that pharmacologic blockade of gap junction hemichannel inhibited excessive glutamate release from activated microglia in vitro and in vivo without producing notable toxicity. Blocking gap junction hemichannel significantly suppressed neuronal loss of the spinal cord and extended survival in transgenic mice carrying human superoxide dismutase 1 with G93A or G37R mutation as an amyotrophic lateral sclerosis mouse model. Moreover, blockade of gap junction hemichannel also significantly improved memory impairments without altering amyloid β deposition in double transgenic mice expressing human amyloid precursor protein with K595N and M596L mutations and presenilin 1 with A264E mutation as an Alzheimer's disease mouse model.Our results suggest that gap junction hemichannel blockers may represent a new therapeutic strategy to target neurotoxic microglia specifically and prevent microglia-mediated neuronal death in various neurodegenerative diseases